Sentences with phrase «cell models at»

But until now, a biologist still needed strong programming skills to do detailed cell models at the molecular level, and even more than that, patience.

If the work proceeds as expected, «all interactions between genes, proteins, and small molecules will be revealed, and the whole cellular network will be reconstructed,» says Igor Goryanin, who heads cell modeling at GlaxoSmithKline in Stevenage, U.K.

Not exact matches

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Tesla has been quite secretive about its latest generation of battery cells, the 2170 li - ion cells, which they designed for Model 3 and Panasonic is manufacturing them at Tesla's Gigafactory 1 in Nevada.

Though Tsuga did not explicitly comment on whether this was related to Tesla's newest mass market sedan, it's presumed that he was referring to automation of Model 3's 2170 li - ion battery cell and pack production at the Gigafactory.

Birch and Cobb maintain that the ecological model is more adequate than the mechanical model for explaining DNA, the cell, other biological subject matter (as well as subatomic physics), because it holds that living things behave as they do only in interaction with other things which constitute their environment (LL 83) and because «the constituent elements of the structure at each level (of an organism) operate in patterns of interconnectedness which are not mechanical» (LL 83).

The group tries to model biological behavior at the tissue, cellular and cell signaling levels.

«In theory, we could model progression of the disease by reprogramming skin cells from patients at a range of ages, including before symptoms begin.

Her interest was piqued: Upon graduating in 1999 she joined the lab of Ding Xue at the University of Colorado, Boulder, to study how cell death is regulated in the model organism Caenorhabditis elegans.

«Our research is the first to study Zika infection in a mouse model that transmits the virus in a way similar to humans,» explains Alysson R. Muotri, Ph.D., professor and director of the Stem Cell Program at UC San Diego and co-senior author of the study.

«We found that the syncytiotrophoblasts formed in our system recapitulated the barrier properties of the naturally occurring cells and they resisted infection by a model virus and three genetically different strains of Toxoplasma,» said co-investigator Jon P. Boyle, Ph.D., associate professor of biological sciences at Pitt.

Researchers at the University of Pittsburgh and Magee - Womens Research Institute (MWRI) have devised a cell - based model of the human placenta that could help explain how pathogens that cause birth defects, such as Zika virus, cross from mother to unborn child.

«We are very excited about the prospect of using these more physiologically relevant cell - based models for gene and small molecule drug discoveries,» says Dr. Andrew Liu, Assistant Professor of Biology at the University of Memphis.

Researchers at the University of Memphis and University of Pennsylvania report the development of robust new liver and fat cell models that report circadian clock function.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.

By creating an experimental model of leukemia in mice whose cancer cells were resistant to chemotherapy the team was able to caracterize these cells» metabolic profile and observed certain modifications at the level of the mitochondria.

Now, in a paper published on Oct. 3 in the Biophysical Journal, researchers at UConn Health's Virtual Cell Project have made it far easier for cell biologists to build complex biological modCell Project have made it far easier for cell biologists to build complex biological modcell biologists to build complex biological models.

The researchers have also developed an analogous model that works for calcium interactions with phospholipids at the cell membrane.

In the current study, Frank Longo, MD, PhD, and others at Stanford University, tested LM22A - 4, a drug that specifically binds to and activates the BDNF receptor TrkB on nerve cells, in mice that model the disorder.

Researchers, led by Joshua Mayourian at the Icahn School of Medicine at Mount Sinai, used mathematical modeling to simulate electrical interactions between these stem cells and heart cells to develop insight into possible adverse effects, as well as to hypothesize new methods for reducing some potential risks of this therapy.

A newly characterized group of pharmacological compounds block both the inflammation and nerve cell damage seen in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week in the journal Nature Neuroscience.

In collaboration with Prof. Dr. Roland Schüle and his team at the Center of Clinical Research of the Freiburg University Medical Center, the scientists were able to test several epigenetic inhibitors that had been newly developed by Schüle and his team on the cancer stem cell model.

«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve cell damage seen in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

The study — which looked at the action of Substance P within nerve cells in the lab and in animal models — focused on acute pain, but Professor Gamper aims to look at its role within chronic pain as well.

In a new study, Murphy, a molecular biologist at Princeton University, showed that long - lived bodily, or somatic, cells in Caenorhabditis elegans, a one - millimeter nematode commonly used as a model for aging studies in labs, activate genetic pathways completely separate from those found in long - lived egg, or oocyte, cells.

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

Researchers have proposed at least five models of Barrett's esophagus, each based on a different cell type.

«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.

Two of his math professors were collaborating with physiologist Joshua Singer, also at Northwestern, who was keen to model the biology of a retinal cell called the AII amacrine interneuron.

Still, he says, other groups have arrived at opposing results regarding the role of T cells in the disease, in part, perhaps, because their animal models aren't the same.

In collaboration with the group of Valerian Kagan, Ph.D., D.Sc., at the University of Pittsburgh, Gabrilovich and colleagues analyzed in great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surface.

Working in Morrison's Neurotrauma and Repair Laboratory at Columbia Engineering, the team developed a blast injury model using a shock tube and custom - designed sample receiver to simulate a primary blast event and applied it to an isolated, living model of the BBB that consisted of brain endothelial cells.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

«Our work could lead not only to a better understanding of the biology of the optic nerve, but also to a cell - based human model that could be used to discover drugs that stop or treat blinding conditions,» says study leader Donald Zack, M.D., Ph.D., the Guerrieri Family Professor of Ophthalmology at the Johns Hopkins University School of Medicine.

Today, a team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Partha Mitra describes a new mathematical model that combines large data sets to predict where different types of cells are located within the brain, based on their molecular identity.

The CRISPR - Cas9 technology allows researchers to transiently introduce DNA double - strand breaks into the genome of cells or model organisms at genes of choice.

When we experimentally increased the expression of the microRNAs in model nerve cells designed to replicate the conditions of HD, the cells lived longer, indicating that these miRNAs may promote cell survival,» explained lead author Richard Myers, PhD, professor of neurology at BUSM.

In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

Now, scientists at Boston University's Center for Regenerative Medicine (CReM) have announced two major findings that further our understanding of this process: the ability to grow and purify the earliest lung progenitors that emerge from human stem cells, and the ability to differentiate these cells into tiny «bronchospheres» that model cystic fibrosis.

Such cell - tracing techniques are the right approach to test the cancer stem cell model, says Sean Morrison, who studies stem cells and cancer at UTSMC and who was not involved in any of the studies.

«Using a genetic mouse model of DIPG, we found that the histone mutation turns off p16, which is a gene that acts like a break on dividing cells,» says senior author Oren J. Becher, MD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago.

At Brandeis, Seth Fraden, professor of physics, and Irv Epstein, the Henry F. Fischbach Professor of Chemistry, created rings of synthetic, cell - like structures with activating and inhibiting chemical reactions to test Turing's model.

By reprogramming skin cells into nerve cells, researchers at Karolinska Institutet are creating cell models of the human brain.

The test procedure is performed on an in vitro skin model built at Fraunhofer IGB from human skin cells in special culture dishes.

New models that factor in white blood cell count and blood pH do better, but «they require a lot of invasive testing,» says Anna Penn, a neonatologist at Lucile Packard Children's Hospital (LPCH) in Palo Alto, California.