Sentences with phrase «cell lines resulting»

Stem cell lines resulting from a pathbreaking collaboration beginning in 2014 between The NYSCF Research Institute and the Charcot - Marie - Tooth Association (CMTA) are now available for use...

Stem cell lines resulting from a pathbreaking collaboration beginning in 2014 between The NYSCF Research Institute and the Charcot - Marie - Tooth Association (CMTA) are now available for use by other researchers in the largest and first ever initiative of its kind.

Not exact matches

«Our study results are the first to argue that we may be able to treat inflammatory bowel disease and protect against transplant rejection not only by blocking TNF alpha as is done currently, but also by stimulating ATG16L1 to prevent early death of cells lining the gut,» says study senior investigator Ken Cadwell, PhD, an associate professor at NYU School of Medicine and NYU Langone Health's Skirball Institute for Biomolecular Medicine.

CCG is also developing cell lines that are cultured to represent tumor behavior in vivo, and computational methods that will help researchers understand tumor behavior and apply the resulting data to diagnoses, treatments, and cures.

Although the researchers emphasized that laboratory results involving cell lines and mice do not necessarily translate to human treatment, they say their findings show that new mTOR inhibitors combined with chemotherapy could become a new treatment strategy for T - ALL.

This results in shifts in the structure of the brain as it forms and displacement of cells from where they're supposed to be, including those that line the ventricles and help control fluid flow.

Hwang claimed his stem cells did not result from parthenogenesis, but George Daley, head of the study, showed that the genome of Hwang's cell line has a genetic signature that indicates it sprang from a parthenogenetic embryo.

As a result, every cell in the iPS cell line will contain the same mitochondrial DNA mutations as that initial adult cell.

«Our study results suggest a new drug cocktail that is effective in both human lung cancer cell lines and fly models,» says Cagan.

The laboratory process, described in the journal Scientific Reports, entails genetically modifying a line of human embryonic stem cells to become fluorescent upon their differentiation to retinal ganglion cells, and then using that cell line for development of new differentiation methods and characterization of the resulting cells.

The successful prostate cell line that resulted from this event, named «22rv1,» was thus infected with a hybrid, lab - created virus: XMRV.

As a result, many of the studies published up to now describe only two or three patient stem cell lines,» says David Panchision, who oversees the NIMH's National Cooperative Reprogrammed Cell Research Group (NCRCRG) program, which supported this wcell lines,» says David Panchision, who oversees the NIMH's National Cooperative Reprogrammed Cell Research Group (NCRCRG) program, which supported this wCell Research Group (NCRCRG) program, which supported this work.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

The causes of such unpredictable results, Harris said, can include bad ingredients in the lab, including contaminated and misidentified cell lines; poor research design, including insufficient numbers of mice in animal studies; statistical error and overreach, including «HARKing» (hypothesizing after the results are known), a push beyond the limits of the data; and funding pressures, which can lead scientists to hype or exaggerate their results to remain competitive for additional grant money.

Their studies indicate that the two conditions common in sickle cell disease, dramatically increase red blood cells» adhesion to the lining of blood vessels walls and the debilitating pain crises that can result.

In experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regression.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

Genomic data from the HeLa cell line are also being released with the final version of the paper as a result of discussions between leaders of the National Institutes of Health (NIH) and relatives of Henrietta Lacks, from whose cervical tumor the original HeLa cell line was derived prior to her death in 1951.

Many scientific journals require researchers who report results based on cell line experiments to use DNA profiling to establish the identity of the used cells.

But it is inevitable that results obtained in one cell line might not exactly match those in another.

All human cell lines growing in tissue culture dishes, and about 95 % of cells in a human being, split evenly, resulting in daughter cells of equal size.

«We set out to test this in cell lines derived from mice and humans, and came up with a result we definitely did not expect — which then led us to dig deeper for answers.»

Craig Venter and his teams at the J. Craig Venter Institute in Rockville, Maryland, and San Diego, California, have shown themselves to be technical wizards by synthesising a genome from code contained on a computer, and using it to start a cell line of the resulting synthetic organism (see «How the synthetic bacterium was made»).

As a result, in late June, more than a year after Science retracted the 2004 paper, researchers at ISC were able to claim the discovery of human parthenogenetic cell lines as their own in the journal Cloning and Stem Cells.

