Sentences with phrase «cell lineages in»

The researchers hypothesize that in older people, many of the cell lineages in the blood have reached their maximum number of cell divisions and died off, leaving the ones that have divided more slowly and, therefore, have accumulated fewer mutations.

Then, they transplanted these cells into recipient mice and confirmed that the cells can form all of the blood cell lineages in vivo.

COURTESY SHENDURE AND SCHIER LABS CRISPR FOR FATE - MAPPING Researcher: Jay Shendure, Professor, Department of Genome Sciences, University of Washington Project: In collaboration with Alexander Schier's lab at Harvard University, Shendure's group came up with a new way to trace cell lineages in cell culture and in whole organisms — in this case, developing zebrafish.

The reason is that embryonic stem cells naturally want to make neuroectoderm, a cell lineage in the embryo that forms the nervous system.

VASA expression increased during the differentiation of monkey ES cells, indicating that these cells have the ability to differentiate into a germ cell lineage in vitro.

SSEA1 -, OCT - 4 -, and VASA - positive cells were detected in the EBs, indicating that monkey ES cells have the ability to differentiate into a germ cell lineage in vitro.

Not exact matches

The lineage of scientific explanations discussed in the episode runs from Newton through Darwin, Einstein, chaos theory and, most recently, Murray Cell - Mann, whose Santa Fe Institute devotes itself to the sciences of complexity.

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

In a study published in Cell Reports, researchers lead by Cédric Blanpain, MD / PhD, WELBIO investigator and Professor at the Université libre de Bruxelles, Belgium, identified a novel lineage - restricted stem cell in the mammary glanIn a study published in Cell Reports, researchers lead by Cédric Blanpain, MD / PhD, WELBIO investigator and Professor at the Université libre de Bruxelles, Belgium, identified a novel lineage - restricted stem cell in the mammary glanin Cell Reports, researchers lead by Cédric Blanpain, MD / PhD, WELBIO investigator and Professor at the Université libre de Bruxelles, Belgium, identified a novel lineage - restricted stem cell in the mammary glCell Reports, researchers lead by Cédric Blanpain, MD / PhD, WELBIO investigator and Professor at the Université libre de Bruxelles, Belgium, identified a novel lineage - restricted stem cell in the mammary glcell in the mammary glanin the mammary gland.

It is generally accepted that paternally imprinted X inactivation occurs exclusively in extraembryonic lineages of mouse embryos, whereas cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivation.

The two postembryonic touch receptor neurons in the nematode Caenorhabditis elegans arise from essentially identical cell lineages and have the same ultrastructural features.

In this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenancIn this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenancin Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenaCell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenacell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenance.

«If ctenophores diverged first, these organ systems likely have been present in the common ancestor of all animals — and sponges and placozoans must subsequently have lost them — or complex traits like nerve cells and muscles must have emerged independently several times in different lineages,» Wörheide explains.

The enzyme was tested in three different cell lineages: leukemia cells incapable of producing asparagine at normal levels (MOLT4); another line of leukemia cells, in this case capable of producing asparagine at normal levels (REH); and non-malignant cells, used as a control (HUVECs).

In this process, several hundred times more cells of the so - called myeloid lineage (thrombocytes, erythrocytes, granulocytes, monocytes) form than long - lived lymphocytes (T cells, B cells, natural killer cells) do.

With DNA evidence as solid as that used to convict criminals, researchers can trace the shared genetic lineage of life's different branches back to the very base of the tree, some 4 billion years ago, when the interaction between primordial bacteria and viruses culminated in the «mother cell,» the common ancestor of all life on Earth.

«By harnessing the lineage tracing methods that are available in the fly, he was able to adapt them to label the glia and motor neurons that are born from the same stem cell in two different colors.»

Pancreatic cancer cells are known to emit signals that shift the lineage of in - rushing macrophages from M1 to immune - suppressing M2.

By March 2014 — about the time the epidemic was detected, but some 3 months after the first case actually occurred — the sequences had split into two distinct lineages, one of which was characterized by a single amino acid change in a region of the virus's surface protein and allows it to bind to cells.

Relative to reactions on naked DNA, there are changes (protections and enhancements) in the reactivity of guanine residues to dimethyl sulfate within the enhancer sequence in myeloma, B, and early B cells, whereas virtually no alterations appear in cells of non-B lineage.

All the muscles of our faces develop from a strip of cells at the base of the embryonic head, just as they do in lampreys, which belong to one of the oldest lineages of vertebrates alive today.

This could ultimately help us to understand which mutations in a patient cause permanent damage to cell lineage trees.

