Sentences with phrase «cell invasion through»

Here we show that an abundant stromal cell population, cancer - associated fibroblasts (CAFs), promote cancer cell invasion through the BM.

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In preclinical experiments, the researchers disrupted AEG - 1 / Akt2 interaction through a process known as competitive binding and observed a reduction in GBM cell survival and invasion.

The ability of cancer cells to change position within body tissues through cell migration and invasion represents the biggest threat of cancer to human health.

Resistance to malaria through structural variation of red blood cell invasion receptors.

We also examined the invasive ability of these cells using Matrigel invasion chamber and found that miR - 7 was also able to block the invasion of CSCs through Matrigel (Fig. 4A, right).

Effects of miR -145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K / AKT pathways.

Inhibition of cell migration and invasion of enzalutamide - resistant prostate cancer cells was effected by niclosamide through its effects on the androgen receptor (AR)- STAT3 signaling axis [40].

Distinct c - Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Epithelial - mesenchymal transition (EMT) contributes to the progression of cancer through enhanced invasion and stem - like properties of cancer cells.

The penetration of cells through BM barriers, called «invasion», is an important process during normal tissue development and in cancer metastasis.

Multiple studies have shown that fascin, through its role in formation of cellular protrusions such as filopodia and invadopodia, enhances cancer cell migration and invasion in vitro.

The first step is to tunnel through the surrounding matrix, considered «a critical event in tumor cell invasion.»

«Tumor growth, invasion, and metastasis are multistep processes» that includes not just cell proliferation, but invasion through the surrounding tissue, and «migration through basement membranes» to reach the bloodstream before the tumor can establish «new proliferating colonies» of cancer cells.

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