Sentences with phrase «cell niches for»

Cost - effective creation of biofunctionalised scaffolds, tailored to function as stem cell niches for expansion, transport and delivery.

Not exact matches

For sale is an e-commerce business in the cell phone accessories niche.

Not only the root's stem - cell niche is located there, the root tip also accommodates sensors for an auxin - dependent growth of the plant based on gravitation.

The therapeutic use of stem cells is a promising area of medicine for the decades ahead and researchers are examining why stem cells function in certain types of niches, microenvironments, and pockets of activity.

They also plan to evolve the chemistry behind the materials so that it may be possible for gels to better mimic more complex cellular environments beyond the control of stiffness alone, as well as investigate how dynamic changes in matrix properties — a hallmark of the stem cell niche — can be mimicked in the laboratory.

«Single gene encourages growth of intestinal stem cells, supporting «niche» cells, and cancer: Finding in mice could lead to new therapies for damaged organs, cancer.»

A new study shows that stable microvasculature constitutes a dormant niche for disseminated breast cancer cells, whereas a sprouting neovasculature (green points) promotes breast tumor cell growth.

These niches provide a specialised, ideal neighbourhood for stem cells.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

In addition, many niches contain different stem cell types, each necessary to produce the distinct types of cells needed for tissue renewal.

«LEVER 3 - D is amazing, it opens new vistas for understanding the stem cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell research since 2005.

Scientists think that these niches control stem cell behavior, that is «telling» the stem cell when to produce more stem cells or when to produce daughter cells that will be the workhorses for that tissue or organ.

For example, in both the blood - cell - producing and the hair - follicle niches, different stem cell types need to coordinate their individual production.

In addition, Berger's team has identified two surface proteins located on the neural stem cells and the surrounding niche glial cells that are responsible for the interactions between these cells.

Abd - B is essential for the positioning and function of the stem cell niche.

Engineering a megakaryocyte niche (a special environment in which stem cells live and renew) that supports the growth of hematopoietic stem cells in culture, is the next step for the researchers.

He is known for showing how niches of neural stem cells constantly regenerate parts of the rodent brain.

Zhao and his colleagues are also investigating whether a megakaryocyte niche can be used to help expand human hematopoietic stem cells in vitro and stem cell transplantation for patients.

«Because the hematopoetic stem cell niche is so important for the creation of bone marrow and blood cells and because Del - 1 is a soluble protein and is easily manipulated, one can see that it could be a target in many potential applications,» said George Hajishengallis, the Thomas W. Evans Centennial Professor in the Department of Microbiology in Penn's School of Dental Medicine and a senior author on the work.

«Even if a cell takes a wrong turn, it is ultimately sorted out again if its characteristics are unsuitable for the niche, or slot, it has landed in,» says Skupin.

Therefore, miR - 7 / KLF4 pathway may facilitate a reciprocal interaction of CSCs and these brain cells that generates a suitable niche for CSCs, although this hypothesis needs to be experimentally tested.

Taken together, these results suggest that CSCs are essential for metastatic colonization and that CSCs induce stromal fibroblasts to secrete POSTN in the metastatic niche to support tumor cell outgrowth by augmenting the Wnt signaling pathway.

The study reveals that the metastatic lesion in the liver is necessary for later metastasis to lung to occur, the former thus becoming a platform from which the cells prepare the subsequent lung metastatic niche to be colonized.

While it is generally accepted that MSC are mostly quiescent during postnatal life, MSCs in different niches can presumably differentiate into the specific cells of closely related niches during physiological turnover, injury or disease, as shown for other stem cell types (e.g., muscle satellite cells).

The discovery of human oRGs» self - renewing niche and remarkable generative capacity reinforces the idea that these cells may have been responsible for the expansion of the cerebral cortex in our primate ancestors, the researchers said.

«Additionally, these findings point to a promising strategy for delivering stem cells to targeted niches for their long - term maintenance and generation of functional cells through augmented stem cell competition.»

The Xie Lab demonstrated that differentiation - defective Drosophila ovarian germline stem cells (GSCs), behaving like human cancer stem cells, can out - compete normal stem cells for a position in the niche.

These results provide the validity to the newly developed hypoxia / reoxygenation culture system for examining the regulation of CSCs in breast cancer cell lines by niche factors in the tumor microenvironment and developing differential targeting strategies to eradicate breast CSCs.

Understanding the structure and signaling of the niche is important for developing stem - cell based regenerative therapies.

The company is utilizing regenerative cell therapy in situ approach by providing artificial niches for endogenous stem cells.

Stem cells numbers remain fixed because stem cells compete «neutrally» for niche space.

