Sentences with phrase «cell populations as»

Through image analysis of breast tumors and TDLNs, we have found that immune cell populations as well as their spatial distributions and clustering patterns have strong correlation with clinical outcome.

This murine model system offers a superior source of immortalized cell populations as many of the difficulties associated with the in vitro transfection process are eliminated (e.g., initial requirement for many cells, different sites of gene integration, multiple copy number; Ref.

In this work, we use the DNA of living cell populations as genomic «tape recorders» for the analog and distributed recording of long - term event histories.

When coexpressed with a recombinase, these intracellularly expressed ssDNAs target specific genomic DNA addresses, resulting in precise mutations that accumulate in cell populations as a function of the magnitude and duration of the inputs.

Not exact matches

(i) a woman's right to choose; (ii) teaching evolution in school; (iii) medical immunization of teen girls against HPV; (iv) assisted suicide; (v) gay marriage; (vi) my right to view art and theatre deemed «offensive,» «blasphemous» or «obscene» by theists (vii) basic $ ex education for older school children; (viii) treating drug abuse as principally a medical issue; (xi) population control; (x) buying alcohol on a Sunday; (xi) use of condoms and other contraceptives (xii) stem cell research.

We increase the number of homeless shelters and food pantries, restore the welfare entitlement, build more prison cells, and write off a substantial part of the population as permanently incapable of citizenship.

(i) a woman's right to an abortion; (iii) medical immunization of teen girls (and boys) against HPV; (iv) assisted suicide; (vi) gay marriage; (vii) my right to view art and theatre deemed «offensive,» «blasphemous» or «obscene» Catholics; (viii) basic $ ex education for older school children; (ix) treating drug abuse as principally a medical issue; (x) population control; (xi) buying alcohol on a Sunday in many places; (xii) use of condoms and other contraceptives; (xiii) embryonic stem cell research; (xiv) little 10 year - old boys joining organizations such as the Boy Scouts of America, regardless of the religious views of their parents; and (xv) gays being allowed to serve openly in the military.

With 212 million cell phone users in the US — about 75 % of the population — the potential for using mobile phones («mo - phos,» as the kids call them) as a tool to grow your organization's visibility and spread your message is enormous.

Campaign staff also relied on cell phones to reach segments of the population less likely to be on a computer regularly, such as young people, minorities and the poor.

Scientists could build chips containing cells from patients with specific genetic mutations, which could predict drug responses in specific populations, as well as personalized chips that predict an individual's drug response.

Prof. Jean - Christophe Marine (VIB - KU Leuven): «Unexpectedly, this ability to divide and contribute to melanoma development contrasted with the activities of other cell populations, such as melanocyte stem cells found in hair follicles, for instance.

Instead, the team used functional magnetic resonance imaging (fMRI) to detect populations of cells that seemed to fire as the volunteers played a virtual reality game in which they had to replace an object in the location where they originally found it.

As Goutsias explains, this distribution reflects the chance that a particular region of a genome will be methylated in a population of similar cells.

However, along with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with anti-estrogen drugs like tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

The KU researcher said that new evidence suggests that cancer originates and progresses by a small population of cells known as cancer stem cells.

As they grow, mutations arise and populations of genetically distinct cells emerge.

A University of Wyoming faculty member led a research team that discovered a certain type of soil bacteria can use their social behavior of outer membrane exchange (OME) to repair damaged cells and improve the fitness of the bacteria population as a whole.

Dr Ignacio Vazquez - Garcia, the first author from the Wellcome Trust Sanger Institute and University of Cambridge, said: «We found that the degree of diversity within the cell population — known as clonal heterogeneity — played a major role in the acquisition of antimicrobial resistance.

Human epidemiology studies in populations in different geographic locations, as well as clinical and molecular studies, show that Merkel cell polyomavirus causes Merkel cell carcinoma.

Nearly all of the cancer cells died as a result, but a residual population of tumor cells survived and became dormant.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

For instance, researchers often use so - called «gene guns» to fire particles coated with strands of DNA known as plasmids at large populations of cells.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.

