Sentences with phrase «cell necroptosis»
These data reveal that the tissue damage present in this SIRS model is reflected, in part, by breaks in the vasculature due to endothelial cell necroptosis and thereby predict that RIPK1 kinase inhibitors may provide clinical benefit to shock and / or sepsis patients.
https://www.jci.org/ Not exact matches
The research team also found that the action of a gene, ATG16L1, kept TNF alpha - driven inflammation from triggering the self - destruction of too many Paneth cells, by an explosive process called necroptosis.
The Max Planck researchers then showed that less necroptosis of endothelial cells and less metastasis occur in genetically modified animals in which Death Receptor 6 is disabled.
This process, known as necroptosis, enabled cancer cells to overcome an endothelial cell layer in the laboratory.
Receptor interacting protein kinase 1 (RIPK1) has important kinase - dependent and kinase - independent scaffolding functions that activate or prevent apoptosis or necroptosis in a cell context — dependent manner.
Research Interests: alcoholic liver disease; macrophages; C1q; apoptosis; fibrosis; liver disease; alcohol; Heme - oxygenase - 1; inflammation; necroptosis; high - fat diet; liver injury; fatty liver disease; complement; hepatocytes; alcoholic hepatitis; hepatic stellate cell; adiponectin; MIF; carbon tetrachloride
There, in a quest to develop targeted therapies for ovarian cancer, she began studying necroptosis, a form of programmed cell death.
Currently, she is investigating how inhibiting aldehyde dehydrogenase can kill ovarian cancer stem cells by inducing necroptosis.
Differential roles of RIPK1 and RIPK3 in TNF - induced necroptosis and chemotherapeutic agent - induced cell death
The group demonstrated that the AMPs directly act on the virus, rather than just inducing apoptosis or necroptosis of the infected cells as others were seen to do.