Sentences with phrase «cell niche by»

It is further proposed here that blockage of stem cell niches by senescent stem cells may account for some of the functional alterations observed in stem cell compartments at old age.

Not exact matches

Researchers from the Department of Biomedicine at the University of Basel have now found that the fate of adult hippocampal stem cells is not only controlled by their local niche, but also by a cell - intrinsic mechanism.

The current view proposes that stem cell differentiation is controlled by their local environment, the so - called niche.

«We suspected that HMGA1 might generate new stem cells, but we were extremely surprised that it also helps support these cells by building a niche,» Resar says.

Researchers saw that injecting the miR - 34a mimic in mice could prevent the metastasis of breast and skin cancer cells specifically to bone, mainly by disarming the metastatic niche in bone.

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors.

«We have found a way by which cytokinesis is temporarily halted and later started back up, and this phenomenon coordinates all cell players in the maturation of sperm cells in this niche,» says DiNardo.

What's more, the timing of that separation is controlled by neighboring stem cells in the niche.

The research team led by Prof. Fiona Doetsch at the Biozentrum of the University of Basel has now shown that the choroid plexus is a key component of the stem cell niche, whose properties change throughout life and affect stem cell behavior.

This Registered report describes the proposed replication plan of key experiments from «Interactions between cancer stem cells and their niche govern metastatic colonization» by Malanchi and colleagues, published in Nature in 2012 (Malanchi et al., 2012).

Periostin (POSTN) was identified by microarray RNA profiling studies as a stromal factor involved in maintaining the normal stem cell niche and demonstrated to be secreted by stromal fibroblasts, but not by infiltrating tumor cells (Malanchi et al., 2012).

The blood stem cells are located in specialized niches in the bone marrow and are surrounded by specialized niche cells.

Taken together, these results suggest that CSCs are essential for metastatic colonization and that CSCs induce stromal fibroblasts to secrete POSTN in the metastatic niche to support tumor cell outgrowth by augmenting the Wnt signaling pathway.

The data presented in this report (telomerase activity and BrdU - linked alkaline phosphatase activity staining) suggests that cells in the corneal endothelium may be renewed by stem - like cells located in a niche at the posterior limbus.

Priming of endothelial colony - forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signaling, FASEB Journal, 31 (2), 610 - 624 doi: 10.1096 / fj.201600.

The other one, the finding by the Clevers group in Utrecht that adult Lgr5 + stem cells from the intestine, grown 3D in the presence of basement membrane matrix and a defined set of niche factors, can develop into ever - expanding, genome - stable 3D organoids that resemble the structure and function of the original intestinal epithelium (13 - 16).

CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche.

These results provide the validity to the newly developed hypoxia / reoxygenation culture system for examining the regulation of CSCs in breast cancer cell lines by niche factors in the tumor microenvironment and developing differential targeting strategies to eradicate breast CSCs.

The company is utilizing regenerative cell therapy in situ approach by providing artificial niches for endogenous stem cells.

Daughters of the small intestinal stem cells, the Paneth cells, serve as crypt niche cells by providing Wnt, Notch and EGF signals (30).

Spatial reconstruction of immune niches by combining photoactivatable fluorescent reporters and single - cell RNA - seq.

In fact, «compromised niche function may lead to the selection of stem cells that no longer depend on self - renewal factors produced by its environment.

We further describe a mesenchymal sub-population with stem cell - like characteristics that gives rise to both lineages and, at the same time, acts as a principal component of the hematopoietic niche by promoting competitive repopulation following lethal irradiation.

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

Some of their goals include the unravelling of disease mechanisms by using nanomaterials to track cellular components and probe the chemical niche of the cells, the transformation of adult human cells into induced pluripotent stem cells and the delivery of drugs directly to immune and cancer cells.

Stem cells are thought to reside in a specific area of each tissue (called a «stem cell niche») where they may remain quiescent (non-dividing) for many years until they are activated by a normal need for more cells, or by disease or tissue injury.

I self published a non-fiction book for a niche market last year, which is doing reasonably well (by which I mean the net profit would have kept the cell phone on the past 6 months — assuming I had one.)

Publications ♦ Blue Light Cured Hydrogel Niches for Cell Immobilization: Evaluating Cell Physiology; Calvert, P.; Mishra, S.; 239th American Chemical Society, March 21 - 25, 2010 at San Francisco ♦ Blue Light Cured 3D Living Catalysts; Mishra, S.; Calvert, P.; Bioengineering Conference, 2009 IEEE 35th Annual Northeast, 3 - 5 April 2009, 1 - 2 ♦ Preparation of Thermosensitive Membranes by Radiation Grafting of Acrylic Acid / N - isopropyl Acrylamide Binary Mixture on PET Fabric; Gupta, B.; Mishra, S.; Calvert, P.; Radiation, Physics, and Chemistry; 77 (2008) 553 - 560 ♦ Technical Editor of annual textile journal Fiber to Finish (India), 2003 - 2004