Sentences with phrase «cell lineages of»

Title: Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin Authors: Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H Date: March 2010 Publication Details: Science.

A whole network of these proteins is involved in giving embryonic stem (ES) cells pluripotency — the ability to generate all the cell lineages of the body.

This latest study reports the generation of multiple cell lineages of the eye, including the lens, cornea, and conjunctiva, using human induced pluripotent stem cells.

Not exact matches

To the contrary, it is more fantastic than we can imagine — hundreds of billions (trillions) of galaxies with hundreds of billions (trillions) of stars, nearly all of which have planets, some right for life; planets so hot that they rain glass; stars made of diamonds; the lineage of animals from singled celled organisms to the incredible variety that exists today with their unique adaptations.

The lineage of scientific explanations discussed in the episode runs from Newton through Darwin, Einstein, chaos theory and, most recently, Murray Cell - Mann, whose Santa Fe Institute devotes itself to the sciences of complexity.

Specifically, they use a technique called lineage tracing to mark stem cells and follow the fate of their progeny over time.

It is generally accepted that paternally imprinted X inactivation occurs exclusively in extraembryonic lineages of mouse embryos, whereas cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivation.

«To derive lineages, people use soluble growth factors to get the cells to differentiate,» explains Laura Kiessling, a UW - Madison professor of chemistry and biochemistry and stem cell expert.

In this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenaCell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenacell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenance.

«If ctenophores diverged first, these organ systems likely have been present in the common ancestor of all animals — and sponges and placozoans must subsequently have lost them — or complex traits like nerve cells and muscles must have emerged independently several times in different lineages,» Wörheide explains.

Her pioneering work mapping the regulatory network of dendritic cells (DCs) identified a lineage of DCs that is now considered a key target to improve antiviral and antitumor immunity.

The enzyme was tested in three different cell lineages: leukemia cells incapable of producing asparagine at normal levels (MOLT4); another line of leukemia cells, in this case capable of producing asparagine at normal levels (REH); and non-malignant cells, used as a control (HUVECs).

In this process, several hundred times more cells of the so - called myeloid lineage (thrombocytes, erythrocytes, granulocytes, monocytes) form than long - lived lymphocytes (T cells, B cells, natural killer cells) do.

Efforts to obtain and study genomes and enrichment cultures of uncultivated microbial lineages will likely further expand our knowledge about archaeal phylogenetic and metabolic diversity and their cell biology and ecological function.

This general approach, known as lineage - tracing, has been a mainstay of classical developmental biology research and has greatly clarified knowledge of tissue stem cells during the last decade.

With DNA evidence as solid as that used to convict criminals, researchers can trace the shared genetic lineage of life's different branches back to the very base of the tree, some 4 billion years ago, when the interaction between primordial bacteria and viruses culminated in the «mother cell,» the common ancestor of all life on Earth.

Pancreatic cancer cells are known to emit signals that shift the lineage of in - rushing macrophages from M1 to immune - suppressing M2.

By March 2014 — about the time the epidemic was detected, but some 3 months after the first case actually occurred — the sequences had split into two distinct lineages, one of which was characterized by a single amino acid change in a region of the virus's surface protein and allows it to bind to cells.

Relative to reactions on naked DNA, there are changes (protections and enhancements) in the reactivity of guanine residues to dimethyl sulfate within the enhancer sequence in myeloma, B, and early B cells, whereas virtually no alterations appear in cells of non-B lineage.

All the muscles of our faces develop from a strip of cells at the base of the embryonic head, just as they do in lampreys, which belong to one of the oldest lineages of vertebrates alive today.

This is a video of rotating view of neural precursor cell tracks obtained from the cell lineage reconstruction of early Drosophila embryonic nervous system development.

He and his colleagues, including Janelia postdoc Fernando Amat, Janelia group leader Kristin Branson and former Janelia lab head Eugene Myers, who is now at the Max Plank Institute of Molecular Cell Biology and Genetics, have used the methodto reconstruct cell lineage during development of the early nervous system in a fruit Cell Biology and Genetics, have used the methodto reconstruct cell lineage during development of the early nervous system in a fruit cell lineage during development of the early nervous system in a fruit fly.