By measuring for the presence of a molecule associated with cell division, the scientists determined that this residual population of dormant cancer cells consisted of an indolent as well as a quiescent population.

Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.

Scientists have found some serious loot in that bemoaned organ, including a vigorous population of flexible stem cells that can be coaxed into acting as new cartilage or tendons for damaged joints.

«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»

First author of the paper, Dr Christian Schwartz, a European Molecular Biology Organization Long Term Fellow in Professor Fallon's group, added: «It is fascinating that a small cell population such as the ILC2s can regulate the expansion of Th2 cells and thereby shape the whole outcome of an immune response — be it beneficial in case of parasitic infections, or detrimental as in the case of allergic responses.»

The research team of Professor Michiels showed that the number of tolerant cells in a population increases as bacteria are exposed to antibiotics more often: daily doses have a bigger impact than weekly doses.

Moreover, the stressed mice's gray hairs and the cell populations in their follicles were indistinguishable from those of elderly mice, suggesting that genotoxic stress might drive natural graying as well.

National Institutes of Health researchers studying zebrafish have determined that a population of cells that protect the brain against diseases and harmful substances are not immune cells, as had previously been thought, but instead likely arise from the lining of the circulatory system.

«It was once believed that effector and memory cells arose as two distinct populations, with some cells initially fated to be effector type and some to be memory,» McDonald said.

The code that a monkey's brain uses to represent faces relies not on groups of nerve cells tuned to specific faces — as has been previously proposed — but on a population of about 200 cells that code for different sets of facial characteristics.

«Secondary benefits of this trial include the significant improvement in clinical care for children with sickle cell disease at each of the 29 sites because each location had a designated hematologist, neurologist, neuroradiologist and psychologist working as a team to identify and decrease further injury to the brain in this vulnerable population.»

DFTD is an asexually reproducing clonal cell line, which during the last 16 years has been exposed to negative effects as infected devils, approximately 33 % of the population, have been removed from one site, the Forestier Peninsula, in Tasmania between 2006 and 2010.

They thus conclude that an increased level of this Treg cell population could serve as an early diagnostic indicator of a predisposition to allergic diseases.

Instead of looking at these active stem cells, Lengner's group examined a second population of intestinal stem cells known as reserve stem cells.

The research group plans to move forward with more - advanced technology and larger populations to investigate field cancerization in other lung cancer subtypes, such as small - cell lung cancer, in smokers and in lung cancers that develop in non-smokers.

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

What's really impressive about Babar's accomplishment is that he did the work for both papers — one on the role of a population of stem cells in lung cancer development (published in Cell) the other on gene expression in group A Streptococcus (published in PNAS)-- as a participant in summer undergraduate research programs.

The limited number of permissible cell lines left, Melton says, can not meet the medical needs of a population as genetically diverse as the human race.

They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end caps» on chromosomes, which indicates prematurely aged cells.

Border cells are relatively sparse, making up less than 10 % of the local cell population, but can be found in all layers of the medial entorhinal cortex as well as the adjacent parasubiculum, often intermingled with head - direction cells and grid cells.

This finding comes as a surprise, considering that the average migration speed of the larger cell population does not change through multiple cycles.

The classical concepts of angiogenesis consider the endothelial cells within tumors as a rather passive cell population that merely reacts in response to growth factors released by the tumor cells.

From these three cell populations different functional tissue cells arise, such as skin cells, muscle cells, and specific organ cells.

A failure of immune cells to keep the gut microbe population in check can lead to chronic gut inflammation, manifesting as IBD.

«Knowing about these Lgr5 cells is valuable for us because it gives us a target cell population to study as we try to figure out how to better manipulate them and turn them into hair cells in an adult,» Edge says.

In principle, tissue banks of parthenogenetic cell lines could include enough different immune protein combinations to treat up to half of the U.S. population — men as well as women — Lanza says.