Sentences with phrase «cell phenotype in»

Effects of conjugated linoleic acid isomers on monocyte, macrophage and foam cell phenotype in atherosclerosis.

Titles: 1) Notch - 1 induces Epithelial - mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

Notch - 1 induces Epithelial - mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

1) Notch - 1 induces epithelial — mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells:

Neonatal Inhibition of DNA Methylation Alters Cell Phenotype in Sexually Dimorphic Regions of the Mouse Brain Endocrinology April 7, 2017 Morgan Mosley, Jill Weathington, Laura R. Cortes, Emily Bruggeman, Alexandra Castillo - Ruiz, Bingzhong Xue, and Nancy G. Forger Many of the best - studied neural sex differences relate to differences in cell number and are due to the hormonal control of developmental cell death.

High CD44 coupled with low CD24 expression is indicative of stem cell phenotype in clonospheres.

Further, consistent with T cell phenotypes in nontumor - bearing mice (Fig. 2), we observed an increased percentage of spleen - derived CD8 + T cells expressing high levels of the activation marker CD44 in DGKζ − / − or DKO mice that had been inoculated with tumor when compared with Cbl - b − / − or WT mice (Fig. 4C).

Not exact matches

Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.

Much of the research on CD8 + T cells has focused on studying them in the circulating blood, which has a dominant phenotype of CD8αβ +.

«Fat cells can adopt a range of metabolic phenotypes, depending on physiological conditions and location in the body,» said James G. Granneman, Ph.D., a researcher involved in the work from the Center for Integrative Metabolic and Endocrine Research at the Wayne State University School of Medicine in Detroit, MI.

«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.

Our work suggests that targeting a specific stem cell phenotype, for example with immunotherapies, could be beneficial in patients with oligodendroglioma.»

«If you see consistent phenotypes in different models, the things that are happening are probably important,» says Guo - li Ming of Johns Hopkins University School of Medicine in Baltimore, Maryland, who led the earlier studies of Zika in human neural progenitor cells.

Different abnormalities such as cleft palates, small skulls, and problems with higher brain function were seen depending on which cell types lacked Smc3 expression, but the phenotypes were similar to those seen in CdLS patients.

Seahorse XF test kits and reagents simplify cellular bioenergetics by providing precalibrated, pretested reagents for metabolic phenotyping, mitochondrial respiration, glycolysis, and fatty - acid oxidation in cells.

The researchers are now planning to address the impact of targeting autophagy either clinically and pharmacologically on the immune landscape of melanomas by phenotyping other immune cells in the melanoma tumor microenvironment.

The tool will enable better phenotyping of cell shapes and also understanding of how cell shapes change in relation to others, and over time.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

«There are several diseases, like certain types of cancer and asthma, where stiffness of the cell is known to be linked to the phenotype of the disease,» says Ming Guo, the Brit and Alex d'Arbeloff Career Development Assistant Professor in MIT's Department of Mechanical Engineering.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the other by changes in epithelial cells.

«As long as we have a way to detect and select a desired phenotype in the test cells, this method lets us fish out the antibodies that can make the phenotype happen.»

But these individuals can have a range of phenotypes, i.e. look and behave differently, due to random processes in the cells that influence how the genetic instructions are used.

In this context, phenotypes are events that happen in a cell or system before the toxicity or full - blown disease is recognized at the clinical leveIn this context, phenotypes are events that happen in a cell or system before the toxicity or full - blown disease is recognized at the clinical levein a cell or system before the toxicity or full - blown disease is recognized at the clinical level.

In the current study, the researchers looked at how a protein complex in the cell envelope, which surrounds the cell, contributes to this heterogeneity or diversity of phenotypeIn the current study, the researchers looked at how a protein complex in the cell envelope, which surrounds the cell, contributes to this heterogeneity or diversity of phenotypein the cell envelope, which surrounds the cell, contributes to this heterogeneity or diversity of phenotypes.

«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»

In stark contrast to contemporary human influenza H1N1 viruses, the 1918 pandemic virus had the ability to replicate in the absence of trypsin, caused death in mice and embryonated chicken eggs, and displayed a high - growth phenotype in human bronchial epithelial cellIn stark contrast to contemporary human influenza H1N1 viruses, the 1918 pandemic virus had the ability to replicate in the absence of trypsin, caused death in mice and embryonated chicken eggs, and displayed a high - growth phenotype in human bronchial epithelial cellin the absence of trypsin, caused death in mice and embryonated chicken eggs, and displayed a high - growth phenotype in human bronchial epithelial cellin mice and embryonated chicken eggs, and displayed a high - growth phenotype in human bronchial epithelial cellin human bronchial epithelial cells.

They are responsible for adding sugar molecules to numerous different types of proteins, whether it's a cell wall, or it's a small signaling peptide, which is what's responsible for the phenotypes in tomato.»

Those data were then combined with information about functional changes in cell behavior to develop a nanomechanical profile, or phenotype, for specific cellular states.

In the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation of the osteoblastic or osteolytic phenotype.

Rho - kinase inhibitor Y - 27632 and hypoxia synergistically enhance chondrocytic phenotype and change the S100 protein profile in human chondrosarcoma cells

In this study, researchers identified one microRNA (MIR548K) encoded in this region, and found it was characterized as a novel oncogene and functional assays which demonstrated that MIR548K enhances malignant phenotypes of ESCC cellIn this study, researchers identified one microRNA (MIR548K) encoded in this region, and found it was characterized as a novel oncogene and functional assays which demonstrated that MIR548K enhances malignant phenotypes of ESCC cellin this region, and found it was characterized as a novel oncogene and functional assays which demonstrated that MIR548K enhances malignant phenotypes of ESCC cells.

If interactions between IL - 15 and IL - 15Rα were to occur strictly as a secreted cytokine binding to a cell surface receptor, then similar exercise and muscle phenotypes would have been observed in both IL - 15Rα — KO mice and IL - 15 — KO mice, since ligand - receptor binding would have been interrupted in both of these mouse strains.

Cells isolated from lungs of infected animals exhibited relatively stable aneuploid phenotypes and were found to retain their aneuploid chromosome in 70 — 80 % of isolates based on multiplex PCR [20 isolates were analyzed from each strain, 15 were aneuploid for MN35 (75 %), 16 for MN55 (80 %), 14 for MN77 (70 %), and 15 for MN89 (75 %)(Figure S9)-RSB-.

The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist for years in secondary lymphoid organs and can differentiate into effector memory CD4 + T cells [45].

This series addresses the contribution of cellular senescence to cardiovascular, neurodegenerative, and arthritic disorders as well as the senescent phenotypes in various tissues and cell types.

Thus, our results strongly suggest that substantial loss of β cells is the likely cause of the diabetic phenotype in the animals treated with IAPP aggregate - containing materials.

Wild - type ACVR1 mRNA (6 — 60 pg) at the 1 - cell stage fully (as in A) or partially rescued the mutant phenotype (C1 dorsalized; C).

The resulting endothelial cell lines described in this study retain their phenotype after repeated passage, require minimal nutritional support and, importantly, may be useful for identifying factors that regulate endothelial cell proliferation and tumor cell adhesion in different anatomical regions.

Thus, Rho - kinase inhibition at low oxygen tension can be regarded as a potential way to enhance extracellular matrix production and maintain a chondrocyte phenotype in cell - based tissue engineering applications.

Indeed, we found that in cell lines maintained at the nonpermissive temperature (37 °C) for two to three additional passages, cells began to assume characteristics associated with a senescent phenotype (formation of giant cells, absence of cell division).

Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection.

Taken together, these data are consistent with interallelic complementation of UV sensitivity in cells but underscore the lack of any correlation between UV - related repair characteristics and TTD progeroid phenotypes in animal models.

In this study, we investigated how RASSF1A inactivation conferred invasive phenotypes to human bronchial cells.

Most of these cells are epithelial in phenotype.

Such cell lines are now opening the opportunity to carry out «large scale» functional genomics screens in order to identify the genes able to revert the mutant phenotype of the cells.

Signals from pathogens, tissue factors, and other immune cells are involved in defining the immune phenotype of these cell types.

We recently reported that CD8 (+) T cells responding to innate - like IL - 12 + IL - 18 stimulation and co-expressing the transcription factor Eomesodermin (Eomes) and KIR / NKG2A membrane receptors with a memory / EMRA phenotype may represent a new, functionally distinct innate T cell subset in humans.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

Here, Anna presents how studies of neural stem cells and neurons derived from iPS cells of patients show faithful mimicking of known disease phenotypes in our cellular models of disease, like Alzheimer's disease, autism, and Down syndrome.