Sentences with phrase «cell population within»

Last week, a group of researchers from the United States and Japan published work extending our understanding of the mechanism by which a resident stem cell population within the mouse digit tip nail bed can be activated to induce digit tip regeneration.

The experimental plan includes a fine - grained analysis of the different cell populations within these precious tissues using cutting - edge single - cell genomics methods.

The laboratory currently pursues four integrated research objectives: 1) Defining how dynamic regulation of adhesion and migration controls metastasis, 2) Identification and characterization of the metastatic cell populations within a primary tumor, 3) Experimental modeling of metastasis in a clinically relevant manner, and 4) clinical implementation of molecular markers of migration as biomarkers of tumor progression and metastasis.

Not exact matches

Sampling was conducted via a stratified dual frame probability sample of landline and cell phone telephone numbers (both from Survey Sampling International) from within New York State weighted to reflect known population patterns.

Sampling was conducted via a stratified dual frame probability sample provided by Survey Sampling International of landline and cell phone telephone numbers from within New York State weighted to reflect known population patterns.

The study, «Spectrophotometric analysis at the single - cell level: elucidating dispersity within melanic immortalized cell populations,» was supported in part by the Mizzou Advantage program, an initiative that fosters interdisciplinary collaboration among faculty, staff, students and external partners to solve real - world problems in four areas of strength identified at the University of Missouri, including Food for the Future, One Health / One Medicine, Sustainable Energy and Media of the Future.

Previous studies have examined cancer stem cells (CSCs)-- small populations of cells within a tumor that are resistant to chemotherapy.

Subsequent tests revealed that the treatment had reduced the visible cell population by a factor of 100 thousand, compared with an untreated cell culture, within the space of just 20 days.

«This strategy allows a colony to hedge its bets by enabling individual cells within a population to assume high levels of resistance while others avoid this extra work.»

Within a single tumor exists such an astonishingly varied population of cells, each with its own combination of normal and abnormal genes, that at least some cells nearly always have a way to survive any particular attack.

Dr Ignacio Vazquez - Garcia, the first author from the Wellcome Trust Sanger Institute and University of Cambridge, said: «We found that the degree of diversity within the cell population — known as clonal heterogeneity — played a major role in the acquisition of antimicrobial resistance.

Stem cell populations reside in areas called niches deep within different types of organs.

Within every hair follicle is a population of melanocyte stem cells.

Lepidoptera genetics is notorious for the fact that chromosome counts can vary between populations of the same species and occasionally even within cells from the same individual, he explains.

The classical concepts of angiogenesis consider the endothelial cells within tumors as a rather passive cell population that merely reacts in response to growth factors released by the tumor cells.

He said that genetic and morphological heterogeneity within populations of animal cells is an emerging phenomenon and has been observed in tumor populations.

The majority of cell lines growing at the permissive temperature (33 °C) underwent an initial population doubling within 48 h.

These differences between cells with high and low modulations may support the idea that there are two populations of neurons within LIP [22], each of which contributes to timing differently.

Within five to nine days we can generate virtually all the pure cell populations that we need.»

The ability to make pure populations of these cells within days rather than the weeks or months previously required is a key step toward clinically useful regenerative medicine — potentially allowing researchers to generate new beating heart cells to repair damage after a heart attack or to create cartilage or bone to reinvigorate creaky joints or heal from trauma.

In previous research, he and his collaborators found that E. coli (bacteria) and budding yeast (eukaryote) use the same cellular mechanisms to ensure uniform cell sizes within a population.

While embryonic stem cells are widely studied, a lesser known, but still significant, population of stem cells also resides within the early developing embryo: trophoblast stem cells (TSCs).

A mechano - chemical feedback underlies co-existence of qualitatively distinct cell polarity patterns within diverse cell populations.

Cancer, the uncontrolled growth and migration of a small population of cells within a given tissue, is one of the leading causes of death in the United States in older adults.

With Dr. Bill Carlezon, Dr. McCullough is investigating the cell - type specific contributions of neuron populations within the nucleus accumbens to stress related pathologies.

High contrast images facilitate robust automatic tracking and behavioural analysis of hundreds of individual cells within heterogeneous cell populations is now possible without the need for intrusive dyes or labels, bringing unique morphological, temporal, and dynamic phenotypic data to your research.

