Sentences with phrase «cell of origin»

The exact cell of origin of this tumor is unknown.

One of the key questions in stem cell and cancer biology is to understand the cellular hierarchy governing tissue development and maintenance and the cancer cell of origin.

«But it also suggested there are likely multiple cells of origin for rhabdomyosarcoma.

«These new findings not only demonstrate the importance of the cancer cell of origin in controlling breast tumor heterogeneity, but also show that the gene expression signature found in the early steps of tumor initiation is predictive of the type of tumors that will eventually develop and the clinical prognosis of women with breast cancers» comments Cédric Blanpain, the senior author of the Nature paper.

«Cell of origin affects malignancy and drug sensitivity of brain tumors.»

The approach helped to discover and nominate Lmx1A as a master regulator transcription factor of Group 4 tumors, which led to the identification of the likely Group 4 tumor cells of origin.

Research led by a St. Jude scientist has pinpointed likely cells of origin for a common childhood brain tumor, Group 4 medulloblastoma.

Now researchers at Uppsala University, together with American colleagues, have shown that one and the same cell of origin can give rise to different types of glioma.

«We saw that the same kind of more differentiated cell of origin, which has previously only been shown to give rise to oligodendroglioma, also can give rise to astrocytoma.

In a study published in Nature, researchers lead by Cédric Blanpain, MD / PhD, WELBIO investigator and Professor at the Université libre de Bruxelles, Belgium, in collaboration with Pr Wayne Phillips, Australia and Pr Christos Sotiriou, Bordet Institute, Belgium, uncovered the cellular origin of PIK3CA - induced breast tumors and demonstrated that the cancer cell of origin controls tumor heterogeneity and is associated with different breast tumors types and clinical prognosis.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

The actual cell of origin is different in each type of tumor, and does not have to be atumor stem cell.

Utilising both chondrocytes as a starting material and non-integrating mRNA technology as a reprogramming strategy, the group aimed to remove the risk of epigenetic memory of somatic cell of origin, which can affect future differentiation propensity, and reduces the risk of abnormalities being introduced during reprogramming.

Trowbridge hypothesized that analyzing open chromatin in bulk tumor cells could provide a possible improved method to identify cancer cell of origin because of the cell - type specificity of chromatin structure.

For example, we identified a predilection of certain breeds to develop lymphomas with a distinct cell of origin, and we discovered regions of the genome that are associated with cancer risk in certain dog breeds.

New research led by a St. Jude scientist has pinpointed likely cells of origin for a common childhood brain tumor, Group 4 medulloblastoma.

Now researchers at SciLifeLab have shown that one and the same cell of origin can give rise to different types of glioma.

Glioblastoma cells from patients that could be linked by the gene signature analysis with an immature origin generally showed a higher sensitivity to cancer drugs than glioblastoma cells that were associated with a more differentiated cell of origin.

This work led to identification of the likely Group 4 tumor cells of origin, and also yielded insights for other subtypes of the disease.

In the future, this model will be used to assess whether the clinical heterogeneity observed in breast cancers arises from their different cancer cell of origin.

The study suggested that microenvironmental cues dictate the cell of origin of melanoma.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

They found that depending on the cell of origin, mutations in PIK3CA and p53 induced very different types of tumors.

The identification of the cancer cell of origin has important clinical implications, as it enables doctors to detect malignancies earlier and predict tumor behavior more accurately.

«Esophageal cancer «cell of origin» identified: In mice, basal progenitor cells give rise to Barrett's esophagus, a precursor to cancer.»

The discovery of this «cell of origin» promises to accelerate the development of more precise screening tools and therapies for Barrett's esophagus and esophageal adenocarcinoma, the fastest growing form of cancer in the U.S.

The study focuses on «stemness,» defined as the potential for self - renewal and differentiation from the cell of origin, and on «stemness indices» developed during postdoctoral research conducted by Tathiane Malta as part of a project supported by FAPESP and with Houtan Noushmehr, a professor in FMRP - USP's Genetics Department, as principal investigator.

«This led us to believe that there must be another, yet - to - be-discovered, cell of origin for Barrett's esophagus.»

«Now that we know the cell of origin for Barrett's esophagus, the next step is to develop therapies that target these cells or the signaling pathways that are activated by acid reflux,» said Dr. Que.

Hatley said understanding the cell of origin will bring badly needed insights to aid diagnosis and treatment of rhabdomyosarcoma.

Most specialized cells made from other specialized cells retain some «memory» of their cell of origin, making them less than ideal for certain uses but better for others.

The different location of such rhabdomyosarcomas may depend, for example, on the cell of origin.»

«These tumors were not driven by muscle cells at all, so we decided to zero in on the biological machinery to find the cell of origin in these mouse tumors,» Hatley said.

In both test cases, CellNet showed that the engineered cells hadn't completely converted, retaining some characteristics of their cells of origin — but pointed to specific genetic tweaks that could be done in the lab to fix the problem.

Brain tumors arise in the glia, or supportive cells, of the brain and now are classified by their histology — characteristics visible via microscopy — and their cell of origin, either astrocytes or oligodendrocytes.

Researchers at Memorial Sloan - Kettering Cancer Center, together with collaborators in Germany, have developed a new method for identifying the cell of origin of intracellular and secreted proteins within multicellular environments.

«Esophageal cancer «cell of origin» identified.»

Using quantitative mass spectrometry to search for proteins that contained these stable isotope labels, researchers were able to determine the cell of origin of both intracellular and secreted proteins identified in multicellular culture.

The discovery of this «cell of origin» promises to accelerate the development of more precise screening tools and therapies for Barrett's esophagus and esophageal adenocarcinoma, the fastest growing form of cancer in the United States.

The researchers discovered that it is not the cell of origin but rather the genetic aberrations that control which tumor type is formed.

«Since the tumor types look different and have different prognoses it has been assumed that they arise from different cells of origin in the brain, but the fact is that the exact cell of origin has not been determined for any glioma.

Importantly, the findings suggest that, if Merkel cell carcinoma does arise from Merkel cell progenitors, then Atoh1 - positive Merkel cell precursors could be the cells of origin.

This indicated that the cell of origin also has a direct influence on the characteristics of human tumors,» says Uhrbom.

One feature of the tumor cells that the researchers were particularly interested in was their sensitivity to cancer drugs, and here too they found a correlation with the cell of origin.

«We discovered that several important characteristics of the cancer cells could be linked to the tumor's cell of origin.

To determine how the cell of origin affected the characteristics of glioblastoma cells, the researchers analysed how the activity of a large number of genes differed between tumors with different origins.

The tumor's cell of origin can be either an immature neural stem cell or a more differentiated glial cell.

«We show that the cell of origin is important for the malignancy and drug sensitivity of glioblastoma cells, and that the findings can also be applied to glioblastoma cells from patients.

To develop improved therapies for glioblastoma, more knowledge is needed about how the cell of origin affects the characteristics of the cancer cells.