Memory CD4 + T cells, whose survival and expansion showed no requirements for MHC molecules at all, dampened the space - induced expansion of naive cells, showing that the two populations are not independent in their requirements for peripheral niches.

A new study demonstrates that normal and leukemic blood stem cells fight for the same niche with consequences for cancer treatment and transplantation.

His group defined a functional niche for B cells (around sinusoids in the bone marrow), identified the first two mutants that abrogate marginal zone B lymphocyte development, developed the concept of a follicular versus marginal zone B lymphoid cell - fate decision, and discovered two new defined stages of peripheral B cell development, the marginal zone precursor (MZP) B cell, and the Follicular type II B cell.

We investigate which CD4 T cell subsets serve as predominant niches for viral long - term persistence, and aim at identifying specific molecular pathways in these cells that can be targeted to reduce viral persistence.

It is further proposed here that blockage of stem cell niches by senescent stem cells may account for some of the functional alterations observed in stem cell compartments at old age.

Support to date for the existence of an hypoxic niche in marrow blood stem cells came from indirect evidence such as expression of the hypoxia protein Hif - 1 and related genes and staining with surrogate markers of hypoxia.

Some researchers believe in a stem cell niche that provides a favorable environment for stem cells.

Stem cells are thought to reside in a specific area of each tissue (called a «stem cell niche») where they may remain quiescent (non-dividing) for many years until they are activated by a normal need for more cells, or by disease or tissue injury.

For example, we have no information about how these newly - generated HPCs will compete with autologous bone marrow cells for hematopoietic niches in the recipient miFor example, we have no information about how these newly - generated HPCs will compete with autologous bone marrow cells for hematopoietic niches in the recipient mifor hematopoietic niches in the recipient mice.

For example, the 1995... Continue reading How nerve cells reach their niche.

While erythrocyte invasion is a rapid process, the brief extracellular exposure of merozoites outside of their intra-erythrocytic niche places them in direct contact with host antibodies, which contribute to naturally acquired immunity to malaria [8, 9]; therefore, merozoite cell surface and secreted proteins have long been considered attractive targets for rational vaccine development.

Dormant tumor cells in a hypoxic bone marrow niche (19) will be enriched for CSC in ER - α — positive breast cancer but depleted in ER - α — negative cancers profoundly influencing the capacity for late disease recurrence.

A direct positive feedback loop, in which the intracellular domain of activated Notch receptors binds to an enhancer in the second intron of the Notch1 gene to enhance its expression, is critical for intestinal stem cell self ‐ renewal and niche patterning.

Malkovich met with near - universal critical praise and garnered an Academy Award nomination for the neophyte feature director — as well as supporting actress Catherine Keener and writer Charlie Kaufman — though Stipe and the film itself were passed over for a Best Picture nod.Despite Single Cell's increasing prominence in the industry, Stipe continued to support C - Hundred for smaller - budgeted niche features such as writer - director Tom Gilroy's Spring Forward and McKay's coming - of - age drama Our Song, both of which were featured at the 2000 Sundance Film Festival.

Still, it would be a tough sell for a film about terrorist cells to find a niche in today's post Sept. 11 society regardless of how good the film is.

I self published a non-fiction book for a niche market last year, which is doing reasonably well (by which I mean the net profit would have kept the cell phone on the past 6 months — assuming I had one.)

The ongoing work of the research teams seek to define the interactions between the tumor cells and their microenvironment that determine which lineage predominates, and that provide a safe niche for tumor growth and progression.

Publications ♦ Blue Light Cured Hydrogel Niches for Cell Immobilization: Evaluating Cell Physiology; Calvert, P.; Mishra, S.; 239th American Chemical Society, March 21 - 25, 2010 at San Francisco

Publications ♦ Blue Light Cured Hydrogel Niches for Cell Immobilization: Evaluating Cell Physiology; Calvert, P.; Mishra, S.; 239th American Chemical Society, March 21 - 25, 2010 at San Francisco ♦ Blue Light Cured 3D Living Catalysts; Mishra, S.; Calvert, P.; Bioengineering Conference, 2009 IEEE 35th Annual Northeast, 3 - 5 April 2009, 1 - 2 ♦ Preparation of Thermosensitive Membranes by Radiation Grafting of Acrylic Acid / N - isopropyl Acrylamide Binary Mixture on PET Fabric; Gupta, B.; Mishra, S.; Calvert, P.; Radiation, Physics, and Chemistry; 77 (2008) 553 - 560 ♦ Technical Editor of annual textile journal Fiber to Finish (India), 2003 - 2004