Microfluidic tools for precision measurements of
cell migration speed reveal that migratory speed of individual cells changes stochastically from parent cells to their descendants, while the average speed of the cell population remains constant through successive generations.
A team of researchers at the Massachusetts General Hospital and Harvard Medical School in Boston has developed technologies for precision measurement of
cell migration speed before and applied the new tool to study the variations of migration speed in population of cancer cells.
The team from the Massachusetts General Hospital plans to use the microfluidic devices in synergy with some more sophisticated molecular biology tools and identify the control factors of
cell migration speed.
Not exact matches
One interesting finding from this study was that the
speed of
migration, maintained relatively constant throughout the life of a
cell, is not inherited from the mother down to the daughter
cells.
Instead, the characteristic
migration speed of each
cell changes randomly through successive generations.
This finding comes as a surprise, considering that the average
migration speed of the larger
cell population does not change through multiple cycles.
Interestingly, each
cell that migrates through the channels maintains its
migration speed throughout its lifetime.
«Stochastic variations of
migration speed between
cells in clonal populations.»