Sentences with phrase «cell nucleosome»

Not exact matches

The researchers found that the binding of auranofin takes place through an allosteric, «action - over-a-distance» mechanism within the nucleosome, which is the component that contains the cell's packaged DNA.

In order to fit inside cells, DNA is wrapped around small protein spindles, forming strings of molecules called nucleosomes.

The team observed a relative scarcity of nucleosomes at telomeres from ASF1 - depleted cells, as one might expect once a histone chaperone is lost.

In January, a team at the University of Washington, Seattle, described in Cell a test that relies on tissue - specific differences in how DNA is packaged in structures called nucleosomes.

Our genes are packaged into cells by wrapping them around protein structures called nucleosomes.

Put simply, nucleosomes and methylation can affect transcription leading to changes in cells.

In a study published in Molecular Cell this month, Alexei V. Tulin, PhD, Associate Professor at Fox Chase Cancer Center, and colleagues reported that chemical modification of one type of histone — called H2Av — leads to substantial changes in nucleosome shape.

These nucleosomes remain a part of the chromatin throughout the cell cycle and are essential to both meiotic and mitotic cell divisions [12].

As do human cells, yeast also possesses so - called «fragile» nucleosomes.

One type, characterized by the presence of dynamic, unstable, nucleosomes, is found at highly expressed genes, such as those involved in the control of cell growth and division.

Because this region covers the entire CenHs - binding region (around 750 kb), the authors [6] postulated that CenH3 - containing and dimethyl - K9 H3 - containing nucleosomes are interspersed and that the position of these nucleosomes is dynamic, so that a population of cells may have the same DNA sequence interacting with both types of nucleosome.

Evidence of heterogeneous distribution of nucleosomes in chromatin fibers using STORM super-resolution imaging (Cosma's group, Cell, 2015).

The evidence for this comes from observing 30 nm and 120 nm wide fibres formed by DNA and nucleosomes purified from cells.

Sequencing of DNase I hypersensitive sites in (125 cell types), FAIRE analysis of reduced nucleosome crosslinking (25 cell types), and genomic DNase I footprinting (41 cell types).

Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome - wide in human tumor cells.

269/5: 00 Cell - free DNA comprises an in vivo nucleosome footprint that informs its tissue (s)- of - origin.

While somatic cells have dense and compacted clutches that contain tens of nucleosomes, clutches in pluripotent cells contain fewer and less compacted nucleosomes.

Nucleosomes pack together to form thick fibers, which condense even further during cell division (Miller & Levine, 2006).