Several clinical trials are now investigating nitrite as a therapy for conditions such as heart attack, ruptured aneurysm, sickle
cell pain crisis and cardiac arrest.
Not exact matches
Their studies indicate that the two conditions common in sickle
cell disease, dramatically increase red blood
cells» adhesion to the lining of blood vessels walls and the debilitating
pain crises that can result.
The new findings and the fact that patients with sickle
cell disease have significant variability in their nitric oxide levels — even during a
pain crisis — likely explains why, Ikuta said.
ASH is alarmed about the opioid
crisis; however, it is concerned about potential adverse effects that policy changes could have on the administration of necessary and appropriate
pain medicine for patients with hematologic conditions such as sickle
cell disease (SCD), blood cancers, and other bleeding disorders.
The drug, called SelG1, also reduced the frequency of
pain crises in people with sickle
cell disease and reduced the number of days they spent in the hospital.
A person suffering from such a
crisis can experience
pain worse than childbirth, as red blood
cells clog up the blood vessels and cuts off some parts of the body from receiving oxygen.