Sentences with phrase «cell lymphoma identified»

Not exact matches

Several years ago, NCI scientists identified the two primary subtypes of DLBCL based on characteristic patterns of gene activity within the lymphoma cells.

Professor Gandhi said results from a landmark study regarding the tool would help clinicians identify the best course of action for patients with Diffuse Large B - Cell Lymphoma (DLBCL).

«We've known about these cells blocking immune response for a decade, but haven't been able to shut them down for lack of an identified target,» said the paper's senior author, Larry Kwak, M.D., Ph.D., chair of Lymphoma / Myeloma and director of the Center for Cancer Immunology Research at The University of Texas MD Anderson Cancer Center.

His group uses genome - wide and gene - specific DNA methylation analysis to identify aberrantly silenced tumor suppressor genes in B cell leukemias and lymphomas.

Use of exon - based transcriptome profiling to identify novel signaling pathways and survival - associated genes in diffuse large B - cell lymphoma.

Thanks to proceeds from the ride, researchers have identified a subset of non-Hodgkin's lymphoma cells that resist standard chemotherapy and can cause cancer to recur.

By doing genome - wide association, we identified loci predisposing to hemangiosarcoma and B - cell lymphoma.

First observed in B - cell lymphoma, recurrent mutations of epigenetic modifier genes have recently been identified in PTCL - NOS. 9 In the present study, we performed targeted sequencing of the main epigenetic modifier genes in a large cohort of Chinese PTCL - NOS patients.

Here we screened the core set of genes related to histone methylation (KMT2D, SETD2, KMT2A, KDM6A) and acetylation (EP300, CREBBP) and identified 59 somatic mutations in 45 of 125 (36.0 %) patients with peripheral T - cell lymphomas, not otherwise specified.

Amplification of the JAK2 locus has been described in Hodgkin disease and mediastinal B - cell lymphoma, 18,19 and biallelic inactivating mutations in suppressor of cytokine signaling - 1 (SOCS - 1), a negative regulator of JAK2, have been identified in mediastinal B - cell lymphoma.20 Genomic analysis of JAK2 and of other JAK - STAT pathway members may lead to the identification of mutations of the JAK - STAT pathway in lymphoid diseases and other malignancies.

RhoH is a newly identified hematopoietic small G protein, originally cloned as one of the genes frequently disrupted in diffuse large B cell lymphoma (1, 2).

For example, we identified a predilection of certain breeds to develop lymphomas with a distinct cell of origin, and we discovered regions of the genome that are associated with cancer risk in certain dog breeds.

Project Abstract: This study extends the investigator's recently completed AKC Canine Health Foundation - funded project studying 12 dog breeds to identify major differences in the degree to which spay or neuter may be related to an increase in joint disorders (hip dysplasia; cranial cruciate ligament tear) and / or cancers (lymphoma; hemangiosarcoma; and mast cell tumor).

With this panel, we can identify, or rule out, multiple diseases inherited in Labradors, such as hip dysplasia, ruptured anterior (cranial) cruciate ligament, mast cell tumor, T and B - cell lymphoma, posterior polar cataracts, liver disease, laryngeal paralysis, degenerative myelopathy, epilepsy, tricuspid valve dysplasia and obesity.