Sentences with phrase «cell level based»

Rainbow nanobubbles offer the ability to target specific pathology at cell level based on their theranostic functions.

To this end, we are developing a new multi-scale live imaging approach to characterize nuclear organization dynamics at the single cell level based on the simultaneous characterization of both the local dynamics of RNA polymerases and transcription factors and the large scale behavior of chromatin.

Not exact matches

People who include dishes like carrot soup in their diets on a regular basis also enjoy reduced cholesterol levels, healthy teeth, and gums, wrinkle prevention, the slowing down of aging of the cells in your body, as well as a clean colon.

Based on these results, the researchers conclude that neuronal activity itself plays an important role in the synthesis and maintenance of the myelin sheath, and that myelinated nerve cells therefore require a minimal level of sound - evoked stimulation.

Women with high levels of FGF1 were less likely to respond to platinum - based drugs, but blocking the gene makes their cells lose their resistance (British Journal of Cancer, DOI: 10.1038 / bjc.2012.410).

Prostate cancer risk groups are assigned based on the prostate biopsy results, which include the Gleason score (GS)-- an indication of how aggressively the tumor cells may behave — and the prostate specific antigen (PSA) level in the patient's blood at the time of diagnosis.

Researchers for the past decade have focused on the T cell approach, based on studies showing that monkeys receiving such vaccines against simian immunodeficiency virus, related to HIV, lived longer or had lower viral levels than usual.

On the other hand, when they increased let - 7 levels, the cells switched to a fatty acid - based metabolism and became larger, stronger and structurally and functionally more mature.

They found that when they decreased let - 7 levels, the cells reverted to a glucose - based metabolism and became smaller, weaker and structurally and functionally less mature.

MIT researchers have developed a way to measure white blood cell levels by imaging the cells as they flow through capillaries at the base of the fingernail.

Wyrick and WSU colleagues Peng Mao, Michael Smerdon and Steven Roberts irradiated yeast cells and looked for patterns of damage at the level of individual base pairs, the DNA building blocks whose order serves as an organism's blueprint.

Meanwhile the technologies needed to understand the regulation of fat accumulation in fat cells and thus the biological basis of obesity — specifically, techniques to accurately measure fatty acids and hormone levels in the blood — were not invented until the late 1950s.

Solar cells based on cadmium and tellurium could move closer to theoretical levels of efficiency because of some sleuthing by researchers at the Department of Energy's Oak Ridge National Laboratory.

Researchers also monitored prostate cancer risk, based on prostate - specific antigen levels and a rectal exam, and stroke risk, based on red blood cell levels during the treatment year and for at least a year afterward.

Through the use of localization - based super-resolution microscopy, researchers are able to photoactivate, image and follow these genetically encoded fluorescent proteins, one at a time, to study what is happening inside a cell at the molecular level.

Sex - based distinctions at the level of the cell may not only influence cancer risk but also the effectiveness of treatments.»

Abnormal levels of the proteins may be useful biomarkers that could help us study early treatments to limit or reverse the damage to brain cells and even prevent the development of the full - blown disease,» said study author Edward Goetzl, MD, a Professor of Medicine with the University of California, San Francisco, a researcher at the National Institute on Aging, and a scientist of NanoSomiX, Inc., a California - based biotechnology company that provided a grant for method development for the study.

«The urine metabolites can indicate the underlying function of the kidney at a biochemical and intracellular level,» he said, «and are well - conserved compared to many cell - based and protein measurements.

These treatments, in addition to being inconvenient for patients, are unable to adjust blood glucose levels on a minute - to - minute basis, as beta cells do in a healthy individual.

The article describes a novel image - based screen to identify compounds that increase SMN protein levels in subcellular compartments of intact cells.

When the mTORC1 (for «mechanistic target of rapamycin complex 1») pathway operates properly, it senses the amount of nutrients, specifically amino acids, available and restricts cell growth based on that level.

Techniques broadly used are various systematic perturbations (e.g. CRISPRs, shRNAs), single cell sequencing, ChIP - seq, and affinity - based proteomics to measure at the global and draft level scales.

Additionally, our doctors are able to view tissue cells in the body at a microscopic level, using a technique called probe - based confocal laser endomicroscopy (pCLE).

In the present study, the researchers have developed a mass spectrometry - based method that is sensitive and reproducible in order to measure, at steady - state conditions, absolute protein copy numbers across human tissues and cell lines and compared these levels with the corresponding mRNA levels using transcriptomics.

The finding is based on studies of mice with altered levels of the growth factor PDGF in neural stem cells, which play a key role in the development of the eye.

Oligonucleotide - labeled antibodies allow integration of cellular protein and transcriptome measurements at a single - cell level, with the number of simultaneously assayed protein markers far surpassing what can be measured by cytometry - based approaches.

The classification module is based on statistical classifiers, which can be «taught» to determine morphologic changes occurring within the culture even at the single cell level.

