Sentences with phrase «cell interaction with»

Scientists at The Wistar Institute Melanoma Research Center have made huge strides in understanding the biology that underlies this disease, from basic genetics to the study of melanoma cell interaction with the microenvironment and new concepts that describe the stem cell - like abilities of melanoma to evade treatment.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

Delineating breast cancer cell interactions with engineered bone microenvironments.

Modulation of T cell and B cell interactions with vascular endothelial cells by antibodies, complement, and platelets

Not exact matches

«In everyday interactions with significant others, people often assume that momentary distractions by their cell phones are not a big deal,» another researcher involved in the study, Meredith David, said.

Birch and Cobb maintain that the ecological model is more adequate than the mechanical model for explaining DNA, the cell, other biological subject matter (as well as subatomic physics), because it holds that living things behave as they do only in interaction with other things which constitute their environment (LL 83) and because «the constituent elements of the structure at each level (of an organism) operate in patterns of interconnectedness which are not mechanical» (LL 83).

The next goal of the researchers is to examine interactions between perovskites and other molecules, for example water molecules that are known to interfere with the performance of solar cells.

Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interrelationship of DNA, RNA and protein synthesis and learning how these interactions are regulated.

These differences can affect the biological identity of nanoparticles and thus alter their interaction with the cells.

Interaction between the PD - 1 protein found on killer T cells and its binding partner PD - 1L is one hallmark of immune exhaustion, and interfering with this interaction a potential strategy to overcome it.

The researchers have also developed an analogous model that works for calcium interactions with phospholipids at the cell membrane.

The bacterium Neisseria gonorrhoeae controls mechanical interactions among cells with extensions called pili.

This suggests that «the python intestine may represent a valuable model for studying the interactions of metabolism with the regulation of cell division / death and WNT signaling relevant to cancer,» the researchers said.

Although blood cells serve multiple roles in the body and have complex interactions with other cellular materials, most synthetic blood products have aimed to just stick to the bare basics — shuttling oxygen from the lungs to different vital organs and then bringing carbon dioxide back to the lungs to be exhaled.

Dr. Del Maestro adds, «Yong and colleagues at the University of Calgary have begun to unravel the complex interaction of the microglia with the brain tumor cells, resulting not only in furthering our understanding, but providing a new concept and drug which can now be immediately assessed in clinical trials.»

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

They then used fluorescent antibodies that bind specifically to the protein to trace the virus's interactions with various kinds of cultured cells.

When they administered minocycline — a tetracycline antibiotic with anti-inflammatory properties commonly used to treat bacterial infections, acne and arthritis — many of the abnormalities in the astroglial cells were corrected and there were more healthy interactions between the astroglia and neurons compared to the control cells without the defect.

Weeraratna's team used an artificial skin reconstruct model to recreate the interactions of melanoma cells with either a young or aged tumor microenvironment.

Although biologists have known for decades that egg cells provide sperm with a little chemical encouragement to reel them in, the molecular nature of this interaction has remained elusive.

Image courtesy of iStockphoto / BakiBG SAN ANTONIO, Texas — So much of our information from — and interaction with — the world is now mediated by computers, cell phones and tablets that health experts have been practically running themselves ragged trying to find ways to use these conduits to help people make healthier choices.Great success stories have come out of parts of the developing world, where cell phones have been used to improve maternal and infant care and help people adhere to medication guidelines.

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

The teams are currently working on the fabrication of 3D structures from the blend suitable for implantation in patient joints with future studies focusing on understanding the peculiar interactions between the blend and stem cells towards refining the quality of regenerated cartilage.

But exactly how the immune system works remains, in many ways, a mystery, as there are numerous cell types whose functions and interactions with our immune systems have not been well understood.

Disruption of TBK1 interactions with either CEP170 or NuMA resulted in defects in mitosis and prevented cell division.

It indicates that the interaction with mitochondria is driven by Toxoplasma, rather than the host cell, and it is likely something the parasite does «to enable survival in some particular subset of hosts,» he says.