So if another lineage of complex cells were to evolve when there was already a well - adapted lineage, the new arrival would probably...

All of these steps can be carried out as quickly as images are acquired by the microscope, and the result is lineage information for every cell.

Cohen, whose background includes developing operating systems support for computer games, has developed a program called LEVER - short for Lineage Editing and Validation program - that can identify, tag and track live cells, capturing patterns of motion and cell division, using sequences of microscopic time - lapse images.

They used their method to trace the lineages of 295 neuroblasts (precursors of nerve cells) and discovered that it is possible to predict the future fate and function of many cells based on their early dynamic behavior.

So confused is the genetic history of llamas that some are in fact chimeras; they have cells in their bodies from two distinct maternal lineages.

This video shows automated computational cell lineage reconstruction of the image data.

Only the lineage of each cell can tell the true story — the extent of the damage and the repair mechanism.

Typically the process of tracking cell lineage over time requires biologists to watch the time - lapse images and note by hand when the cells multiply - creating a graphic representation of cell division over time called a «lineage tree.»

But only after engaging the target and adjusting their antigen receptors over many generations (as B cells do by mutating their antigen receptor genes) can this lineage of cells produce VRC26 bnAbs.

The eye is composed of highly specialized tissues that are derived from a variety of cell lineages during development.

Andrabi therefore analyzed how B cells in the VRC26 lineage changed in CAP256's blood in the course of HIV infection.

While these mutations do not directly relate to the development or progression of a tumor, they can reveal its lineage — how individual tumor cells are related to each other.

The ability of a stem cell of one lineage to become another lineage is called transdifferentiation.

Blood founder cells showed a much lower propensity for aberrant methylation than did other founder cells, which could explain why in the past scientists attributed the founder cell to the effectiveness of differentiating iPS cells to the hematopoietic lineage.

«We get almost all lineages of blood cells that you would expect from bone marrow.»

Foremost is that it is one of the first to show the benefits of using human iPS cell - derived renal lineage cells for cell therapy.

Instead, they show the expression of certain genes and DNA methylations were better indicators of the efficiency at which a cell line could be differentiated into the hematopoietic lineage.

To trace the lineage of liver cells, scientists used a telltale marker — the cells» response to signals delivered by a known stem - cell regulator called Wnt.

It's a mystery,» he said, suggesting that it could mean stem cells thought to be committed to a particular lineage may be capable of becoming other types of tissue entirely.

These findings suggested that exhausted T cells are a distinct lineage of T cells in and of themselves instead of just being effector or memory T cells restrained by checkpoint pathways.

«Thanks to a genetically - modified mouse that makes the HMX3 lineage visible, we could uncover the origins of neurogliaform cells.

Using FACS we also found that all of the F4 / 80 + cells coexpressed the common leukocyte antigen CD45 and the monocyte lineage marker CD11b (data not shown).

It has long been suspected that changes to cells of the monocyte / macrophage lineage, a type of immune cell, influence the development of cognitive impairment in HIV.

The International Human Epigenome Consortium presents a series of studies on how epigenetics influences immunity, cell lineage determination, and differentiation.

The identity of the cells was further confirmed by lineage tracing experiments, where the reprogrammed cells were implanted in chicken embryos and acted just as neural crest cells do.

Directed and step-wised differentiation of embryonic stem cells toward neuronal, cardiac and pancreatic lineages

COURTESY SHENDURE AND SCHIER LABS CRISPR FOR FATE - MAPPING Researcher: Jay Shendure, Professor, Department of Genome Sciences, University of Washington Project: In collaboration with Alexander Schier's lab at Harvard University, Shendure's group came up with a new way to trace cell lineages in cell culture and in whole organisms — in this case, developing zebrafish.

This effort will combine deep knowledge of immunological lineages, clinical expertise and infrastructure needed to procure and process diverse samples, genomic and computational expertise to resolve the hundreds of finely differentiated cell - types that compose all facets of the immune system, and the genomic signatures that define them.