Sentences with phrase «cell populations»

There is also a depletion and degradation of healthy regenerative stem cell populations in the body over time.

Today, cell biology is no longer limited to static states but also attempts to understand the dynamic development of cell populations.

The laboratory has contributed significantly to discovery of regulatory T cell populations that prevent immune responses to host cells and tissues.

This requires monitoring the different cell populations that make up the growing tumor and adjusting the schedule based on the data.

Our group is studying the use of various cell and stem cell populations for application in new cellular therapies.

Cell markers are helpful tools used to identify a specific immune cell population.

When they repeated their bone - marrow analysis, the same cell populations consistently appeared.

This finding comes as a surprise, considering that the average migration speed of the larger cell population does not change through multiple cycles.

In other words, a healthy cell population is one concurrent «mass of electrical energy» that can pass through this virtual «electrical circuit board» of the cells.

In the skin, distinct stem cells populations contribute to wound healing.

At each developmental stage, the researchers conducted single - cell RNA sequencing to identify unique gene expression patterns and assess the purity of individual cell populations.

However, it remains unclear how these different stem cells populations balance proliferation, differentiation and migration during the healing process.

The diminished ability for cells to grow is strongly associated with the aging process, with the reduced cell population directly contributing to weakness, illness, and organ failure.

The distributed timing model suggests that there is no dedicated timing system but that the ability to represent time is an intrinsic property of distributed cell populations that are required for a given task.

«A pivotal part of responsible translation to the patient is a clear understanding of relevant adult cell populations,» he added.

A major new insight is the realization that different tumors of the same type may rely on entirely different tumor stem cell populations.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

The lack of increase in T cell populations in dogs with nKCS strongly suggests that the changes in iKCS are causing the tear deficiency and not resulting from it.

Identify immune cell populations with our flow cytometry antibodies and kits and isolate them with our cell selection kits.

When coexpressed with a recombinase, these intracellularly expressed ssDNAs target specific genomic DNA addresses, resulting in precise mutations that accumulate in cell populations as a function of the magnitude and duration of the inputs.

Three - color flow cytometry analysis was performed to detect the CD44 + / CD24 - / ESA + cell population.

He confirmed the anti-tumor potential of OX40 in mice when antibodies that stimulated OX40 activity expanded the T cell population within tumors, and drove tumor regression.

When using the ClonTracer system, lentiviruses containing these barcodes infect the target cell population at low multiplicity of infection (MOI) such that each individual cell receives only one barcode.

A more targeted approach depletes a specific cell population in the graft: naïve T cells, which have not yet differentiated into specific types.

It is a bulk method that sorts different cell populations by tuning their solubility.

AST - OPC1, an oligodendrocyte progenitor cell population derived from human embryonic stem cells, has been shown in preclinical testing in animals and in vitro to have three potentially reparative functions that address the complex pathologies observed in demyelination disorders, such as spinal cord injuries, and multiple neurodegenerative diseases, including multiple sclerosis and white matter stroke.

Comparison of the differentiation potential of cell populations isolated from human lipoaspirate, trabecular bone tissue and periosteal tissue.

High contrast images facilitate robust automatic tracking and behavioural analysis of hundreds of individual cells within heterogeneous cell populations is now possible without the need for intrusive dyes or labels, bringing unique morphological, temporal, and dynamic phenotypic data to your research.

In the publication, Bhang and coworkers used the ClonTracer library to determine whether or not cancer cell populations resistant to drug treatments arise during treatment or are preexisting in the parent population prior to the start of treatment.

On average, the number of cells expressing both E-selectin and VCAM - 1 found in primary cultures ranged from 3 to 10 % of the total cell population.

They also express T cell activation markers, even (and to a great extent) in germ free mice, hence they appear to develop to become a natural memory cell population based on some type of internal antigen (s).

We present an in - depth characterization of human T cell populations using a panel of ~ 80 antibodies revealing complexity not previously observed by scRNA - seq alone.

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

In a large effort, the Teichmann (Wellcome Sanger Institute) and Shields groups (MRC Cancer Unit, University of Cambridge) worked together to collect immune and stromal cell populations from multiple replicate mice over an 11 - day timecourse.

However, here, we used a well - defined hematopoietic cell population derived from ES cells, and we showed the kinetics of their MHC expression.

A couple of other research groups have also sorted stem cells based on gene expression, but they have not done so specifically with the goal of enriching cell populations for a specific tissue, the researchers said.

In this work, we use the DNA of living cell populations as genomic «tape recorders» for the analog and distributed recording of long - term event histories.

Our laboratory used two monoclonal antibodies, GCTM - 2 and TG30, recognizing the cell surface proteoglycan characteristic of primate ES cells and CD9 respectively, to fractionate human ES cell populations into four compartments according to their relative levels of expression of both markers [14].

Despite remarkable improvement in the generation of hPSC - CMs, without purification, these protocols can only generate mixed cell populations including undifferentiated hPSCs or non-CMs, which may elicit adverse outcomes.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

The research team successfully identified a drug - resistant cell population within hemangiosarcoma tumors that may be an important player in chemotherapy resistance.

First author of the paper, Dr Christian Schwartz, a European Molecular Biology Organization Long Term Fellow in Professor Fallon's group, added: «It is fascinating that a small cell population such as the ILC2s can regulate the expansion of Th2 cells and thereby shape the whole outcome of an immune response — be it beneficial in case of parasitic infections, or detrimental as in the case of allergic responses.»

Without healthy naive cells to replace the defeated memory cells, the T cell population declines precipitously.

The press release from Lund University accompanying this article was titled «Breakthrough On Huntington's Disease», and contained a quote from Dr Petersen stating «We are the first to show that it is possible to prevent the depression symptoms of Huntington's disease by deactivating the diseased protein in nerve cell populations in the hypothalamus in the brain».

Along with steroids, the mainstay of GVHD treatment today is drugs that turn down the production of IL - 2, a cytokine that helps T cell populations expand and diversify.

Janbazian L, Price DA, Canderan G, Filali - Mouhim A, Asher TE, Ambrozak DR, Scheinberg P, Boulassel MR, Routy JP, Koup RA, Douek DC, Sekaly RP, Trautmann L. Clonotype and repertoire changes drive the functional improvement of HIV - specific CD8 T cell populations under conditions of limited antigenic stimulation.