Sentences with phrase «cell niche environment»
«These findings generally support earlier hypotheses about the stem cell niche environment,» says Vinogradov.
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The current view proposes that stem cell differentiation is controlled by their local environment, the so - called niche.
They also plan to evolve the chemistry behind the materials so that it may be possible for gels to better mimic more complex cellular environments beyond the control of stiffness alone, as well as investigate how dynamic changes in matrix properties — a hallmark of the stem cell niche — can be mimicked in the laboratory.
Engineering a megakaryocyte niche (a special environment in which stem cells live and renew) that supports the growth of hematopoietic stem cells in culture, is the next step for the researchers.
Only when they have found the right environment do the cells then drop into that niche — like the roulette ball falling into a numbered slot — and differentiate definitively.»
She will study how normal, healthy bone marrow stem cells find a niche and how niche environment regulates stem cell functions such as self - renewal and differentiation.
How do adult stem cells communicate with their local environment (i.e. niche) and how is the system coordinated to dictate stem cell function?
In fact, «compromised niche function may lead to the selection of stem cells that no longer depend on self - renewal factors produced by its environment.
Some researchers believe in a stem cell niche that provides a favorable environment for stem cells.
Researchers must thus ensure that the altered cellular environment, the damage of aging, doesn't prevent the treatments from working - that pristine cells can integrate and work well, not immediately die or decline in response to an age - damaged stem cell niche.