Sentences with phrase «cell pathways in»

By taking out these survivor genes, the assassin molecule activates multiple death cell pathways in parallel.

Rutgers Cancer Institute Researcher Receives Grant to Explore Cell Pathway in Triple - Negative Breast Cancer News-Medical.net — November 4, 2016

Not exact matches

Still, researchers now have a far better understanding of the molecular pathways in the ear and how to regenerate hair cells and repair synaptic connections.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway - which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells - has been traced for the first time in a major hypothesis paper in Cell this week.

Origin of Life: Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this week.

ORIGIN OF LIFE: Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this week.

The stressor also activates key inflammatory pathways in peripheral blood cells and increases in levels of pro-inflammatory cytokines.

Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this week.

Recent findings from the University of Texas MD Anderson Cancer Center suggests that capsaicin, the active chemical compound that gives chile peppers their heat, may reduce and even block chronic inflammation pathways in cancer cells.

A Canadian study published this year around the same time titled «Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways» observed that coconut oil and its medium chain fatty acids (MCFAs) protect against amyloid beta (Aβ) induced neurotoxicity in primary rat cortical neurons.

Cauliflower is high in sulforaphane, a sulphur compound that has been shown to kill cancer stem cells, thereby slowing tumor growth and support liver detoxification pathways.

In his brain, nerve cells are branching out to connect with each another, forming primitive neural pathways.

This simply means exposing kids to a wide variety of tastes, smells, textures, colors, and sounds — experiences that can create more pathways between the cells in their brains.

Milk ducts found between fat cells and the glandular tissue also grow in number and size creating a complex web of pathways throughout your breast leading to your nipples.

Colostrum is characteristically high in sodium (> 30 mmol / L) and low in potassium (< 15 mmol / L) as a result of open paracellular pathways between mammary epithelial cells [14].

This pathway also could be relevant in conditions involving loss of cells that make this insulation, like multiple sclerosis.»

The observation that loss - of - function mutations in DENND5A causes epileptic encephalopathy suggests that DENND5A protein controls membrane trafficking pathways critical for normal neuronal development and strengthens the argument that protein trafficking processes in cells are critical for normal neuronal development and function.

Stomach switch The key to turning pluripotent stem cells into stomach cells was a pathway of interactions that acts as a switch between growing tissues in the intestine and in the antrum, a part of the stomach near its outlet to the small intestine.

When the stem cells were around three days old, researchers added a cocktail of proteins including Noggin, which suppresses that pathway, and timed doses of retinoic acid, a compound in vitamin A.

Dr Nachbur said faults in how the NOD2 pathway was controlled could enable the cell to continue to cause inflammation long after the bacterial threat has passed, leading to chronic inflammatory diseases.

At low doses of cocaine, the GAPDH in the nucleus will stimulate the neuron, but at higher doses it activates the cell's self - destruct pathway.

The researchers identify the cause of this increased production in inflammatory cells and find that blocking this new pathway could help safeguard the heart health of diabetic patients.

These give us important clues as to which biological pathways are involved in controlling the production, function and characteristics of blood cells.»

When the researchers did the opposite, turning on a PAK protein in a metastatic melanoma cell line, they found the cells became even more resistant to inhibitors of the MAPK pathway.

One factor keeping cells in this immature state is the PTEN gene, which suppresses a signalling pathway involved in cell growth.

Other researchers subsequently found similar pathways in mammalian cells.

In a study published in Nature Communications, the investigators report that hyperglycemic mice (or mice with type 2 diabetes) have a 24-fold higher accumulation of succinate, an intermediate metabolite, in the metabolic pathways of their bone marrow stromal cellIn a study published in Nature Communications, the investigators report that hyperglycemic mice (or mice with type 2 diabetes) have a 24-fold higher accumulation of succinate, an intermediate metabolite, in the metabolic pathways of their bone marrow stromal cellin Nature Communications, the investigators report that hyperglycemic mice (or mice with type 2 diabetes) have a 24-fold higher accumulation of succinate, an intermediate metabolite, in the metabolic pathways of their bone marrow stromal cellin the metabolic pathways of their bone marrow stromal cells.

When tested in cultured cells, the compound specifically activated chaperone - mediated autophagy without touching other pathways.

