Cells towards the edge of the colony are in intimate contact with the feeder cell layer, which produces stem
cell maintenance factors such as the BMP antagonist gremlin [21], GDF - 11, and GDF - 8 [34].
Not exact matches
Kruppel - like
factor 4 (KLF4) is required for
maintenance of breast cancer stem
cells and for
cell migration and invasion
While scientists have long known that a group of transcription
factors are needed for stem
cell maintenance, the sheer number of possible interactions among them has made the question of which are essential too complicated to address in the laboratory alone.
Determining the effect (s) of these extrinsic
factors on induced retinal
cells and the formation of the CMZ in induced eyes will help define the molecular mechanisms regulating the formation and
maintenance of retinal stem
cells and the niche in which they reside.
The aims of the CEMC are to define the step-wise molecular and cellular alterations that occur during the process of carcinogenesis; determine how environmental exposures cause key genetic mutations and epigenetic changes that underlie carcinogenesis; and discover the impact of environmental
factors on the generation and
maintenance of cancer stem
cells.
CD4 + regulatory T (Treg)
cells expressing the forkhead box transcription
factor Foxp3 have a vital function in the
maintenance of immune homeostasis and the prevention of fatal multi-organ autoimmunity throughout life.
Transcription
factor EB (TFEB): Increased activation of TFEB spurs greater autophagy and so helps to ensure better
maintenance of
cells.
A lot is known about the transcription
factors important for self - renewal and
maintenance of neural stem
cells, but drugging these is notoriously difficult.
He currently studies the
factors that promote
cell self - renewal, the
maintenance of pluripotency, and the pathways leading to the differentiation to specific
cell types.
These
factors, along with stem
cell autocrine
factors such as nodal and GDF - 3, might maintain a high local ratio of SMAD2 / 3 to SMAD1 signaling to drive stem
cell maintenance.
Through this mechanism, it would be possible for a
cell to couple extracellular cues to
maintenance of pluripotency through direct regulation of transcription
factor activity, and to fine - tune gene expression as the extracellular environment dictates.
Studies have identified transcription
factors such as Stat3, Nanog, and Oct4 as being necessary for embryonic stem (ES)
cell self - renewal and
maintenance of pluripotency.
Ketones are produced specifically by the body to feed the brain... Ketones not only supply a superior source of energy to the brain but trigger the activation of specialized proteins called brain derived neurotrophic
factors that function in brain
cell maintenance, repair, and protection.
Some of the health - giving attributes of omega - 3's include the following: regulation of inflammation, alleviation of pain, prevention of excessive blood clotting,
maintenance of the integrity of
cell membranes, reduction in elevated cholesterol and triglycerides, optimal fetal development, reduced cardiovascular risk
factors, anti-cancer properties, better cognitive function, reduced incidence of depression, among many others.
Fasting has also been shown to increase the brain - derived neurotrophic
factor (BDNF) that contributes to the growth and
maintenance of the brain's nerve
cells, and has an anti-depression effect.
The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission
maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear
cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating
factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.
Bus accidents may be caused by a number of
factors, including distracted driving,
cell phone use, operator error, speed, driver fatigue, intoxication and
maintenance violations.