Sentences with phrase «cell markers showed»

In 1988 and 1989 at Edouard Herriot Hospital, two fetuses whose blood cell markers showed they had severe immune disorders became the first ever to receive a cell transplant.

Not exact matches

In clinical trials the treatment — which involves extracting individual patients» immune T - cells, modifying them to seek out tell - tale biological markers associated with blood cancers like aggressive lymphoma, and then pumping those modified killer cells back into the body — has shown major promise, in some cases eliminating all signs of the cancer in patients six months after treatment.

Previous research shows human induced pluripotent stem cells (hiPSCs)-- generated directly from adult cells — can express markers for a wide variety of cells, including those that secrete NP.

They also showed that the cells have most of the surface «markers» considered as identifiers of embryonic stem cells and form «embryoid bodies» — characteristic clumps of cells formed by ESCs.

The results showed that, when applied, a long - term inhibition of Rho - kinase signaling increased the expressions of chondrocyte - specific genes and differentiation markers in human chondrosarcoma 2/8 cells.

The figure in question is supposed to show patterns of expression for a range of ES cell markers in the 11 cell lines.

The ability to track markers inside and outside a cell simultaneously, and to map them atop images showing the cell's shape, is also helping researchers study the metabolic effects of signaling molecules, such as G - protein - coupled receptors.

This way, Professor Henrik Zetterberg and his colleagues could show that a special nerve cell protein, called tau, at elevated levels in the blood is a marker of concussion.

Findings by Cincinnati Cancer Center researchers show that levels of bisphenol A (BPA) in men's urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cells.

Dr Mohamed Elrayess, from ADLQ, said: «In this study we have shown that the impaired ability of fat stem cells to store excess fat was partially due to increased levels of the inflammatory marker interleukin - 6 in the blood.

Examination of gene expression in patients with non-small cell lung cancer (NSCLC) showed the area adjacent to tumors is rich with cancer markers.

In a statement put on the Web this morning, NIH reported that all 64 lines «show characteristics of stem cell morphology» and have undergone several population doublings, and most of them have demonstrated all the protein markers «known to be associated with human embryonic stem cells.»

The authors believe theirs is the first study to show that mouse mammary gland tissues are sensitive to a mixture of 23 commonly used UOG chemicals, with dose - specific effects on tissue morphology, cell proliferation and induction of intraductal hyperplasias, an overgrowth of cells considered a marker for future breast cancer risk.

«We now have the first marker for the capacity of brain immune cells to remove toxic materials,» says Haass, «and its increase long before full Alzheimer's dementia shows that there is early neuronal injury that does not yet affect memory, but already triggers a microglia response.»

The Discher Lab has since shown that a protein on human cells called CD47 functions as a «marker of self» by interacting with a protein on the surface of macrophages called SIRPA.

This is the first time these cell types have been shown to be a promising marker for prostate cancer spread.

Liver cells lacking TRF1 gene (right) show, under chronic stress, larger nuclei and other markers characteristic of patients with cirrhosis or hepatitis (an increase in p21, PCNA and cyclin D1), when compared to normal cells under the same stimulus (left).

A series of genetic markers sprinkled throughout the cells» chromosomes show the same pattern found in parthenogenetic mice as opposed to cloned mice, according to a report published online today in the journal Cell Stem Cell.

CALB and L7 are Purkinje - cell specific late markers are shown.

Colonies of genetically corrected cells taken from Fanconi anemia patients show red and yellow, markers associated with pluripotency.

These cells also showed early markers that are specific to developing Purkinje cells, granule cells, or deep cerebellar projection neurons — all types of neurons only found in the cerebellum.

Using FACS we also found that all of the F4 / 80 + cells coexpressed the common leukocyte antigen CD45 and the monocyte lineage marker CD11b (data not shown).

A section of a head and neck tumor — red and green markers show the proliferation of cancer stem cells — that formed when one of several newly characterized genes, Myh9, was suppressed.

Overexpression of wild - type ACVR1 in chick micromass cultures resulted in expression levels of marker genes that are comparable to those of the empty viral vector, while cells overexpressing R206H ACVR1 showed upregulation of collagen type II and aggrecan.

In this report, we indeed showed that CSCs isolated from both 231BoM and 231BrM have strong tumor - initiating abilities; however, they preferentially metastasize to bone and brain, respectively, despite the fact that these cells were isolated using the same markers (CD24 − / CD44 + / ESA +).

