Sentences with phrase «cell motility»

The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.

The Exocyst complex, which functions in polarized exocytosis, has been involved in regulation of cell motility.

Taken together, these results strongly suggest that the LPA2 signaling modulates T cell motility in the confined environments at least partly in an integrin - independent manner and may also act on cell adhesion to prevent over-adhesion to the substrates.

In vitro cell motility as a potential mesenchymal stem cell marker for multipotency.

Actin is a crucial molecule for cell motility throughout the body.

When mice were given daily injections of two different doses of JQ1 over a three or six - week period, there was at least a 90 per cent decrease in sperm count and a 75 per cent decrease in sperm cell motility.

Nuclear actin modulates cell motility via transcriptional regulation of adhesive and cytoskeletal genes.

Review of «In Vitro Cell Motility as a Potential Mesenchymal Stem Cell Marker for Multipotency» from Stem Cells TM by Stuart P. Atkinson

While much remains to be learned about chemotaxis and cell migration, the authors hope that future races will be a fun - spirited approach to continue investigating cell motility and chemotaxis on a large - scale, as well as to provide further insight into relevant areas of research.

Interestingly, Bos and colleagues recently reported that EGFR and its ligand were highly expressed in brain metastatic cells and knockdown of EGFR ligands significantly attenuated cell motility and invasion in vitro and in vivo.

As an example of our current studies, we have recently found that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by two kinases known as IKKβ and CK1α and consequently degraded by the proteasome via the SCFβTrCP ubiquitin ligase.

Our long - term goals are to understand cell motility, which is critical for immunological defense and wound healing, but unwanted during metastatic cancers.

These host cell proteins are the same proteins used during cell motility and phagocytosis, hence providing insight into normal cellular function.

Ninov N., Menezes - Cabral S., Prat - Rojo C., Manjón C., Weiss A., Pyrowolakis G., Affolter M., Martín - Blanco E. Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis.

(C — D) Treatment of cells with 0.3 μM flavopiridol reverses the accelerated cell motility of shLARP7 cells in the wound healing assay (C) and cell migration in the Transwell assay (D).

«We showed FER was essential for ovarian cancer cell motility and invasiveness, both in vitro and in vivo,» Tonks says.

(C - E) Analysis of T cell motility.

When mice were administered daily injections of two different doses of JQ1 over a three - or six - week period, they saw at least a 90 per cent decrease in sperm count and at least a 75 per cent decrease in sperm cell motility.

This is a hot area of biomedical research because some of the proteins that are involved in phosphorylation and control some part of cell motility (and ultimately cancer metastasis) may be amenable to chemical control — the creation of new drugs that could block their action and slow or stop cancer metastasis.

Jivko Stoyanov (Swiss Paraplegic Research, Nottwil, Switzerland) has suggested that in vitro cell motility could be used as an easy and quick method of evaluating an MSC population for its potential therapeutic efficacy, and his laboratory now report on this hypothesis in Stem Cells Translational Medicine [2].

For example, cilia are involved in cell motility, sensory perception, movement of extra-cellular fluids and determination of left - right asymmetry.

Currently, I work on three directions: (1) cell motility and the cytoskeleton, (2) modeling of physiology and diseases (such as autoimmune diabetes), and (3) swarming and aggregation behaviour in social organisms.

The data indicate that the HD mutation directly affects membrane dynamics, cell attachment and cell motility.

This is especially so since in animal models of ovarian cancer, Fan and the team demonstrated that FER's suppression reduced cancer cell motility and sharply reduced metastasis.

As an example, the current study identified and provided insight into the function of several genes, not previously known to be involved in the taste system, related to cell motility.

The team has identified that aggressively spreading cancer cells express a protein called Myosin - 10 which drives cancer cell motility.

With his vast knowledge, he recommended several topics and I soon became very interested in cell motility and axon guidance.

She previously received her PhD in 2014 from Iowa State University in Ian Schneider's Lab where she studied how extracellular mechanics regulates cancer cell motility.

Bone tissue engineering: Cell motility, vascularization, micro-nano scaffolding, and remodeling.

Actins are highly conserved globular proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Stathmin is essential for the regulation of the cell cytoskeleton, which is required for numerous cell processes including regulating the cell cycle, cytoplasmic organization, cell division and cell motility...

Since then, Dong has established his small lab as a key player among researchers interested in the assembly of the centriole, a barrel - shaped cellular structure central to the formation of cilia, antenna - like cell surface protrusions essential for cell motility and signal transduction.

Areas of research include biochemical and cellular mechanisms, muscle contractility and cell motility, the genetic control of cell growth and differentiation, and tissue damage and regeneration.