Sentences with phrase «cell pathways involved»

Not exact matches

This pathway also could be relevant in conditions involving loss of cells that make this insulation, like multiple sclerosis.»

These give us important clues as to which biological pathways are involved in controlling the production, function and characteristics of blood cells.»

One factor keeping cells in this immature state is the PTEN gene, which suppresses a signalling pathway involved in cell growth.

«The pathway mainly involves signalling via the brains» immune cells, and thus differs from how today's drugs operate.

The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.

«Cardiac stem cells from heart disease patients may be harmful: Researchers discover molecular pathway involved in toxic interaction between host cells and immune system.»

The olfactory system comprises six million to 10 million receptor cells (of which there are nearly 400 different types) and links to multiple brain structures and neural pathways, including those involved in memory, emotion and movement.

They found numerous genes activated in the XYL regulon - controlled yeast that upregulated pathways involved in growth, such as cell wall maintenance, cell division, mitochondrial biogenesis and adenosine triphosphate (ATP) production.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

First, it would necessarily involve denying cancerous cells access to some tool that is absolutely indispensable to their survival, so that they couldn't just make up for its loss by tweaking some other gene expression pathway through mutating its other genes.

Previous research by Lee's lab had shown that p75 is involved in a signaling pathway that regulates the development of sensory neurons — cells which transmit our sensation of pain, touch and muscle tension — in the dorsal root ganglia.

«The iPS cells may also help us identify treatments for more common diseases, such as atherosclerosis and vascular calcification, because the same bone morphogenetic protein pathways are involved in these medical conditions.»

This animation guides us through the immune pathways involved in the disease, from the first signs of self - reactive immune cells to joint damage and other symptoms.This article was reproduced with permission and was first published on January 25, 2016.

Further investigation, says Resar, showed that these unusual properties arise from the ability of HMGA1 to turn on several genes involved in the Wnt pathway, a network of proteins necessary for embryonic development and stem cell activity.

Some data suggest that the mechanisms for each CHI3L1 function - cell protection and tissue repair - involve different pathways and or receptors.

While previous research indicated that the cellular mechanism behind the cell death involved the mitochondria and lysosomes, how these two pathways converge in dopamine neurons to cause cell death remained unknown up until now.

By identifying novel genes and molecular pathways involved in shaping a taste cell's function, these findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine - tune a person's taste perception to encourage healthier eating.

«We know that the pathway is important for normal cells to carry their activities as it is involved in regulating metabolism, that is, how cells process nutrients to obtain energy and how cells use energy to grow.

Previous experiments have enabled them to decode a signalling pathway involved in adipose cell maturation and to show that calories in the nutrient medium influence this process.

Jagged1 plays a key role in a cell signaling pathway involved in many body systems, but it was not previously known to affect Duchenne muscular dystrophy.

Which pathway the cell follows, and which genes are involved then largely determine the characteristics of a pancreatic tumor.

«We found another pathway that is dysregulated, that involves the same molecule implicated before — mGluR5 — but in an entirely different way,» said Vitaly Klyachko, PhD, an associate professor of cell biology and physiology and the study's senior author.

The KRAS oncogene activates the PI3K enzyme pathway (involved in cell growth, proliferation and survival) and the MEK / MAPK pathway (a process that governs the way growth factors bind to the cell surface).

«In this case, the pathway involved the loss of a protein called MBD3 that allows tumor cells to become more like stem cells and persist,» said first author on the study Rakesh Verma, a postdoctoral associate in hematology.

«In addition to known disease - related genes, we have discovered seven novel genes as the cause of X-linked intellectual disability and analysed what signaling pathways in the cells each protein is involved in,» says Kalscheuer.

«Although we demonstrated that BCG educates stem cells to generate trained immunity, we had no idea about the molecular mechanisms that were involved in this protective pathway,» says Dr. Divangahi, who is also an Associate Director of the Translational Research in Respiratory Diseases Program at the RI - MUHC and an Associate Professor of Medicine at McGill University.