In the placenta, RDGs have been found working in pathways associated with many of the tools of invasion: immune suppression, blood vessel growth, cell proliferation, and inflammatioIn the placenta, RDGs have been found working in pathways associated with many of the tools of invasion: immune suppression, blood vessel growth, cell proliferation, and inflammatioin pathways associated with many of the tools of invasion: immune suppression, blood vessel growth, cell proliferation, and inflammation.

The findings are published alongside several papers in other Cell journals this week examining molecular pathways using The Cancer Genome Atlas (TCGA).

A study published on December 3rd in PLOS Pathogens suggests that one such strategy blocking the PD - 1 / PD - L1 pathway works, but only when the overall HIV load is low and regulatory T cells cooperate.

While the PD - 1 protein pathway has long been implicated as a primary player in T cell exhaustion, a major question has been whether PD - 1 actually directly causes exhaustion.

«While transient disruption of this pathway may have therapeutic benefit because it temporarily «revs up» the immune response, permanent loss of PD - 1 signals seems to result in a «flame out» where T cells can't sustain higher level activation and become more dysfunctional,» Wherry says.

Some scientists study cells, called primary human trophoblasts, that are isolated from placentas obtained after childbirth, but such cells do not divide, can be more difficult to obtain, and are more difficult to genetically manipulate to learn about biochemical pathways that have a role in placental function, Dr. Coyne said.

«Imagine if we could create circuits that detect defects in cancer cells and then turn on pathways that lead to the death of those cells,» he says.

The team found that connective - tissue cells adjacent to colon cancer stem cells secrete growth factors that activate a molecular pathway in other cells that is vital to maintaining stem - cell - like qualities.

Working in Berkeley, Lundblad discovered that even without telomerase, yeast cells can sustain their chromosome tips — the first example of an alternative telomere - lengthening pathway.

Hormones regulate a lifelong reshaping of our neuronal pathways, programming a turnover and pruning of brain cells — a process that begins in the womb and continues to affect our intellectual, emotional and social development in adulthood.

There will certainly be more: In a paper published in Cell this week, scientists at the Scripps Research Institute in Jupiter, Florida, have rigorously demonstrated for the first time in mice that the more biased a compound is toward activating the pain - relieving pathway, the less it suppresses breathinIn a paper published in Cell this week, scientists at the Scripps Research Institute in Jupiter, Florida, have rigorously demonstrated for the first time in mice that the more biased a compound is toward activating the pain - relieving pathway, the less it suppresses breathinin Cell this week, scientists at the Scripps Research Institute in Jupiter, Florida, have rigorously demonstrated for the first time in mice that the more biased a compound is toward activating the pain - relieving pathway, the less it suppresses breathinin Jupiter, Florida, have rigorously demonstrated for the first time in mice that the more biased a compound is toward activating the pain - relieving pathway, the less it suppresses breathinin mice that the more biased a compound is toward activating the pain - relieving pathway, the less it suppresses breathing.

After exploring the molecular pathway in mice, the researchers focused on cardiac stem cells in patients with heart disease.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researcherIn addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researcherin cancers, according to the researchers.

Schwarz and her colleagues used three different drugs, alone and in combination, to deprive cervical tumors of glucose and block downstream metabolic pathways that help protect cancer cells from building up toxic free radicals.

Liu acknowledged that study does not explain why disruption of the CLOCK pathway reduces the inhibitory current within the cells after it arrives via their connections, or «synapses,» with other neurons in their circuits.

Researchers filled in other details about the selective role of LKB1 in regulatory T cells, including that the molecule unexpectedly works through the Wnt signaling pathway to adjust regulatory T cell function.

Deletion of LKB1 in regulatory T cells disrupted metabolic pathways that support the health and function of the mitochondria.

We'll want to look at those pathways to understand what's going on in these iPS cells and see if we can repair them.»

The group is now pursuing studies that couple the mechanical forces of a blast, or pressure wave, to the activation of chemical - signaling pathways in neural cells.

The protein's role in the pathway leading to memory impairment, however, remained unclear until scientists from IMCB utilised live - cell imaging techniques to elucidate the mechanism of memory impairment and illustrated how SNX27 attributes to synaptic dysfunction.