Remarkably, the relative expression levels of all marker genes were only slightly decreased when R206H ACVR1 and Q207D caACVR1 cultures were cotransfected with Noggin, whereas cells expressing the wild - type ACVR1 or empty viral vector showed clear downregulation of all analyzed marker genes for chondrogenesis.

The scientists also found that a protein known as CD29 acts as a cell - surface marker for precursor fat cells that can generate mature cells with high energy potential, as shown by their UCP1 expression.

The researchers have shown that this marker protein changes myoepithelial cells in breast tissue to promote tumor cell invasion in vitro and enhances mammary tumor growth in vivo.

(D) Cryostat section (12 µm) shows cells labeled for the retinal ganglion cell (RGC) marker, hermes, by in situ hybridization.

Whilst the supplements did not affect maximal oxygen uptake or the results of a 20 metre shuttle test, the results showed that markers for the production of new muscle mitochondria — the power supply for cells — increased only in the group without supplements.

Importantly, evaluation of activation markers on peripheral CD8 + T cells showed decreased numbers of naive (CD44loCD62Lhi) T cells in splenocytes of KO mice (Fig. 2C), as has been previously observed (17), which was enhanced in DKO mice.

«We showed that there are markers on these stomach tumour cells that indicate they would be responsive to a type of immunotherapy called immune checkpoint inhibitors, in particular anti-PDL1 immunotherapy, which is already used with great success in the treatment of melanoma and certain other cancers.

By means of a non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].

Results showed that CD32 expression is rather a marker for activated, HIV infected CD4 T cells, since it was co-expressed with other molecules that characterize immune activation.

(B) High power image showing pigment granule - containing donor cells in the RPE - L region that are positive for human nuclear marker (arrows).

Moreover, the treated animals showed no signs of inflammation or cell damage in their spines, classic markers for MS.

«We've shown that there's no need to use markers to isolate successfully reprogrammed cells,» says Meissner.

Through extensive examination, we have shown that human NSC - derived iPS cells are phenotypically identical to hESCs by all pluripotential markers analyzed and for their ability to differentiate into all three major germ lineages.

«Our study shows that lipofuscin in the retina and in blood cells could serve as an early marker of disease,» said Green, medical director of the UCSF Multiple Sclerosis Center and director of the UCSF Neurodiagnostics Center.

Using this cell line we show that apparently undifferentiated ES cell cultures consist of at least three cell types defined by this lineage - specific low - level transcription and the expression of the ES cell markers Oct4 and Nanog.

I, RT - PCR from undifferentiated and EB - derived iPSCs showing expression of markers for all three primary germ cell layers.

Donor cells (hNPCctx or hNPCctx - GDNF) that migrated within the neurosensory retina did not express the retinal markers recoverin (Figure 6A), PKCα (Figure 6B), rhodopsin, parvalbumin or calbindin (latter markers not shown).

Gladstone and UCSF scientists show that lipofuscin in the retina and in blood cells could serve as an early marker of certain neurodegenerative diseases.

(A) Flow cytometry of two independent HV clones (HV 5.1 and HV 16.1) cultured either under self - renewing conditions or in the absence of LIF show the presence of a subpopulation of cells positive for Venus and / or the ES cell surface marker SSEA - 1.

Every PrEn marker present in our data set increased in the differentiated V+S − cells and importantly showed small but consistent increases when the V+S + fraction was compared to V − S + cells.

The researchers followed up to identify markers of aging in these cells, using several mouse models — one with impaired glucose tolerance (a contributor to type 2 diabetes progression) and another that shows markers of rapid aging.

Here we show that the frequency of CD8 + T cells expressing the inhibitory killer cell lectin - like receptor G1 (KLRG1), a marker of cells unable to undergo further clonal expansion, was markedly elevated in CD8 + T cells from old donors.

To amplify the germ cell marker genes, primers were designed based on the human sequences as shown in Table 1.

Venus positive cells experiencing low - level transcription at the Hex locus, but still expressing the ES cell markers SSEA - 1 and Oct4, show elevated levels of PrEn gene expression and reduced levels of early ICM markers such as Nanog.

Phenotypic characterizations reveal high levels of CD44, α2β1 integrin, and β - catenin expression in holoclones, whereas meroclones and paraclones show markedly reduced expression of these stem cell markers.