Sentences with phrase «cell mutation leaves»

Rather than soft, pliable red blood cells that travel easily through blood vessels, the sickle cell mutation leaves patients with red blood cells that can become brittle and banana - shaped.

Not exact matches

When this happens, CRISPR generates mutations in a specific region of the cell's DNA, effectively leaving a mark to log the event.

The researchers found that the tumors had lost these mutations by various means, including immune - mediated elimination of cancer cells containing these mutations, leaving behind cancer cells without the mutations, or by deleting large regions of their chromosomes in all cancer cells.

Left unchecked, such mutations would quickly add up, producing cells riddled with genetic errors — a recipe for DNA - damage linked disorders such as cancer, aging and neurodegenerative diseases.

This is contradictory to the common concept that cancer cells undergo a series of mutations in the course of tumor growth to acquire the ability to leave the primary site of the tumor and start migrating to other parts of the body.

Along with restoring structure and function to the p53 mutant protein, this drug compound has the ability to to activate a program that selectively kills cancer cells with this particular mutation while leaving normal cells undisturbed.

Left unrepaired, these DNA lesions could lead to induction of senescence, cell death or mutations, which could be responsible for the development of cancer, neurodegeneration and several other diseases.

The researchers hypothesize that in older people, many of the cell lineages in the blood have reached their maximum number of cell divisions and died off, leaving the ones that have divided more slowly and, therefore, have accumulated fewer mutations.