Not exact matches
The new research finds that the
stiffness of the extracellular matrix and the availability of certain ligands (molecules that bind to
cell membranes) can together determine which genes are actually called on — and whether normal epithelial
cells begin to exhibit the behaviors characteristic of highly malignant cancer
cells.
Increasing the
stiffness of cancer
cell membrane enhanced the entry of polymer nanoparticles through pathways rich in cholesterol.
The Freiburg team of Shastri, Dr. Shengnan Xiang and Dr. Melika Sarem, have now discovered that liposomes — nanoscale vesicles of lipid molecules encompassing an aqueous core — can be used to alter the
stiffness of the
cell plasma
membrane through lipid transfer.
A research team led by Prof. Dr. Prasad Shastri at the University of Freiburg has shown that the
stiffness of the cancer
cell plasma
membrane affects how nanoparticles are internalized, and this process can be enhanced when the
cell plasma
membrane stiffness is increased.
More information: Shengnan Xiang et al, Liposomal Treatment of Cancer
Cells Modulates Uptake Pathway of Polymeric Nanoparticles by Altering
Membrane Stiffness, Small (2018).
The saturated fat in butter actually enhances our immune function, protects the liver from toxins, provides nourishment for the heart in times of stress, gives
stiffness and integrity to our
cell membranes, and aids in the proper utilization of omega - 3 essential fatty acids.
Saturated fats provide the appropriate
stiffness and structure to our
cell membranes and tissues.
Since saturated fats tend to be more solid than unsaturated fats at a given temperature, they help give the
cell membrane its necessary
stiffness and integrity for proper function (23).