Interestingly we observed approximately a 2-fold change in Nanog transcript levels between the two populations, and thus while the V+S + cells appear Nanog negative based on antibody staining, they still express some Nanog transcript.

A web - based tool in which users can upload their individual SNP data and obtain predicted expression levels for the set of predictable genes across the 14 different cell types.

The reason for the difference in the fold change in ULK1 RNA levels observed in WT and DAXX K / D PC3 cells between the RNA - Seq and Q - PCR analyses is unclear, but we believe that the Q - PCR result is reliable based on the replicates we obtained.

Moreover, in PrEn precursors, the Nanog low population can itself be split based on the expression of Oct4 or SSEA - 1 into a state expressing reasonably high level of PrEn genes (V+S −), and a less differentiated cell type exhibiting a PrEn bias, but with similar regenerative capacities to the Nanog high population (V+S +).

We use an ES cell line in which low levels of Hex transcript are visualized based on the expression of the enhanced YFP, Venus coupled to a unique translational amplifier.

The rapid test is based on a new plastic microfluidic chip where bacteria from a urine sample are trapped and methods for analysing their growth at single - cell level.

I want to help take stem cell - based tissues to the next level — to generate technologies that are actually being used by industry and are being implemented for the manufacturing of stem cell - based products.

Cells were first gated based on forward and side scatter properties and then Thy1.2 negative cells were analyzed for levels of GCTM2 and TG30 labeCells were first gated based on forward and side scatter properties and then Thy1.2 negative cells were analyzed for levels of GCTM2 and TG30 labecells were analyzed for levels of GCTM2 and TG30 labeling.

Overall, these results indicate that changes in ATP levels are a reliable indicator of cell death in stem cell populations upon drug insults and may have utility for hESC - based automatic screening assays.

In The Answer to the Pritikin Puzzle, we established that the reason the blood of those eating plant - based diets appeared so much better at fighting cancer cell growth (see Ex Vivo Cancer Proliferation Bioassay) is likely due to the drop in IGF - 1 levels, especially in those following vegan diets (see How Plant - Based to Lower IGF -based diets appeared so much better at fighting cancer cell growth (see Ex Vivo Cancer Proliferation Bioassay) is likely due to the drop in IGF - 1 levels, especially in those following vegan diets (see How Plant - Based to Lower IGF -Based to Lower IGF - 1?).

Same exact genes, but those eating more plant - based diets had more favorable levels of this hormone, secreted by human fat cells, that helps control weight.

NightFX Renewal Serum contains therapeutic levels of plant - based squalane, which has been shown to help keep skin cells hydrated while dramatically improving the skin's texture and appearance, reducing roughness, fine lines and wrinkles.

Switching people to a plant - based diet can significantly lower IGF - 1 levels within just 11 days, markedly improving the ability of women's bloodstreams to suppress breast cancer growth, and then kill breast cancer cells off.

This product uses the technology of fruit base cells to help nurture and feed the skin at a much deeper level and leave it smoother on the surface.

The kidney is also responsible for blood pressure regulation as well as ensuring you have a correct acid base balance (pH levels); kidneys even stimulate the production of red blood cells within your body.

Not only do the foods you put in your body influence your appearance, mood, energy levels and wellbeing on a day - to - day basis, they literally become the proteins that make up the cells that are your skin, heart, brain, lungs, liver and other organs.

Based on that physical, whether your animal is sick or well, we recommend blood tests to evaluate organ function, protein levels, electrolytes, blood cell counts, thyroid levels, urinalysis, heart worm infection, tick borne diseases and feline infectious diseases.

Prepare to battle and defeat extreme nemeses including the Black Nucleus, Hyper Blobs and Spore Plants using powerfulIn Nano Assault, players blast their way through 32 twisted cell stages and dark worlds with rugged landscapes that adjust in difficulty based on the player's skill level.

The game's levels were created using a program called CED, a cell editor made by CEO Mike Morhaime that Blizzard used to lay out levels, which later went on to be the basis of the Warcraft and StarCraft map editor.

Nano Assault ™ challenges players through 32 twisted cell stages and dark worlds with rugged landscapes that adjust in difficulty based upon the player's skill level.

-- \» Bacteria World \» is online game based on original \» Spore \» principles — The rule of this world is simple: become the biggest bacteria — Eat smaller cells and run from bigger — Level - up your character — Emoticons chatting — Smooth online multiplayer gameplay — Nice skins — Cool and deformable bacterias — Online leaderboard — No annoying ads Controls: — Move with left pad — Split and shoot mass with double - touch ------- Coming soon: — Clan game mode — Clan ratings — New game modes — New Skins!

The largest U.S. solar cell installation today is a 14 - megawatt array at Nellis Air Force Base in Nevada, but photovoltaic electricity at the commercial level is about to go big time.

Indeed, this analogue might lead to a double error when temperature grid cells were area weighted and the lapse correction for levelling to a fixed altitude (if used) was based on area weighted altitude calculations, instead of point locations where stations were sited.