Loss of the PBRM1 gene function caused the cancer cells to have increased expression of other genes, including gene pathway known as IL6 / JAK - STAT 3, which are involved in immune system stimulation.

Another surprising finding was the direct link between Notch and genes involved in other B cell signaling pathways.

The researchers found that overproducing the microRNAs in cultured cells cut down the concentration of E2F1, a protein involved in a cancer growth pathway, suggesting that, in healthy cells, the microRNAs keep cell growth in check.

However, her research group has not yet identified how to make stem cells yield entirely dI1 or entirely dI3 cells — perhaps because another signaling pathway is involved, she said.

Wolfson and co-first author Lynne Chantranupong, both of whom were involved in the earlier Sestrin research, found that in the absence of amino acids, Sestrin2 interacts with a protein complex known as GATOR2 to inhibit the mTORC1 pathway, thereby reducing cell growth.

Mammalian cells treated with Mcf1 also display key features of apoptosis which is putatively mediated by a BH3 - like domain and involves the mitochondrial pathway [24], [25].

The effects of mutations and other genetic changes in cancer cells play out in the complex networks of molecular interactions or «signaling pathways» involved in cell growth, proliferation, and other hallmarks of cancer biology.

Their results turned up an unexpected commonality: Early on in each of the diseases, genes involved in the same specific pathway of cell death appeared to be activated.

«But we have to further study the functions of this histone, identify the other proteins with which it is associated, and determine the enzymes that modify it and why and the cell signalling pathways involved,» explain the scientists.

The arabinogalactan sugar chain is commonly present in the cell wall of plants and is known to be involved in various signaling pathways within the cell.

«I believe that the result of this collaboration not only sheds light on the long sought mystery of arabinogalactan sugar chains but will also advance the understanding of the yet to be resolved signaling pathway between cells involving sugar chains.»

Recent advances in our basic knowledge of the pathways involved in tissue damage and regeneration have combined with remarkable progress in adult stem cell biology to put us at a genuine inflection point in the history of medicine.

The «active cell map» is the set of all interactions, complexes and pathways involving molecules in the cell and their activity under normal and diseased regulatory circumstances.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.

Research in the lab of Edward P. Feener, Ph.D., Investigator in the Section on Vascular Cell Biology and Director of the Proteomics Core at Joslin Diabetes Center and an Associate Professor of Medicine at Harvard Medical School, now has shown that a substantial percentage of patients with DME do not have high levels of VEGF in the fluid inside their eyes but do have high levels of a protein called PKal (plasma kallikrein) and associated molecules that are key players in an inflammatory molecular pathway involved in the disease.

In addition to causing proteins to be secreted through general pathways from the cell and pathways involving metalloproteases, PMA specifically causes activation of an epidermal growth factor receptor (EGFR).

To better understand how insulin signaling affects beta - cell growth, the Joslin scientists next studied a pathway involving a protein called FOXM1.

Signaling pathways involve molecules in a cell that control cell functions — like cell division — by cooperation.

Peggy Farnham is honored for her leadership and pioneering work analyzing transcriptional elements involved in regulation of cell - signaling pathways.

They describe current attempts to isolate the totipotent cells found in stem cell cultures, which involve manipulating gene networks or intercellular signaling pathways.

The genes identified by this study may implicate pathways involved in inflammation, movement of proteins within cells, and lipid transport as being important in the disease process.

Distinct c - Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1.

The Morris lab is specifically interested in utilizing the recently described endogenous non-coding RNA pathway in human cells to epigenetically modulate gene expression in those genes involved in HIV, cystic fibrosis, and cancer.

Topics covered will include how the immune system and commensal microbes interact in the context of health and disease; how dendritic cells respond to infectious or inflammatory stimuli and the roles they play in the induction and polarization of adaptive immune responses against pathogens; how the innate immune pathways regulate inflammation at mucosal barrier tissue sites and how the macrophages are involved in intestinal inflammation.