42) Garnis C, Lockwood WW, Vucic E, Ge Y, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL (2006) High resolution analysis of non-small
cell lung cancer cell lines by whole genome tiling path array CGH.
Shapiro GI, Koestner DA, Matranga CB, et al: Flavopiridol induces cell cycle arrest and p53 - independent apoptosis in non-small
cell lung cancer cell lines.
Scientists from the Cancer Research UK Manchester Institute, based at The University of Manchester and part of the Manchester Cancer Research Centre, teamed up with experts at AstraZeneca, as part of a collaboration agreed in 2010, to test a drug — known as AZD3965 — on small
cell lung cancer cells.
Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c - Kit in small
cell lung cancer cells.
Functional expression of CXCR4 (CD184) on small -
cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.
Together with oncologist William Pao, she uncovered differences in the growth dynamics of non-small
cell lung cancer cells that are either resistant or susceptible to the targeted drug Tarceva.
Autocrine / paracrine prostaglandin E2 production by non-small
cell lung cancer cells regulates matrix metalloproteinase - 2 and CD44 in cyclooxygenase -2-dependent invasion.
8) Shah P, Lockwood WW, Saurabh K, Kurlawala M, Shannon S, Waigel S, Zacharias W, Beverley LJ (2014) Ubiquilin1 represses migration and epithelial to mesenchymal transition of human non-small
cell lung cancer cells.
Not exact matches
This drug has already staked its claim in the world of next - gen «checkpoint inhibitor»
cancer treatments by besting rival Bristol - Myers Squibb's competing treatment Opdivo in advanced non-small
cell lung cancer (NSCLC).
Immune
cells modified by CRISPR - Cas9 were inserted into a
lung cancer patient at the West China Hospital in Chengdu in the hopes that they'll be able to fight tumors, and 10 people total will receive injections of CRISPR re-engineered
cells in order to assess the method's safety.
The medicines, which help unleash the immune system on
cancer cells, were tested in patients with advanced
lung cancer.
Researchers from the Sichuan University in Chengdu inserted the re-engineered
cells into a
lung cancer patient participating in a clinical trial at the West China Hospital on October 28th, according to Nature.
The company has been trying to win FDA approval for Opdivo to be used as a first option treatment for non-small
cell lung cancer (NSCLC).
The PD - 1 checkpoint inhibitor Keytruda hit its goals in a new trial in previously untreated non-small
cell lung cancer patients, beating chemo at staving off
cancer progression and extending patients» lives.
April 16 Merck & Co's immunotherapy Keytruda plus chemotherapy significantly improved overall survival versus chemotherapy alone in newly - diagnosed patients with advanced non-small
cell lung cancer in a highly - anticipated study that appears to cement the company's lead in the most lucrative oncology market.
With
lung cancer, for example, it wants to be able to resolve whether a test shows non-small-
cell lung carcinoma or small
cell lung carcinoma.
They'll also jointly market Pfizer's drug Xalkori, which is approved in more than 75 countries for treating non-small
cell lung cancer in patients with a certain genetic mutation.
Merck already has an FDA approved immunotherapy drug with KEYTRUDA, a treatment for non-small
cell lung cancer.
The biotech specialist said that its updated phase 2 data in a study of its poziotinib candidate treatment for non-small
cell lung cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form of the disease.
In a mid-stage trial, 16 of 37
lung cancer patients given a placebo ahead of standard chemo wound up hospitalized with severely low white blood
cell counts.
... In
lung cancer cell lines, CBD upregulated ICAM - 1, leading to...
«We feel it'll be able to help kill
cancer cells in 80 percent of breast
cancer patients,» said Dr. Olson, who added that their antibody has the potential to help kill
lung, colon, prostate and other
cancer cells, too.
«Our study suggests that epigenetic changes to
cells treated with cigarette smoke sensitize airway
cells to genetic mutations known to cause
lung cancers,» says Stephen Baylin, M.D., the Virginia and D.K. Ludwig Professor for
Cancer Research and professor of oncology at the Johns Hopkins Kimmel
Cancer Center.
Baylin and Johns Hopkins scientist Michelle Vaz, Ph.D., first author on the study, suspected that the interplay of epigenetic and genetic changes may occur when normal
lung cells develop into
cancer, but, Baylin says, the timing of such changes was unknown.