They are the only means to target and manipulate specific cell types (populations) within neuronal networks in living animals.

In fact, 88 % of the barcodes within the resistant populations were shared by at least one other replicate; prior to treatment, there are small (previously undetectable) populations of cancer cells that are resistant to drug treatment and that these are selected for during the treatment process.

There are also some animal species — such as Tasmanian devils and domestic dogs — that are known to have transmissible cancer cells circulating within their populations.

Confocal microscopy further demonstrated an extensive network of nestin - positive cellular processes emanating from the transplanted cells present within the neurosensory retina (Figure 6C), which was not observed in the subretinal hNPCctx population.

Mass Cytometry is a next - generation flow cytometry technology that enables highly dimensional functional and phenotypic profiling of single cells within heterogeneous populations.

Consequently, within a population of beads, all possible orientations of the starting molecule will be represented and available for interactions with other molecules, complexes or cells.

Such performance - enhancing alterations will include reprogramming using non-integrating vectors or small molecules, the identification of the specific cell within the CS populations which provides therapeutic benefit, and the long - term consequences of CS cell transplantation.

Assuming that the findings of the review reflected a causal relation between smoking cessation and risk of all cause mortality, we further investigated the data by constructing life tables for a hypothetical group of 100 patients aged 65 years with early stage lung cancer to estimate how many deaths would be prevented by smoking cessation within the non-small cell lung cancer and small cell lung cancer populations during five years.

Our facility houses two third - generation Helios mass cytometers that can routinely analyze more than 40 markers per tube to provide an unprecedented «systems - level» view of phenotypic and functional variations among single cells within heterogeneous cell populations.

To determine the length of time required for the two states to interconvert we purified populations V+S + and V − S + cells and examined the extent to which the original distribution was re-established and observed significant changes in both populations within 24 h of plating (Figure 7B).

New CFSE - based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population.

Many in vivo processes, including morphogenesis or tumour maturation, involve small populations of cells within a spatially restricted region.

Thus we examined whether FGF signalling could alter the dynamics between the V + and V − states within the S + population by culturing HV cells in the presence of the FGFR inhibitor PD173074 [41] for 48 h.

Finally, that all cells within the population are synchronized during the saccade, and that the burst properties are determined by the saccade in which the cell participates, rather than by its location in the map, is not a model assumption either.

Microchimerism is the presence of small populations of genetically disparate cells within a host as a result of transfusion or transplacental trafficking during pregnancy, and may influence immune tolerance in the recipient.

While it has been demonstrated previously that more differentiated cells demonstrate a lower reprogramming efficiency [11] and different somatic cell types possess differential reprogramming ability [12], [13], no study to date, to our knowledge, has identified subpopulations of cells within a primary cell population possessing differential reprogramming potential.

A unique focus of my work is on the impact of heterogeneity within tumors and tumor cell populations, including subpopulations commonly referred to as «cancer stem cells», on the immune response.

These observations, which have provided striking insights into the epigenetic regulation of the molecular blueprint for pluripotency within ES cells, have been made at the population level, and thus reflect the summation of activity within all cells in the population.

Invivoscribe products identify clonal rearrangements within the immunoglobulin and T - cell receptor genes, which helps identify clonal B - and T - cell populations.

Single - cell transcriptomics serves as a powerful tool to identify cell states within populations of cells, and to dissect underlying heterogeneity at high resolution.

The overall picture is compatible with a model of multiple states of pluripotency within a highly dynamic cell population.

Finally, within the fractionated cell populations, there was evidence for coexpression of lineage specific markers alongside of pluripotency genes, similar to lineage priming described first in hematopoietic stem cells [15].

Interestingly, when we looked at the splenocytes in these mice and compared them to controls, we were not able to detect a significant difference in the numbers of Tregs, suggesting that in the transplant model, Tregs may be within the graft - infiltrating population where they could regulate infiltrating host T cells.

These assays also recognize conserved elements within the bioengineered immuno - therapeutic constructs of CAR - T and TCRs, making them robust candidates for dual use purposes: (1) identifying and monitoring immuno - therapeutic constructs in the peripheral blood and (2) identifying and monitoring clonotypes associated with malignant B - and T - cell populations.