He and his colleagues, including Janelia postdoc Fernando Amat, Janelia group leader Kristin Branson and former Janelia lab head Eugene Myers, who is now at the Max Plank Institute of Molecular Cell Biology and Genetics, have used the methodto reconstruct cell lineage during development of the early nervous system in a fruit Cell Biology and Genetics, have used the methodto reconstruct cell lineage during development of the early nervous system in a fruit cell lineage during development of the early nervous system in a fruit fly.

So confused is the genetic history of llamas that some are in fact chimeras; they have cells in their bodies from two distinct maternal lineages.

The technique is based on scars in the DNA, which taken together work like a bar code from which each cell's lineage can be determined.

Thus, in principle, a successful vaccine has to stimulate the first B cells in this lineage and then coax them along a fairly narrow evolutionary path until they have changed enough to provide effective protection against HIV.

Andrabi therefore analyzed how B cells in the VRC26 lineage changed in CAP256's blood in the course of HIV infection.

«There's no shared common descent between species, since every single creature in Spore can trace its lineage back to a different single - celled organism that arrives from space.»

Blood founder cells showed a much lower propensity for aberrant methylation than did other founder cells, which could explain why in the past scientists attributed the founder cell to the effectiveness of differentiating iPS cells to the hematopoietic lineage.

Mice from one vendor, for example, were notably lacking segmented filamentous bacteria (SFB), a commensal lineage recently shown to help mice produce key antibodies and immune cells in their intestines.

These findings suggested that exhausted T cells are a distinct lineage of T cells in and of themselves instead of just being effector or memory T cells restrained by checkpoint pathways.

The team's model, still in its early stages, is hoped to form a foundation for continuing studies on germ cell lineage.

The genes are likely to be expressed when cells differentiate into neural crest lineages, such as neurons or Schwann cells, thereby enabling researchers to study the disease in a dish.

In effect, this is gene therapy, since the donor's genes are replacing the patients genes in the blood cell lineageIn effect, this is gene therapy, since the donor's genes are replacing the patients genes in the blood cell lineagein the blood cell lineages.

It has long been suspected that changes to cells of the monocyte / macrophage lineage, a type of immune cell, influence the development of cognitive impairment in HIV.

The identity of the cells was further confirmed by lineage tracing experiments, where the reprogrammed cells were implanted in chicken embryos and acted just as neural crest cells do.

It provides insights into how to transform stem cells into therapeutically useful cells and suggests possible new treatments for leukemias, in which a persistent mixed lineage seems to drive cancerous proliferation.

Lead author found guilty of misconduct in embryonic cell lineage paper called into question over a year ago

«Irreversible resolution of lineage priming appears to be a common feature of blood cell differentiation and may in fact be a general feature of other developmental processes.»

The discovery that lineage - related melanoma antigens can be recognized by patients» T cells then opened the way to their use in melanoma immunotherapy.

These results suggest that by using the correct combination of gene products, it may be possible to reprogram more readily available pluripotent cell types to a multipotent retinal cell lineage useful in healing damaged or diseased retinas.

But when the daughter cells are mated and genetic reassortment takes place, they can subsequently pass along this same trait without the prion — that is, the trait becomes fixed in the cell's lineage and no longer depends on the prion state.

The Scientist spoke with the developers of four recent applications of single - cell lineage tracing experiments — examples that reflect the power biologists have in 2016 to answer fundamental questions about how tissues and organs form.

Given our model results, we speculate a relationship between adhesion and the variance of cell lineage cluster size, which could determine the ability of microbes to cope with variability in nutrient patchiness [62 — 65].

For example, intra-strain cooperative behaviors are more likely to be evolutionarily stable when different cell lineages are segregated in space, with typical interaction distances between cells being strongly influenced by the diffusivity of secreted products, biofilm architecture, and environmental flow conditions [16 — 19].

By carefully guiding the cells» choices at each fork in the road, Loh and Chen were able to generate bone cell precursors that formed human bone when transplanted into laboratory mice and beating heart muscle cells, as well as 10 other mesodermal - derived cell lineages.

Noggin is a key component in the cocktail used to bias human ES cells to a retinal lineage, and we found it was also sufficient to direct Xenopus pluripotent cells to retinal cell classes and eventually functional eyes.

In that context, the goal of this project is to infect relevant human host cells (monomacs, neuronal stem cells and differentiated neurons) with parasites of differing lineages to generate transcriptional mRNA and miRNA profiles.

In this regard, comprehensive cell lineage tracking experiments will significantly promote our current knowledge regarding the in vivo origin and function of MSCIn this regard, comprehensive cell lineage tracking experiments will significantly promote our current knowledge regarding the in vivo origin and function of MSCin vivo origin and function of MSCs.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.