Sentences with phrase «cell lines in»

They will study canine genes of interesl to this pathway in both cOSA tumor specimens and cOSA cell lines in culture.

We've identified that ketone bodies, i.e. fuels in the bloodstream that result from a very low carbohydrate diet, metabolically inhibit growth of 7 cancer cell lines in cell culture, but not 3 normal cell types.

sorafenib induces cell death in human myeloma cell lines in a laboratory environment by preventing a certain kind of protein - level activity, an effect that also was achieved when the myeloma cells had developed a resistance to

Many researchers are already using stem - cell lines in drug development and to further understanding of often - complex diseases.

In the future, scientists may be able to modify human stem cell lines in the laboratory by using gene therapy or other techniques to overcome this immune rejection.

FRS, and William Skarnes, Ph.D., at the Wellcome Trust Sanger Institute, plans to systematically create mouse ES cell lines in which 5,000 genes have been knocked out by gene targeting.

Next, we demonstrated the expression of PSCA and MUC1 in NSCLC, followed by the generation and confirmation of the specificity and efficacy of PSCA - and MUC1 - targeting CAR T cells against NSCLC cell lines in vitro.

To assess the ability of F3 - IgG to inhibit the proliferation of HER2 - overexpressing breast carcinoma cells, we measured the proliferation of BT474, MCF7 / HER2 and MCF7 breast cancer cell lines in the presence of trastuzumab, F3 - IgG, or an isotype - matched control antibody.

Several carry fluorescent reporter transgenes that enable one to follow the cell lines in chimeras.

The researchers then analyzed another 147 colorectal cancer cell lines in the same way for kinase - domain mutations in these genes, and then sequenced the entire coding region of all kinases that were mutated, in all discovering 46 new mutations.

In a discovery screen profiling 102 cell lines against 8,400 compounds, PRISM led the researchers to a specific novel compound, BRD - 7880; the specific action against cell lines in the panel rapidly led them to discover that this compound worked by inhibiting aurora kinase B, an enzyme involved in cell division that is abnormally regulated in several cancers.

It was indeed found DAXX promotes the in vivo tumorigenicity of two human PCa cell lines in a subcutaneous tumor xenograft model via suppression of autophagy [Submitted].

Evidence demonstrating its cytostatic activity includes the finding that it inhibits the growth of a broad spectrum of human tumor cell lines in vitro.

Registration of cell lines in hPSCreg will provide visibility, confidence in ethical provenance, validation of characterization data and comparability with other registered lines.

RASSF1A overexpression reduces in vitro colony formation and the tumorigenicity of cancer cell lines in vivo.

They fused mouse B cells — antibody - producing cells of the immune system — with human myeloma (also known as B cell cancer) cell lines in a new technique called hybridoma technology.

The most radical news at the conference was the first reported use of CRISPR / Cas9 to generate precise genome edits (changing only a single base pair) in two genes, not only in cell lines in vitro, but also in specific tissues of embryos in ovo.

For while the new NIH guidelines explicitly permit funding for research on stem cell lines in which human embryos have already been destroyed, they also explicitly forbid funding for research on stem cell lines that have been produced by SCNT (see section V. part B).

The group urged the creation of two central databases: One on stem cell lines in use worldwide and one on intellectual property rights so scientists can readily access information.

They tested 120 neural stem cell lines in the lab for stability and robustness and in animals for the capacity to engraft with minimal immune rejection.

On 11 March, the European Molecular Biology Laboratory (EMBL) issued a press release proudly announcing that a research team there had deciphered much of the genetic sequence of one of the most widely used cell lines in cancer studies and had made the information available publicly.

Working with mouse prostate cancer cell lines in the laboratory, the investigators found that cells containing overexpressed TOP2A and EZH2 genes were highly sensitive to attack with a combination of two drugs.

Our investigations on human cell lines in the laboratory have shown that synthetic cannabinoids, in the high concentrations found in cells in the oral cavity or in the lungs, for example, are likely to trigger damage to the DNA that may have significant consequences for the consumers of such substances.

Using cutting edge «disease in a dish» technologies, the researchers are now following up the leads discovered in blood cell lines in neurons induced from stem cells derived from the blood of PMDD patients — in hopes of gaining a more direct window into the ESC / E (Z) complex's role in the brain.

And a Singapore - based group created six clinical - grade cell lines in 2007, also using animal products.

Many researchers are already using stem cell lines in drug development, and to further understanding of often - complex diseases.

When Sukumar and the others depleted the HOXA5 protein in other breast cell lines in the lab, the cells became more immature, or «stem like,» as well as more mobile.

HeLa cells are the most widely used human cell lines in existence today.

India's biotechnology secretary had earlier told Science she knew of no such cell lines in the country.

There are many hundreds, if not thousands, of different stem cell lines in use around the world.

But its most immediate use could be to flag mislabeled or contaminated cell lines in cancer experiments, a major reason that studies are later invalidated.

«We've seen this in six different types of human cancer cell lines in the lab,» Choudhury said.

Through these effects, the PERY peptide reduced the proliferation of several (but not all) cancer cell lines in culture and inhibited the growth of a human breast cancer xenograft in mice.

Focusing on energy - transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically - approved drug stiripentol, 3 natural products — caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid — and experimental pharmaceuticals, such as actinonin, FK866 and 2 - DG.

The 78 stem cell lines in existence would qualify for government - financed research, he said, but no additional money would be provided for additional cell lines.

Due to the 2.5 GW exemption for imported cells, there is no more reason to install cell lines in the U.S. than there was before the Section 201 process.

And early stage startup Neochromosome, which includes Boeke, intends to raise money to design synthetic chromosomes for medicine that could be used in an off - the - shelf universal cell line in cell therapies and transplants with minimal risk of rejection from the immune system.

A new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in lambda gt11 phage to derive molecular cDNA clones representing a putative B lymphocyte - specific octamer binding protein.

Since their isolation in 1951, HeLa cells have been the most widely used human cell line in research.

We found that the U87MG cell line from ATCC had a different DNA profile than the original cell line in Uppsala», says Bengt Westermark.

«It conclusively proves that the stem cell line in question was not cloned as claimed, but rather was generated through parthenogenesis.»

The cell line in question is known as HeLa, after an African - American woman named Henrietta Lacks.

The scientists were thus able to transfer the genetic information from the known fluorescent protein eqFP615 into the DT40 chicken B cell line in order to produce protein variants of the new infrared marker Amrose with different spectral properties.

We have traced the intracellular journey of endogenous ATP7A in enterocytes in vivo and in a polarized intestinal cell line in vitro by manipulating the extracellular copper levels.

Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line in vitro.

Registration of a cell line in hPSCreg confirms ethical procurement and scientific evidence for pluripotency to the global community.

Designing phase I clinical trial with transplantation of candidate cell line in Parkinson's disease This year's workshop will take place on September 12th and 13th in London.

We use an ES cell line in which low levels of Hex transcript are visualized based on the expression of the enhanced YFP, Venus coupled to a unique translational amplifier.

Designing phase I clinical trial with transplantation of candidate cell line in Parkinson's disease

Based on this analysis, it was mistakenly deduced that XMRV could not have originated from LNCaP or another cell line in the laboratory.