However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed
cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related
lung cancers.
Scientists at the Johns Hopkins Kimmel
Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer develo
Cancer Center say they have preliminary evidence in laboratory - grown, human airway
cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the
cells consistent with the earliest steps toward
lung cancer develo
cancer development.
Non — small
cell lung cancer may involve genetic aberrations that can be used to direct therapy.
A protein called YAP1 was previously shown to contribute to the growth of
lung cancer cells; however, it was unknown how YAP1 controls
lung cancer growth and progression.
Following their recent discovery of a protein pathway, Moffitt
Cancer Center researchers are one step closer to understanding how lung cancer cells metast
Cancer Center researchers are one step closer to understanding how
lung cancer cells metast
cancer cells metastasize.
Scientists from Moffitt reported in the Jan. 19 online edition of
Cancer Research that nicotine induces the metastatic spread of lung cancer cells by stimulating a protein called beta - arresti
Cancer Research that nicotine induces the metastatic spread of
lung cancer cells by stimulating a protein called beta - arresti
cancer cells by stimulating a protein called beta - arrestin - 1.
«Cause of chemoresistance in small
cell lung cancer discovered.»
E2F1 is known to contribute to the development of
cancer by promoting
cancer cell proliferation; however, this is the first time that E2F1 has been shown to contribute to metastasis of
lung cancer.
Many scientists believe that targeting a type of
cell called a
cancer stem
cell may be necessary to completely cure
lung cancer.
The researchers confirmed this hypothesis by showing that if they blocked YAP1 they could inhibit stem
cells from undergoing self - renewal, forming blood vessel - like structures, and reduce
lung cancer cell growth in mice.
Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small
Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy.
Moss has shown that animals lacking these receptors do not develop
lung cancer when injected with
cancer cells.
A late breaking subanalysis of the phase III CONVERT trial presented at the European
Lung Cancer Conference (ELCC) shows that white blood cell boosting drugs are safe during concurrent chemo - radiotherapy of small cell lung cancer (SC
Lung Cancer Conference (ELCC) shows that white blood cell boosting drugs are safe during concurrent chemo - radiotherapy of small cell lung cancer (
Cancer Conference (ELCC) shows that white blood
cell boosting drugs are safe during concurrent chemo - radiotherapy of small
cell lung cancer (SC
lung cancer (
cancer (SCLC).
The modified toxin could treat asthma, in which
lung cells secrete too much mucus, and
cancers in which
cells overproduce cytokines.
They reported that YAP1 is found at high levels in
lung cancer stem
cells and binds to a protein called OCT4.
Activation of beta - arrestin - 1 causes
lung cancer cells to produce proteins associated with increased motility and invasion.
The study, published April 4 in the journal The Lancet Oncology, focused on non-small
cell lung cancer, which is the most common form of
lung cancer.
In the
Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and
lung cancer — two tumor types that often spread to the brain — many
cancer cells that enter the brain are killed by astrocytes.
In a head - to - head clinical trial comparing standard chemotherapy with the immunotherapy drug nivolumab, researchers found that people with squamous - non-small
cell lung cancer who received nivolumab lived, on average, 3.2 months longer than those receiving chemotherapy.
Further preclinical work will be needed to use the herpes - loaded stem
cells for breast,
lung and skin
cancer tumors that metastasize to the brain.
The main reason why people die of
cancer is that the
cancer cells spread to form daughter tumours, or metastases, in vital organs, such as the
lungs and liver.
A Yale
Cancer Center research team conducted a study to determine how those tumor
cells manage to grow outside the
lungs.
«These occult
lung cancer cells have found a unique way to co-opt the «brain microenvironment» and survive,» said Nguyen.
Soon after
lung cancer cells (in green) spread into the brain, extracellular matrix molecules (in red) can shield them from the hostile surroundings.
The abstract title was: Attempt to Validate Drug Repositioning for Metastatic Small
Cell Lung Cancer (SCLC) Therapy Identifies Statins Associated with Survival Benefit.?
Furthermore, they found that by inhibiting Akt they could significantly slow
cell proliferation,
cell migration and
cell invasion in the
lung cancer and bladder
cancer cells.