Sentences with phrase «cell lineage differentiation»

Not exact matches

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

The International Human Epigenome Consortium presents a series of studies on how epigenetics influences immunity, cell lineage determination, and differentiation.

Directed and step-wised differentiation of embryonic stem cells toward neuronal, cardiac and pancreatic lineages

«Irreversible resolution of lineage priming appears to be a common feature of blood cell differentiation and may in fact be a general feature of other developmental processes.»

The quickest, most efficient way to micromanage the cells» developmental decisions was to apply a simultaneous combination of factors that both encouraged the differentiation into one lineage while also actively blocking the cells from a different fate — a kind of «yes» and «no» strategy.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

Highly Synchronized Expression of Lineage - Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines.

«What is more, the technique identifies key genes and enriched gene ontology pathways, as well as categories related to stem cell differentiation — and specifically toward osteochondral lineages (that is, related to bone and cartilage tissue growth).»

Identification of common pathways mediating differentiation of bone marrow - and adipose tissue - derived human mesenchymal stem cells into three mesenchymal lineages.

Embryonic stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal

(C) Directed differentiation of iPS cells of line 11.1 into neural lineages.

We were particularly interested in stem cell self - renewal, differentiation, and lineage choice.

We are particularly interested in stem cell self - renewal, differentiation, and lineage choice.

VASA expression increased during the differentiation of monkey ES cells, indicating that these cells have the ability to differentiate into a germ cell lineage in vitro.

The origins of many of these and other genes specific to animal processes such as cell adhesion, and social control of cell proliferation, death and differentiation can be traced to genomic events (gene birth, subfamily expansions, intron gain / loss, and so on) that occurred in the lineage that led to the metazoan ancestor, after animals diverged from their unicellular «cousins».

More particularly, we have developped a protocol to induce efficicent and synchronized differentiation of PSC into the neural lineage in order to capture stable populations of self - renewing neural stem cells (NSC).

That this occurs once cells enter differentiation, is consistent with a requirement for sustained FGF signalling for commitment and segregation of the PrEn lineage in cultured blastocysts [57].

In this way embryo - derived stem cell lines and ES cell differentiation may be providing access to potential «transition states,» required for lineage specification in vivo.

He has been a leader in applying molecular and genetics tools to study the immune system including specification of T lymphocyte lineages, the differentiation of inflammatory T helper cells, the role of microbiota in regulating immune responses, and the mechanisms of HIV entry and pathogenesis.

We are currently involved in a collaborative research programme with Cellectis biotech company aiming at genetically modifying hiPS cells in order to optimize differentiation protocols into particular cell lineages and allow the isolation of homogenous cell populations of interest.

However, when these fractions are placed into differentiation either in vivo or in vitro, the V+S + population tends to colonize the PrEn lineages, while V − S + cells tend towards epiblast.

To further examine the differentiation of ES cells into a germ cell lineage, EBs were stained with anti-VASA antibodies.

In general, adult stem cells have low plasticity, although reports of differentiation outside traditional lineage boundaries suggest that some adult stem cells may be more pluripotent rather than multipotent.1

When the culture is removed from the constraints of self - renewal, lineage primed states drive commitment to a direction of differentiation based on the location of a cell in a specific state or attractor.

Our group will be responsible for an entirely automated cell culture platform, the CompacT SelecT devoted to the amplification of hES and hiPS cells and their differentiation into various cell lineages.

Based on previous protocols [5, 6] they have now created a 3D protocol for chondrogenic lineage differentiation via the generation of a putative chondrogenic progenitor cell population, and have found that using this protocol C - iPSCs can be readily differentiated into cartilage in a manner comparable to that of mature chondrocytes [7].

Here, we used a marker - free approach to computationally reconstruct the blood lineage tree in zebrafish and order cells along their differentiation trajectory, based on their global transcriptional differences.

During that time, she applied her knowledge of the processes governing normal heart development to direct the differentiation of embryonic stem cells into the cardiac lineage.

Recent studies of the ES cell transcriptome and epigenome have revealed networks of co-regulated transcription factors that maintain pluripotency and suppress the expression of genes associated with particular differentiation lineages [2].

It is probable that these cells represent extraembryonic endoderm, and that they arise directly from stem cells primed to differentiation into this lineage.

Bone marrow - derived mesenchymal stem cells (BMDMSC) are of particular interest in orthopedics, as cells in this lineage are involved in osteogenic differentiation of cells at the site of bone generation and regeneration.

Student, «Characterizing the macrophage response to peripheral nerve injury» Gat Rauner, Postdoc Assoc., «Cell Hierarchy, Lineage Commitment and Differentiation in the Bovine Mammary Gland» Lunch provided with sign up - please contact Sue Williams at [email protected] or 256-5600

Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem / Progenitor Cells after Loss of Mechanical Loading?