Sentences with phrase «cell maintenance signals»

Extraembryonic endoderm cells might secrete BMP and Wnt antagonists that enable neighboring cells in the center of the colony, well away from stem cell maintenance signals, to undergo anteriorization and neural commitment.

Not exact matches

«Overall, our data suggest that a novel signaling mechanism underlies the transformation of proneural glioma stem cells to mesenchymal - like cells and their maintenance as stem - like cells,» Nakano says.

These functions range from metabolism, maintenance and control of the cellular structure to the exchange of signals with other cells and the environment.

Furthermore, POSTN was reported to bind to Wnt ligands, leading to an increase in Wnt signaling in CSCs, a known regulator of stem cell maintenance in a variety of tissues (Malanchi et al., 2012).

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

Wnt / β - catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse ES cells.

Recently, tumorspheres derived from non-small cell lung cancer (NSCLC) cells showed altered DNA repair signalling possibly contributing to chemotherapy / radiotherapy resistance and subsequent maintenance of tumorigenicity [17].

And above all, mature cell therapy can be expected to restore the dopaminergic cellularity of the SN and ultimately innervation of the striatal targets, leading to recovery of DA signaling and the maintenance or regaining of motor control.

She joined Dr. Rik Derynck's lab at the University of California San Francisco, as a postdoctoral researcher to explore the mechanisms of TGF - b signaling for the maintenance of human ES / iPS cell pluripotency.

The working hypothesis of the Herlyn lab is that tumor - maintenance cells (tumor stem cells) are central to dormancy due to their non-proliferation or very slow turnover and their non-responsiveness to growth signals.

Inhibition of Notch signaling reduces proliferation of stem cells, induces cell death, and down - regulates non-canonical Wnt5a, suggesting that the Notch pathway contributes to maintenance and motility of the stem cells.

These factors, along with stem cell autocrine factors such as nodal and GDF - 3, might maintain a high local ratio of SMAD2 / 3 to SMAD1 signaling to drive stem cell maintenance.

Peerani et al. [31] suggested that there is a minimal colony size effect the maintenance of human ES cell pluripotency, and provided evidence that autocrine regulators of BMP and nodal signaling are key components of this regulatory pathway.

Development of cartilage tissue from mesenchymal stem / stromal cells after eight weeks in vivo: Inhibition of the signaling pathway of the protein BMP leads to the maintenance of stable cartilage tissue, indicated by red staining (left).

Studies show that nitric oxide signaling and the blood flow increases it stimulates play a central role in nerve cell maintenance, growth and repair.,, Most pertinent to anyone looking to enhance their aptitude for learning, nitric oxide - induced blood flow also makes forming new memories physically possible as it plays a key role in what neurologists call long - term potentiation, a process required for assembling and reinforcing new synaptic connections throughout the entire cerebral cortex, striatum, and hippocampus.

Studies show that nitric oxide signaling and the blood flow increases it stimulates play a central role in nerve cell maintenance, growth and repair.

Maintenance of mineral status; skeletal structure; muscle contraction; blood clotting; nerve conduction; cell signalling; phosphorous balance

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