Sentences with phrase «cell of origin of»

The exact cell of origin of this tumor is unknown.

«Knowing the cell of origin of cancer cells can provide insight into tumor subtypes and possibly diagnostic and therapeutic benefit,» says JAX Assistant Professor Jennifer Trowbridge, Ph.D., the lead author of the study published on July 11 in Nature Communications.

Using quantitative mass spectrometry to search for proteins that contained these stable isotope labels, researchers were able to determine the cell of origin of both intracellular and secreted proteins identified in multicellular culture.

The study suggested that microenvironmental cues dictate the cell of origin of melanoma.

Not exact matches

Do you know the mathematical impossibility that even one of these could randomly come into existance?Let alone all of the building blocks required for just a single simple cell to come together to form any type of living thing?There sure should be some blobs of fossilized transitions if evolution could happen.You people are real smart why don't you quit bashing Christians and quit believing the garbage you have been fed, and look up the evidence put forth by the Creation Research people.They have in fact proven creation down to a cellular level.Unlike evolution scientists who have no answers, but cleverly devised fables.Evolution is not even a very good fairy tale.Even if I didn't believe in God, Evolution is such a fools explanation of the origin of man that it takes just that to even consider it true.I understand though that you athiests will believe anything that allows you to love your sin and hatred of the one true God.

Origin of Life: Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this week.

ORIGIN OF LIFE: Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this weeOF LIFE: Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this weeof Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this weeof the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this weeof living cells — has been traced for the first time in a major hypothesis paper in Cell this week.

The two main frontiers of biological thought at present are (1) the living / non-living frontier (and included in this the tremendous problem of the origin of the «primitive» cell) and (2) the mind / life frontier.

In fact, the latest research in epigenetics, stem cells, and the developmental origins of health and disease is unlocking a whole new line of understanding of what breastmilk contains and its role in development.

For over one hundred years, scientists have debated the question of the origins of the lymphatic system — a parallel system to the blood vessels that serves as a conduit for everything from immune cells to fat molecules to cancer cells.

The fourth theme addresses the ethical, legal, social, and policy issues related to the origins and use of stem cells.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

«The puzzle of the origin of the eukaryotic cell is extremely complicated, as many pieces are still missing.

Building artificial cells will tell us much about the origins of life — and may explain how Darwinian evolution began, says Nobel laureate Jack Szostak

In the future, this model will be used to assess whether the clinical heterogeneity observed in breast cancers arises from their different cancer cell of origin.

«Researchers identify the cells at the origin of breast cancers.»

The origin of these complex cell types has long been a mystery to the scientific community, but now researchers from Uppsala University in Sweden have discovered a new group of microorganisms that represents a missing link in the evolutionary transition from simple to complex cells.

«Overall, our studies show that by using modified techniques we will be able to observe non-uniform cancer cells, regardless of their origin,» Polo - Parada said.

They found that depending on the cell of origin, mutations in PIK3CA and p53 induced very different types of tumors.

The identification of the cancer cell of origin has important clinical implications, as it enables doctors to detect malignancies earlier and predict tumor behavior more accurately.

In this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenaCell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenacell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenance.

The living world thrived long before the origin of nucleated organisms [the eukaryotic cells, which have genetic material enclosed in well - defined membranes].

Metastasis, the process that allows some cancer cells to break off from their tumor of origin and take root in a different tissue, is the most common reason people die from cancer.

To seed in the brain, a cancer cell must dislodge from its tumor of origin, enter the bloodstream, and cross densely packed blood vessels called the blood - brain barrier.

This provocative fact allowed him to argue that cell - competition genes could be linked to the origins of multicellular life and that investigating them could help scientists understand and treat cancer.

But a new study suggests that mature cells also play a key role in initiating cancer — a finding that could upend the way scientists think about the origins of the disease.

The discovery of this «cell of origin» promises to accelerate the development of more precise screening tools and therapies for Barrett's esophagus and esophageal adenocarcinoma, the fastest growing form of cancer in the U.S.

«Esophageal cancer «cell of origin» identified: In mice, basal progenitor cells give rise to Barrett's esophagus, a precursor to cancer.»

A comparison of these two cancers, published April 9 in the journal Cancer Cell, suggests that they are similar in origin, leading researchers at the University of Cambridge to believe that devils simply may be at greater risk for these kinds of diseases.

When Tomer compared the worm's cells with those in a vertebrate cerebral cortex, he found they were too similar to be of independent origin.

The study focuses on «stemness,» defined as the potential for self - renewal and differentiation from the cell of origin, and on «stemness indices» developed during postdoctoral research conducted by Tathiane Malta as part of a project supported by FAPESP and with Houtan Noushmehr, a professor in FMRP - USP's Genetics Department, as principal investigator.

«This led us to believe that there must be another, yet - to - be-discovered, cell of origin for Barrett's esophagus.»

«Scientists believe the molecules needed to make a cell's membrane, and thus for the origin of life, are all over space,» Allamandola says.

«Now that we know the cell of origin for Barrett's esophagus, the next step is to develop therapies that target these cells or the signaling pathways that are activated by acid reflux,» said Dr. Que.

The discovery of a relic inside our cells is shaking up our understanding of the origin of life — a marriage of RNA and proteins may be how it all really began

To understand the genetic shifts underlying the repeated origins of mycorrhizal lifestyles, the researchers focused on enzymes that degrade plant cell walls from 16 gene families associated with plant cell wall degradation.

Rewinding skin cells back to their origins in the womb could provide a powerful new vaccine against multiple types of cancer.

«Genetic origins of myelodysplastic syndrome discovered using stem cells.»

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

Blood formation was the first process for which scientists formulated and proved the theory that stem cells are the common origin that gives rise to various types of mature cells.

Further dissecting the MDS stem cells at the molecular level could provide insights into the origins and development of MDS and other blood cancers.

The researchers said the findings fundamentally change the understanding of G1 cell cycle regulation and the molecular origins of many associated cancers.

Cellular toxicity was unrelated to the type of «carrier» solution used in the cell cultures, the use of HES made from different origins (potato versus corn starch), or the time cells spent in culture with HES.

We suspect that in precancerous cells many of these normally dormant origins are activated inappropriately,» notes David Shore, professor in the Department of Molecular Biology of the UNIGE.

Cells appear in the Origin of Species as a word, in the description of the little hexagons in beehives.

Our current concept of the origin of the eukaryotic cell is in flux, however, and an evolutionary sequence that appears simple when conceptualized on a phylogenetic tree diagram may be far more complex and interesting in reality.

We know that the eukaryotic cell is of ancient origin, but we do not yet know the evolutionary dynamic that underlies its formation.»

Other features in eukaryotic cells — for instance, the cytoskeleton — may also be of bacterial descent, but so far the molecular record has not yielded unambiguous clues as to their origin.

That statement is misleading because the only «appropriate conditions» known to do this occur in actual living cells, and they use protein enzymes — which are not applicable to the origin of life — to do so.

Even though Hayflick's discoveries went against accepted scientific dogma — «I was the first one to show that aging had its origins inside the cell,» he now says — they ultimately sparked an explosion in the study of aging.