Sentences with phrase «cell maintenance factors»

Cells towards the edge of the colony are in intimate contact with the feeder cell layer, which produces stem cell maintenance factors such as the BMP antagonist gremlin [21], GDF - 11, and GDF - 8 [34].

Not exact matches

Kruppel - like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

While scientists have long known that a group of transcription factors are needed for stem cell maintenance, the sheer number of possible interactions among them has made the question of which are essential too complicated to address in the laboratory alone.

Determining the effect (s) of these extrinsic factors on induced retinal cells and the formation of the CMZ in induced eyes will help define the molecular mechanisms regulating the formation and maintenance of retinal stem cells and the niche in which they reside.

The aims of the CEMC are to define the step-wise molecular and cellular alterations that occur during the process of carcinogenesis; determine how environmental exposures cause key genetic mutations and epigenetic changes that underlie carcinogenesis; and discover the impact of environmental factors on the generation and maintenance of cancer stem cells.

CD4 + regulatory T (Treg) cells expressing the forkhead box transcription factor Foxp3 have a vital function in the maintenance of immune homeostasis and the prevention of fatal multi-organ autoimmunity throughout life.

Transcription factor EB (TFEB): Increased activation of TFEB spurs greater autophagy and so helps to ensure better maintenance of cells.

A lot is known about the transcription factors important for self - renewal and maintenance of neural stem cells, but drugging these is notoriously difficult.

He currently studies the factors that promote cell self - renewal, the maintenance of pluripotency, and the pathways leading to the differentiation to specific cell types.

These factors, along with stem cell autocrine factors such as nodal and GDF - 3, might maintain a high local ratio of SMAD2 / 3 to SMAD1 signaling to drive stem cell maintenance.

Through this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dictates.

Studies have identified transcription factors such as Stat3, Nanog, and Oct4 as being necessary for embryonic stem (ES) cell self - renewal and maintenance of pluripotency.

Ketones are produced specifically by the body to feed the brain... Ketones not only supply a superior source of energy to the brain but trigger the activation of specialized proteins called brain derived neurotrophic factors that function in brain cell maintenance, repair, and protection.

Some of the health - giving attributes of omega - 3's include the following: regulation of inflammation, alleviation of pain, prevention of excessive blood clotting, maintenance of the integrity of cell membranes, reduction in elevated cholesterol and triglycerides, optimal fetal development, reduced cardiovascular risk factors, anti-cancer properties, better cognitive function, reduced incidence of depression, among many others.

Fasting has also been shown to increase the brain - derived neurotrophic factor (BDNF) that contributes to the growth and maintenance of the brain's nerve cells, and has an anti-depression effect.

The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.

Bus accidents may be caused by a number of factors, including distracted driving, cell phone use, operator error, speed, driver fatigue, intoxication and maintenance violations.