Sentences with phrase «cell populations expand»

Along with steroids, the mainstay of GVHD treatment today is drugs that turn down the production of IL - 2, a cytokine that helps T cell populations expand and diversify.

Not exact matches

He specifically wants to expand the population of stem cells that will induce regeneration of neurons and blood vessels in patients who have suffered a hemorrhagic stroke, the kind of stroke which is caused by blood clot.

With treatment, T - cell subtypes normally associated with allergic responses diminished, while a novel T - cell population that likely would not mount an allergic response expanded.

«We have discovered that by timing the inhibition of STAT3 — like an «on / off» light switch — we can transiently expand the satellite - cell population followed by their differentiation into mature muscle cells.»

Separately, the high levels of a type of T cell called Th17 cells secrete gobs of interleukin - 17 (IL - 17), expanding macrophage populations.

So I [thought], I know a little bit of immunology, I know a little bit of engineering, and I really want to talk about developing systems that can modulate antigen presentation or expand T cell populations in a specific direction.

Antibodies stimulate the recruitment of additional immune cells that help to activate T cells; the vaccine stimulates proliferation of T cells that can attack the tumor; IL - 2 helps the T cell population to expand quickly; and the anti-PD1 molecule helps T cells stay active longer.

In healthy individuals, MDSCs regulate immune responses and tissue repair, and the population of these cells rapidly expands during inflammation, infection and cancer.

Dr. Angulo and his team plan to expand on their findings about this specific patient population by examining data beyond BMI, including fat distribution and differences in cell signaling proteins, such as cytokine and adipokine profiles.

In addition to providing metabolic support to the expanding tumor population, the newly formed vessels also facilitate tumor cell entry into the systemic circulation (6).

«This new understanding of the role played by scrawny may make it easier to expand stem cell populations in culture, and to direct stem cell differentiation in desired directions,» says Spradling.

Presently, human pluripotent stem cells (hPSCs) are the most powerful cellular resource to challenge this complete reassessment of the scientific bases and goals of toxicity testing, since they present a unique opportunity to develop a wide variety of human cell - based physiological test systems because they may be expanded indefinitely and triggered to differentiate into any cell type, offering additionally the possibility to represent the human population diversity.

Immature DC that are loaded with antigen can silence T cells by deletion or by expanding Treg populations 114, 115.

Dr. Studer and colleagues isolated and cloned a population of neural rosette cells (R - NSCs), which have an expanded neuronal subtype differentiation potential.

Advanced reproductive techniques such as artificial insemination, culturing of primordial germ cells for germ - line transmission, stem cell embryogenesis, and cloning offer an array of new ways to expand and even infuse lost and new genetic variability into at - risk wildlife populations.

We found that CMV - specific CD4 + T cells were significantly expanded in healthy young and old carriers compared with purified protein derivative -, varicella zoster virus -, EBV -, and HSV - specific populations.

Non-adherent cells are removed after overnight culture and adherent populations are expanded under low density conditions (seeding density 1000 cells / cm2 and allowed to grow upto 60 — 70 % confluency).

It is tantalizing to speculate that amiodarone HCl might also be toxic to other stem cell populations that demonstrate increased ion channel expression relative to their differentiated derivatives, including mesenchymal stem cells (MSCs) and endothelial precursor cells [36], thus expanding the utility of the automated screening assay described here.

Antibody titres are not boosted significantly, memory cell populations are not expanded.