Sentences with phrase «cell models»

This stem cell model of the disease gave the scientists the unprecedented ability to study rapidly aging cells in the laboratory.

And on another note, it may be possible that some cancers follow the cancer stem cell model while others do not.

The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.

In both rat and human cells modeling those in the heart, the test chemical seemed helpful.

The development offers a major technological advance in creating cell models of genetic diseases.

But until now, a biologist still needed strong programming skills to do detailed cell models at the molecular level, and even more than that, patience.

They used a newly established cell model that enables scientists to isolate cancer stem cells directly from patient tumor.

Researchers gain valuable information about the strengths and weaknesses of our immune system using mouse cell models such as used here.

Of course after making the list of candy and sweets my daughter could not wait to make this tasty plant cell model.

«I hope it will bolster and stimulate the community» to figure out how to better study the cancer stem cell model, he says.

Published in conjunction with this year's DC Auto Show, which I missed, it mentioned a new fuel cell model from Hyundai for the California market, while providing some background on a technology that looked much more like the next big thing a decade ago than it does to many, now.

Optimal control of a cancer cell model with delay.

Experimental approach: To use patient - specific induce pluripotent cell models from a (i) storage disease (NCL), (ii) aggregate prone disease (ALS) and (iii) a disease with no aggregates but hyperexcitability (ChAc) combined with state of the art live cell imaging techniques, electrophysiology and biophysical tools (PIV, laser ablation for cortex tension measurements, AFM).

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

16:18 - Dr Steve Goldman of the University of Rochester is giving the keynote address on new cell models for understanding Huntington's Disease.

The ability to conveniently characterise the glycolytic profile of in vitro cell models used in these disease areas and to determine how specific stress interventions (eg, nutrient deprivation, hypoxia, drug treatment) impact that profile is therefore of considerable interest.

In a new study, published in Current Biology this week, a research team from Uppsala University in Sweden reports new insights into the regenerative capabilities of Stentor, a single celled model organism for regeneration biology.

However, because J - Lat cells divide autonomously and possess other aberrations associated with cellular transformation, cytosine methylation was analyzed in a recently developed primary cell model of latency [43].

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

The Human Cancer Model Initiative is an international collaboration to develop the next - generation of cancer cell models as a resource for the scientific community.

Plant cells can also come in complicated shapes, such as the pointed, three - branched Arabidopsis trichomes that served as cell models in Szymanski's study.

«With this breakthrough it is possible to generate cell models with the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - Perales.

As proof - of - principle, the team showed that the liver cell models generated from iPSCs respond as expected to statin treatment.

In a new study, published in Current Biology this week, a research team from Uppsala University reports new insights into the regenerative capabilities of Stentor, a single celled model organism for regeneration biology.

The Mayo team developed the patient - derived cell models to test the compounds in.

Currently, primary hepatocytes are the most common cell model, but their utility is fundamentally constrained by the substantial variation between donors and the finite number of cells that are harvestable from each donor.

Compared to other hepatic cell models, these cells survive longer in culture, which enables a longer assay window in chronic - toxicity experiments and for metabolic disease modeling.

To test it out, the researchers studied peripheral blood samples from HIV - infected patients and several HIV latency cell models.

«Right now, I am really excited about how we can use the HD stem cell models developed in the Ellerby lab to understand the fundamental mechanisms of what causes HD in humans,» she said.

Taking advantage of this relevant cell model, we provided, by using a whole - genome transcriptional analysis, a list of DM1 specific biomarkers that could be considered as a robust DM1 signature.

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The researchers collected samples of indoor dust from 11 homes in North Carolina and tested extracts from the samples in a mouse pre-adipocyte cell model, 3T3 - L1 cells, often used to test compounds for potential effects on the accumulation of triglycerides, a type of fat.

Researchers at the University of Memphis and University of Pennsylvania report the development of robust new liver and fat cell models that report circadian clock function.

«There is no cancer drug in current use that was not first tested in a cultured cell model,» says molecular geneticist Michael Gottesman of NIH.

«We examined well - characterized cell models of HIV latency and immune cells from HIV patients who had been undergoing antiretroviral therapy and had undetectable viral loads,» Dandekar said.

In summary, less Cdh1 prevents the normal function of APC / C, which eventually inhibits the degradation of PAX3, potentially leading to unregulated cell proliferation and cancer (melanoma in skin cell models).

Anna Falk, docent at Karolinska Institutet's Department of Neuroscience, uses this technique to build cell models of the human brain.

The cancer stem cell model differs from the traditional idea that tumor growth is equal opportunity — that is, any and all cancerous cells can divide and cause the tumor to grow and spread.

The stem cell model says that tumor growth is more hierarchical, mainly driven by a subset of cells that can make new copies of themselves and give rise to the other cell types the tumor contains.

«How to grow a spine: Cell model reveals dynamic nature of segmentation clock that drives vertebrae formation.»

Research on new Ebola therapies has been limited by an inability to compare antiviral effectiveness, since cell model systems, treatment regimens and results are so varied that it is difficult to compare effectiveness amongst the compounds, and prioritize which ones are most promising to pursue.

If the work proceeds as expected, «all interactions between genes, proteins, and small molecules will be revealed, and the whole cellular network will be reconstructed,» says Igor Goryanin, who heads cell modeling at GlaxoSmithKline in Stevenage, U.K.

Therefore, it was critical to develop a human neural cell model to understand the neurodegenerative process of A-T and create a platform for testing new treatments.

«It is 10 times more ambitious and 100 times more important for mankind,» claims Hans Westerhoff, who heads the Silicon Cell modeling effort at the Free University in Amsterdam.

In a patient cell model with each of these three genes removed, ribitol 5 - phosphate was also absent, proving that the abnormal synthesis of ribitol 5 - phosphate is a cause of the condition.

Additionally, overexpression of POSTN in human mammary epithelial and breast cancer cells resulted in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression of POSTN resulted in an increase in the number and size of liver metastases (Bao et al., 2004).

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging