Sentences with phrase «cell population derived»

However, here, we used a well - defined hematopoietic cell population derived from ES cells, and we showed the kinetics of their MHC expression.

AST - OPC1, an oligodendrocyte progenitor cell population derived from human embryonic stem cells, has been shown in preclinical testing in animals and in vitro to have three potentially reparative functions that address the complex pathologies observed in demyelination disorders, such as spinal cord injuries, and multiple neurodegenerative diseases, including multiple sclerosis and white matter stroke.

Indeed, we have obtained a homogenous mesodermal cell populations derived from human pluripotent stem cells (hES and iPS cells), which could represent discreet differentiation steps.

Not exact matches

For that, they quantified how 85 nanoparticles delivered DNA barcodes to eight cell populations in the spleen, and found that cell types derived from myeloid progenitors tended to be targeted by similar nanoparticles.

«For the broad application of stem cell - derived pituitary cells in the future, cell replacement therapy may need to be customized to the specific needs of a given patient population,» Zimmer says.

Preadipocyte populations are thought to be derived from resident mesenchymal cells.

To devise a potential new therapy, the investigators engineered a population of bone marrow derived mesenchymal stem cells loaded with oncolytic herpes simplex virus (oHSV), which specifically kills dividing cancer cells while sparing normal cells.

But, it was known that when HIF - 1 normally activates signals in the body to build new vessels, one of the many types of cells recruited to the site of new vessel growth is a population of stem cells from the bone marrow, which are called bone marrow - derived angiogenic cells.

After this period of induction, keratinocytes derived from pluripotent stem cells were isolated and amplified to obtain a homogenous and pure population of keratinocytes presenting all the phenotypic characteristic of adult keratinocytes.

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

Homogenous and functional population of keratinocytes and melanocytes derived from pluripotent stem cells were generated by designing a multi-step sequential protocol respecting the chronobiology of epidermis formation during human ontogenesis.

Functional and phenotypic differences of pure populations of stem cell - derived astrocytes and neuronal precursor cells.

Enriched population of PNS neurons derived from human embryonic stem cells as a platform for studying peripheral neuropathies.

Analysis of in vitro secretion profiles from adipose - derived cell populations.

Intriguingly, these cells, which resemble perivascular macrophages or so - called «Mato Cells» in mammals, appear to emerge by transdifferentiation from endothelium of the optic choroidal vascular plexus, and as such would represent the first described perivascular cell population in the brain derived from vascular endothecells, which resemble perivascular macrophages or so - called «Mato Cells» in mammals, appear to emerge by transdifferentiation from endothelium of the optic choroidal vascular plexus, and as such would represent the first described perivascular cell population in the brain derived from vascular endotheCells» in mammals, appear to emerge by transdifferentiation from endothelium of the optic choroidal vascular plexus, and as such would represent the first described perivascular cell population in the brain derived from vascular endothelium.

At least three replications (n = 3) were performed to derive the average percentage of each cell population in each cell line and standard deviations among the replicates.

At least three replications were performed to derive the average percentage of each cell population in each cell line and standard deviations.

At least three replications were performed to derive the average percentage of each cell population in each cell line and standard deviations among the replicates.

Excitingly, a single dose of any of the three NK cell populations assessed led to a significant reduction in tumor burden, although the iPSC ‐ derived NK group demonstrating a trend toward overall better activity.

Working in dystrophic mice while searching for a cure for Duchenne muscular dystrophy (DMD), Dr. Huard's laboratory team first identified a unique population of muscle - derived stem cells with the ability to repair muscle 8 years ago.

Yet, our knowledge about the regulation of the genome is generally based on datasets derived from large cell populations that provide an ensemble average interpretation of the biological system and disregard existing cell - to - cell heterogeneity.

Shier LR, Schultz KR, Imren S, Regan J, Issekutz A, Sadek I, Gilman A, Panzarella T, Eaves CJ, Couban S. Differential Effects of G - CSF on Marrow and Blood - Derived Hematopoietic and Immune Cell Populations in Healthy Human Donors.

In 2016, Dmitry I. Gabrilovich, M.D., Ph.D., program leader of Wistar's Translational Tumor Immunology program, and his research team identified a marker for myeloid - derived suppressor cells (MDSCs), a population of immune cells implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotherapy.

His career success began in 2006 at Celgene Corporation, where he was the principal investigator behind a highly interdisciplinary program focused on mass spectrometry - based proteomic studies of placenta - derived populations of stem cells and natural killer cells.