Interactions with other cells, through direct contact or via various dissolved factors, are especially important.

In addition to answering basic questions about how Zika invades cells, Linhardt's group also wants to come up with a way to block the interactions between the virus and placental sugars, protecting the fetus from harm.

They tested these drugs one at a time for lethal interaction with 112 different tumor - suppressor gene mutations in human cancer cells growing in the lab.

In 2013, the team found that nitric oxide is involved in cocaine - induced cell death through its interactions with GAPDH, an enzyme, but didn't learn how precisely the cells were dying.

«Right now,» Wells said,» we're hypothesizing that the mechanical interactions modeled by the Shenoy lab explain aspects of cancer and fibrosis, and we're developing the experimental systems to confirm it with real cells.»

By interaction with externally docking ligand molecules, external signals are transmitted into the cell.

This image represents synthetic lethal wiring of a cancer cell, with previously known interactions in red and newly discovered interactions in gray.

Cells can be transfected with selected genes with specific properties as a means of evaluating the mechanisms of interaction between cells and chemiCells can be transfected with selected genes with specific properties as a means of evaluating the mechanisms of interaction between cells and chemicells and chemicals.

With DNA evidence as solid as that used to convict criminals, researchers can trace the shared genetic lineage of life's different branches back to the very base of the tree, some 4 billion years ago, when the interaction between primordial bacteria and viruses culminated in the «mother cell,» the common ancestor of all life on Earth.

In another study published this week the group investigated influenza pH1N1 virus - host cell interaction in detail and found that certain host function could be temporally inhibited with small molecule MK2206 to block influenza infection in cell culture.

At the IMCB, headed by Professor Chris Tan, we were able to increase our productivity through closer collaborations and interactions with scientists studying apoptosis and cell regulation.

The research highlights the importance of studying the effects of drugs not only on the tumor cells in a culture plate, but also on the interaction of the tumor cells with their own microenvironment.

To address these questions, Dang, Altman, and Hsieh collaborated with Penn colleague, Aalim Weljie, PhD, research assistant professor of Pharmacology, using an osteosarcoma cancer cell line to study the interaction of MYC and metabolism in cancer cells.

On the right, the presence within EGFR of a residue able to form additional interactions with osimertinib (as for the L718Q mutant form) prevents its reaction with Cys797 allowing EGFR to work and cancer cells to survive.

The study, which reveals a common egg protein architecture that is involved in the interaction with sperm in both mollusc and mammal, is published in the scientific journal Cell.

Its presence influences the behaviour of nanoparticles in the body by altering their chemical properties, destination, and their interactions with other cells.

For example, the aquaporin protein - mediated flow of water across biological cell membranes is down to a balance between hydrophobic and hydrophilic interactions with channel surfaces.

With the aid of FACS - FRET, protein interactions in living cells can be characterized.

«Our findings indicate the existence of long - distance interactions between lung tumors and bones: lung tumors remotely activate osteoblasts, and those bone cells, in turn, shape immunity by supplying tumors with cancer - promoting neutrophils,» says Pittet, who is an associate professor of Radiology at Harvard Medical School.

«Since patients with many types of cancer have elevated levels of myeloisd cells in their blood, it's possible that other tumors could have a similar interaction with bone to increase myeloid cell production.»

«This allowed us to examine the interactions of the florescent integrase under the light microscope both in vitro in a single HIV virion as well as in a human cell infected with it.»

The vibrant videos produced with the new technology show the movement and interactions of proteins as cells remodel their structural supports or reorganize their membranes to take up molecules from outside the cell.

«It was crucial to find out that synthesis of the anti-inflammatory cytokine IL - 10 by the B lymphocytes through the interaction with the protein «nuclear factor of activated T cells» (NFATc1), a transcription factor, was reduced,» Matthias Goebeler puts the study's central result in a nutshell.

The formation, growth, and division of the earliest cells may have occurred in response to similar interactions with mineral particles and inputs of material and energy.