Sentences with phrase «cell niche»

This research provides new insights into the structure of the stem cell niche in health and after injury.

Yet, this increases the probability that the other stem cells in the root stem cell niche will die due to the cold, leading to the plant's death.

Cost - effective creation of biofunctionalised scaffolds, tailored to function as stem cell niches for expansion, transport and delivery.

To investigate the effect of chilling temperature on root development and growth, the team used the Arabidopsis root stem cell niche as an experimental model to perform in - depth studies at high spatial and temporal resolutions.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

Moreover, just as the stem cell niche plays a crucial role in the maintenance of stemness, many intra-microenvironmental connections and relationships between the microenvironment and the tumor play a crucial role in enriching the CSC subpopulation; as such, disrupting these relationships may be key to curbing their resistance to therapy.

Professor Karl Tryggvason discusses the use of biologically relevant human recombinant laminins from BioLamina that successfully recreates specific cell niches in the cell culture dish.

«These findings generally support earlier hypotheses about the stem cell niche environment,» says Vinogradov.

the role of somatic stem cells in determining tumor progression and metastatic behavior, and control of the stem cell niche by tumor microenvironment

This week's Journalstream spans stem cell research advances in the liver and the brain, as well as describes critical insights into stem cell niche formation.

Not only the root's stem - cell niche is located there, the root tip also accommodates sensors for an auxin - dependent growth of the plant based on gravitation.

They also plan to evolve the chemistry behind the materials so that it may be possible for gels to better mimic more complex cellular environments beyond the control of stiffness alone, as well as investigate how dynamic changes in matrix properties — a hallmark of the stem cell niche — can be mimicked in the laboratory.

Stems cells in our adult tissues live in very specific locations called stem cell niches.

Understanding stem cell niches is therefore important in the field of stem cell therapeutics.

In the intestinal stem cell niche, the key regulators are hormones called R - spondins and Wnts, which are frequently expressed together.

Where the concentration of WOX5 is high enough, the stem cell niche is able to maintain the pluripotent stem cells.

This balance is the secret to the life - long activity of a stem cell niche.

To maintain its stem cells, the organism generates the signals that block differentiation inside special stem cell niches.

«LEVER 3 - D is amazing, it opens new vistas for understanding the stem cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2005.

However, only the columella stem cell daughters die preferentially, and the death of these daughter cells allows maintenance of a functional stem cell niche.

This microenvironment, which stabilises and regulates stem cell activity, is called a stem cell niche.

Abd - B is essential for the positioning and function of the stem cell niche.

«I think that Del - 1 represents a major regulator of the hematopoetic stem cell niche,» said Triantafyllos Chavakis, co-senior author on the study and a professor at the Technical University of Dresden.

«Because the hematopoetic stem cell niche is so important for the creation of bone marrow and blood cells and because Del - 1 is a soluble protein and is easily manipulated, one can see that it could be a target in many potential applications,» said George Hajishengallis, the Thomas W. Evans Centennial Professor in the Department of Microbiology in Penn's School of Dental Medicine and a senior author on the work.

The research team led by Prof. Fiona Doetsch at the Biozentrum of the University of Basel has now shown that the choroid plexus is a key component of the stem cell niche, whose properties change throughout life and affect stem cell behavior.

Periostin (POSTN) was identified by microarray RNA profiling studies as a stromal factor involved in maintaining the normal stem cell niche and demonstrated to be secreted by stromal fibroblasts, but not by infiltrating tumor cells (Malanchi et al., 2012).

A new study by Reichenbach et al (2018) reports coordinated proliferation of three distinct epithelial stem cell niches and a role for glutamate transporter Slc1a3 in synchronisation of activated stem and progenitor cells.

Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche.

Characterization of functional potency and description of stem cell niches.

Upon activation following injury or repeated exercise, MuSCs leave quiescence to proliferate and then differentiate to form new muscle fibers while a sub-population exit the cell cycle to self - renew and replenish the stem cell niche.

To culture embryonic stem cells on LN521 enables easy and efficient expansion of your hESCs and iPSCs and provides a biorelevant in vitro stem cell niche.

However, some MSCs may originate in other cell niches.

«They generate their own stem cell niche.»

Germline; reprinted from Xie T., Germline stem cell niches (September 30, 2008), StemBook, ed.

Xiaoxi Wang, PhD, and Andrea Page - McCaw, PhD, are studying fruit fly ovaries, a model stem cell niche.

Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche.

49) Farin, H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K., Angers, S., Peters, P.J. Maurice, M.M. and Clevers, H. Visualization of the short - range Wnt gradient in the intestinal stem cell niche.