However, it is notoriously difficult to maintain the integrity of cell lines — due to contamination or simple mistakes such as mislabeling, later generations of a cell line may bear no resemblance to the original sample, potentially invalidating results of research performed on mistaken cells.

Over the next few months, Wilmut's team confirmed that Dolly was a clone of the mammary cell line, and wrote up the results.

As a result, cell phone makers do not offer many models that have adequate processing power to run video smoothly, and digital cameras in U.S. cell phones are on the opposite side from the display screen (which would make it impossible to see the person on the other end of the line while exchanging sign language).

«We apologized for any distress experienced by the family as a result of our recent publication of the genome sequence of a HeLa cell line.

For the study published in Traffic, the researchers did not use pluripotent cells lines derived from Gulf War veterans, but said they plan to use veterans» cells in the future for more refined results.

These results were reproduced in three experiments with the three cell lines.

The results, although still preliminary in a quantitative sense, demonstrate that the reactivation of methylation - silenced genes does occur in different cell lines, suggesting it is a general phenomenon.

The protein encoded by the PIK3C2G gene belongs to the phosphatidylinositol -4,5-bisphosphonate 3 - kinase (PI3K) family, which plays a critical role in cancer.28 Experimental evidence suggests that activation of PI3K signaling enhances production of COX - 2 and PGE2, which results in inhibition of apoptosis in colon cancer cell lines that can be restored with NSAID - mediated blockade of PI3K.29

The resulting endothelial cell lines described in this study retain their phenotype after repeated passage, require minimal nutritional support and, importantly, may be useful for identifying factors that regulate endothelial cell proliferation and tumor cell adhesion in different anatomical regions.

The results have also been confirmed in cell lines and mouse models.

Results from a study published in Science Translational Medicine show that the publicly available cell line U87MG does not originate from the cell line it is claimed to do.

The National Infrastructure PHENOMIN is pleased to announce the results of its 6th Call: Generation and Characterization of CreERT2 cell specific promoter driven deleter mouse lines.

Mycoplasma compete with host cells for nutrients and can alter expression of receptors, ion channels, and growth factors resulting in changes to the cell line's growth and behavior.

Gesicle production can be performed in any 293T - based cell line, but we recommend the Gesicle Producer 293T Cell Line for optimal production resucell line, but we recommend the Gesicle Producer 293T Cell Line for optimal production resuline, but we recommend the Gesicle Producer 293T Cell Line for optimal production resuCell Line for optimal production resuLine for optimal production results.

Identification of small molecule inhibitors of Cisplatin - induced hair cell death: results of a 10,000 compound screen in the zebrafish lateral line.

In the present work, our observations led us to conclude that inhibition of TRF2 abrogates the formation and maintenance of the spheroidal phenotype and loss of TRF2 results in down regulation of CSC characteristics when exposed to DNA damaging environment in HCT116 colon cancer cell line.

Single - cell seeding of edited hiPS cells in this system results in high survival of pluripotent, edited clones, yielding a diverse set of edited clonal lines.

This result was similar to recently published data from the Egli lab in New York, which used an alternative technique, that of maternal spindle transfer or MST in eggs prior to fertilization, where they also had one aberrant ES cell line where this occurred (out of 8).

Embryonic stems cells often contribute to the germ line, resulting in the production of some sperm carrying the extra DNA.

It should be said that stem cell lines are quite different from normal embryonic development and these results should be interpreted with caution.

These results provide the validity to the newly developed hypoxia / reoxygenation culture system for examining the regulation of CSCs in breast cancer cell lines by niche factors in the tumor microenvironment and developing differential targeting strategies to eradicate breast CSCs.

The use of higher resolution techniques, such as array CGH and, soon, whole genome sequencing, will enhance the ability of researchers to examine stem cell lines to determine which are best — least likely to result in diseases and other problems — to use in creating therapies for use in humans.

Treatment of the Karpas 299 and SU - DHL1 cell lines with increasing concentrations of rapamycin, an inhibitor of the mTOR - raptor complex, resulted in a marked concentration - dependent decrease of the phosphorylation levels of mTOR, p70S6K, 4E - BP1, and total eIF4E (Fig. 4A).

Infection of both cell lines with adeno - myrAkt resulted in substantially increased of Ser473p - AKT levels (A) associated with increased phosphorylation (activation) of mTOR, p70S6K, and rpS6 (B).

Of note, treatment of ALCL cell lines with rapamycin also resulted in a slight decrease of Ser473 phosphorylation of AKT.

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.