Not exact matches
The genes are likely to be expressed when
cells differentiate into neural crest
lineages,
such as neurons or Schwann
cells, thereby enabling researchers to study the disease in a dish.
Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control
lineage regulatory regions; our model predicts many already known
lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation
such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK
cells.
Resident macrophages from the same
lineage,
such as liver Kupffer
cells, brain microglia, epidermal Langerhans
cells, lung alveolar macrophages..., display tissue - specific phenotypes, perform tissue - specific functions and have distinct gene expression profiles.
Diagnosis of BPDCN was confirmed by the positivity of the
cells for CD4 and CD56, along with other markers that are more restricted to plasmacytoid dendritic
cells (
such as CD123), and the negativity of the
cells for lymphoid, NK and myeloid
lineage - associated antigens.
Currently, we are exploring several environmental samples retrieved from allover the world - ranging from hydrothermal vents in Japan to hot springs in Yellowstone National Park and New Zealand — for the presence of novel archaeal (and bacterial)
lineages using cultivation - independent approaches,
such as metagenomics and single
cell genomics.
Studying the epigenetic setting of germ
cells allows investigating several crucial aspects of mammalian biology
such as transposon control, genomic imprinting and early
lineage commitment.
These mutant mice may be useful in monitoring the Cre expression in living tissues, and tracing the
lineage of
such cells in embryos, young, and adult mice at desired time points.
The origins of many of these and other genes specific to animal processes
such as
cell adhesion, and social control of
cell proliferation, death and differentiation can be traced to genomic events (gene birth, subfamily expansions, intron gain / loss, and so on) that occurred in the
lineage that led to the metazoan ancestor, after animals diverged from their unicellular «cousins».
Our results also suggest that
such a strategy is rich in the potential of identifying
lineage specific reagents and provides additional evidence for the utility of stem
cells in screening and discovery paradigms.
San Diego, CA (March 31, 2009)-- Novocell, Inc., a stem
cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm
cells, an essential
cell for generating not only pancreatic type
cells, which Novocell is developing for use as a
cell therapy for diabetes, but also other endoderm
lineage - derived tissues and organs
such as lungs, intestine, liver, thymus and thyroid.
While this approach did not allow us to examine the impact of selective EBI2 - deficiency in DCs on WT B -
lineage cells, the experiment did allow assessment of the response of EBI2 - deficient B
cells in mice that lack EBI2 on CD11c + DCs while retaining EBI2 on approximately half of all non-CD11c expressing
cells (
such as helper T
cells).