Sentences with phrase «cell mobilization»

By saturating not only the blood but the tissue and other fluids in the body with oxygen, wounds are able to heal faster through stem - cell mobilization, bacteria are hindered, swelling and inflammation are drastically reduced and post-operative complications are mitigated.

Furthermore, the authors hope that further studies into the mechanisms of stem cell mobilization / migration and stem cell differentiation into glomerular and tubular cells could aid the development of this promising therapy.

However, the number of circulating stem cells can be significantly increased by a process called «stem cell mobilization,» which makes bountiful harvesting of stem cells easier and more productive.

The findings, reported in the November Free Radical Biology and Medicine, demonstrate that Nrf2 participates in stem cell mobilization and helps maintain the alveolar type 2 cell reparative process in injured lungs.

Another modified peptide POL6326 is in phase II clinical trial in hematopoietic stem cell mobilization in multiple myeloma [128].

Plerixafor in combination with granulocyte - colony stimulating factor (G - CSF) has been approved for hematopoietic stem cell mobilization to the peripheral blood in patients with non-Hodgkin's lymphoma and multiple myeloma [54].

Functional expression of HGF and HGF receptor / c - met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing.

Safety, Pharmacokinetics and Stem Cell Mobilization of TG - 0054 in Multiple Myeloma, Non-Hodgkin Lymphoma and Hodgkin Disease Patients.

Hematopoietic stem cell mobilization in patients with multiple myeloma, non-Hodgkin lymphoma or Hodgkin disease

Combination of endogenous neural stem cell mobilization and lithium chloride treatment for hydrocephalus following intraventricular hemorrhage.

Feasibility and Efficiency Study of Leukemic Cell Mobilization With Plerixafor Injection.

Hematopoetic stem cell mobilization in patients with Leukemia, Lymphoma and Multiple Myeloma

Not exact matches

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The redness and swelling you see around an infected cut represents the mobilization of a powerful arsenal of cells and molecules in response to injury and invading microbes.

When functioning properly, OTULIN regulates the development of new blood vessels and mobilization of cells and proteins to fight infection.

In experiments using enzyme inhibitors, the possibility that cinnamtannin B - 1 enhanced mobilization through the use of activation of enzymes such as PI3 kinase near the cell membrane was shown.

This process is called metastasis and requires a whole network of genes to regulate the transformation of cell shape and mobilization.

In donors, blocking the interaction between Del - 1 and hematopoetic stem cells could enhance the mobilization of those progenitors into the bloodstream.

«Mutations in this gene and others needed for mobilization of energy in cells may account for some cases of IBD in humans,» said Dr. Beutler, also Professor of Immunology.

«Electrical mobilization and guidance of stem cells in the brain therefore provides a potential approach to facilitate stem cell therapies for brain diseases, stroke and injuries,» Zhao said.

Indeed, inhibiting CXCR4 function systemically with the small molecule antagonist plerixafor results in the peripheral mobilization of hematopoetic stem cells, thus mitigating the potential of such therapy for long - term anti-retroviral therapy.

This has resulted in the FDA approval of the first CXCR4 antagonist, plerixafor (1) for the mobilization of hematopoietic stem cells (Figure 4)[54].

Innate Immunity Derived Factors as External Modulators of the CXCL12 - CXCR4 Axis and Their Role in Stem Cell Homing and Mobilization Mariusz Z. Ratajczak, Karol Serwin, Gabriela Schneider Theranostics 2013; 3 (1): 3 - 10.

His lab is interested in dissecting the impact of mobile DNA in the genome of stem cells, and discover mechanisms that may act to restrict LINE - 1 retrotransposon mobilization.

Condensin II subunit dCAP - D3 restricts retrotransposon mobilization in Drosophila somatic cells.

Joslin scientists are actively involved in studying the regulation of the many factors that control the storage, mobilization and utilization of excess energy in adipocytes (fat cells).

Perhaps the greatest attraction and chief benefit of intratumoral therapies is their ability to synergize with systemic checkpoint therapies and accelerate the development of a lymphoid infiltrate and perhaps secondary lymphoid structures in vivo, which in turn can result in systemic mobilization of a T - cell response: the local injection — global effect model.

Dr. Kinet's recent focus includes the role of mast cells and their receptors in inflammation, and the mechanisms and biological consequences of calcium mobilization in immune system cells.

Therefore, we conclude that FcεRI - induced activation of Syk is dependent on RhoH, which is essential for the phosphorylation of LAT and SLP - 76 adaptors as well as PLC phosphorylation and Ca2 + mobilization in mast cells.

It increases both basal metabolic rate and lipolysis, inhibits the activity of certain fat cell receptors that prevent fat mobilization, and increases the thermic effect of food (the «energy cost» of metabolizing food).

I ask because it is said to reduce inflammation and autoimmunity by reducing the growth and mobilization of neutrophils, and by reducing inflammatory proteins from B - cells macrophage inflammatory protein - 1 (MIP - 1 alpha, MIP - 1beta).

For those suffering from lead or other heavy metal poisoning, a protective diet that avoids processed foods and emphasizes the central components of a nutrient - dense and antioxidant - rich WAPF - style diet is essential (see sidebar).21 Nutritional status shapes susceptibility to lead toxicity in important ways, affecting lead's intestinal absorption; its mobilization, distribution and retention in the body; and excretion.22 Because oxidative stress is a likely mechanism explaining some of lead's toxic actions, some investigators have begun to explore whether natural antioxidants and trace minerals may help mitigate lead - induced cell damage.17 Specifically, researchers in Spain found that administration of vitamins A, B6, C and E along with zinc modulated some of the negative effects of lead exposure in rat pups, confirming the influence of nutritional factors on health outcomes following lead exposure.17 Vitamin D also should be a major component of a protective diet.

1,3 Dimethylamylamine is a sympathomimetic amine, meaning it mimics norepinephrine, which revs up the metabolic rate of muscle cells, increases fat mobilization and kicks up alertness.

These powerful emotions trigger adrenal hormone release — the physiological effects of which include activation of adipocyte lipase (resulting in mobilization of free fatty acids) and partial inhibition of protein synthesis, i.e., the plasma amino acids which are normally (readily) utilized by nonmalignant cells for protein synthesis are only partially used resulting in an increase in the availability of amino acids to meet tumor cell metabolic needs.

These metabolic alterations include the inability of normal tissues to take up blood glucose because of their decreased sensitivity or decreased responsiveness to insulin; an increased protein degradation combined with a decreased protein synthesis; finally an increased activity of the enzymes involved in degradation and mobilization of lipids in body fat cells.

In the future, ultra-accurate microchips and specialized sensors could be embedded in our phones and automatically send location and environmental data to databases for scientists to use, but for now there are still a host of ways that cell phones are helping to fight environmental ills from quick mobilization of protestors to smart apps and there will be many more to come.