Sentences with phrase «cell lineage trees»

This could ultimately help us to understand which mutations in a patient cause permanent damage to cell lineage trees.

Not exact matches

With DNA evidence as solid as that used to convict criminals, researchers can trace the shared genetic lineage of life's different branches back to the very base of the tree, some 4 billion years ago, when the interaction between primordial bacteria and viruses culminated in the «mother cell,» the common ancestor of all life on Earth.

Typically the process of tracking cell lineage over time requires biologists to watch the time - lapse images and note by hand when the cells multiply - creating a graphic representation of cell division over time called a «lineage tree.»

For example, assaying the genomes of multiple cells during development reveals developmental lineage trees - the kinship lineage - whereas cellular transcriptomes inform us about the regulatory state of cells and their gradual restriction in potency - the Waddington lineage.

Here, we used a marker - free approach to computationally reconstruct the blood lineage tree in zebrafish and order cells along their differentiation trajectory, based on their global transcriptional differences.