Sentences with phrase «cell populations from»

To determine whether adipose tissue macrophages express any molecules implicated in obesity - associated complications, we isolated three cell populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched population, (b) a stromal vascular macrophage F4 / 80 + population, and (c) an F4 / 80 — stromal vascular population.

Since HIV infection itself alters epigenetic processes in the immune system, the research team wondered whether a distinct DNA methylation profile, a major epigenetic modification where methyl groups are added to DNA, occurs in those with HIV associated - cognitive impairment and whether it exists in distinct immune cell populations from the blood.

Developing therapeutic cell populations from human ES cells will be far more demanding: cells will have to be stable, predictable, pure, have proven functionality, be nontumor - forming, and be «scalable» — capable of growing in very large numbers.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.

To further clarify this notion, we examined the specificity of miR - 7 expression in CSCs and non-stem cell population from MDA - MB231, 231BoM, and 231BrM.

Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).

«Often, we want to generate a particular cell population from stem cells for introduction into patients,» says co-senior author Young - sup Yoon, MD, PhD, professor of medicine (cardiology) and director of stem cell biology at Emory University School of Medicine.

The Fab fragment of mAb 5.91, pre-incubated with canine IgE, reduced the binding of canine IgE to the monocyte cell population from 15 % to 5.6 %.

Results showed that the whole mAb 5.91 molecule reduced the amount of binding of canine IgE to the monocyte cell population from 15 % to 7.7 %.

Not exact matches

And with 7billion on the planet (and growing), these «young people missing millions from their generation» should be thankful that clusters of cells can be medically removed, preventing unwanted births and (perhaps) even saving the human population from growing to a point of unsustainability.

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

I know it's popular to think of movies where Floyd is sharing his cell with a hardened criminal and having to worry about being shanked, but it's much more likely that he spends a bunch of time away from general population, being kept safe and probably watching TV and reading his days away.

Sampling was conducted via a stratified dual frame probability sample of landline and cell phone telephone numbers (both from Survey Sampling International) from within New York State weighted to reflect known population patterns.

They're not the only ones, of course, since political organizers from Manila to D.C. have found that cell phones are profoundly political devices, particularly when they reach populations that are otherwise effectively off the grid.

Sampling was conducted via a stratified dual frame probability sample provided by Survey Sampling International of landline and cell phone telephone numbers from within New York State weighted to reflect known population patterns.

The government has been forced to introduce emergency measures to tackle a bursting jail population, which includes using police cells from today.

Scientists could build chips containing cells from patients with specific genetic mutations, which could predict drug responses in specific populations, as well as personalized chips that predict an individual's drug response.

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

From single - celled organisms to human populations, viruses affect all life on earth, often determining what will survive.

In the course of examining single unit responses from the cortex of unrestrained and unanesthetized cats, we have come upon a population of cells that appears to be sensitive to auditory stimuli only if the cat «pays attention» to the sound source.

Through a variety of «high tech» approaches, including the isolation of monoclonal antibodies from single B cells and ultra-deep sequencing of shifting viral populations over more than three years of infection, the researchers studied one woman who developed potent broadly neutralizing antibodies.

In order to thoroughly investigate cures for a diverse population, cell lines from a large sampling of individuals are needed.

We don't need to use a cocktail of small molecules, growth factors or other supplements to create a population of bone cells from human pluripotent stem cells like induced pluripotent stem cells,» Varghese said.

He then evaluated the levels of specific microRNAs in populations of highly metastatic, compared to poorly metastatic, cancer cells taken from the same patient.

Although some teams have managed to produce nearly pure colonies of certain kinds of neural cells from ES cells, no one has managed to concoct a recipe that will direct the cells to become, say, a pure population of dopamine - producing neurons that could replace those missing in Parkinson's disease.

Next, they used a technique called fluorescence - activated cell sorting to separate out the newly differentiated retinal ganglion cells from a mixture of different cells into a highly purified cell population for study.

Dr Ignacio Vazquez - Garcia, the first author from the Wellcome Trust Sanger Institute and University of Cambridge, said: «We found that the degree of diversity within the cell population — known as clonal heterogeneity — played a major role in the acquisition of antimicrobial resistance.

Professor Gianni Liti, a senior author on the paper from the Institute for Research on Cancer and Ageing, Nice, said: «We were able to study the evolution in time by combining genome sequences of the cell populations and tracking the growth characteristics of the yeast cells.

Using only the DNA from sloughed - off cells floating in the ocean, scientists have been able to determine the population size and genetic properties of one of the world's largest and most mysterious animals: the whale shark.

Now, researchers reporting February 25 in Cell Reports describe an intermediate gut microbiome from the Central African Republic's Bantu community, a traditional population that incorporates some westernized lifestyle practices.

Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.

Using fluorescent markers, Fuchs and her colleagues isolated two distinct populations of stem cells from mouse skin.

«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

«By combining the genetic analysis of a small population of immune cells from healthy skin with functional experiments we were able to define two subgroups of memory immune cell and in detail decipher / dissect how these cells behave in healthy and inflamed skin,» explains Liv Eidsmo, researcher at Karolinska Institutet's Department of Medicine.

Moreover, the stressed mice's gray hairs and the cell populations in their follicles were indistinguishable from those of elderly mice, suggesting that genotoxic stress might drive natural graying as well.

National Institutes of Health researchers studying zebrafish have determined that a population of cells that protect the brain against diseases and harmful substances are not immune cells, as had previously been thought, but instead likely arise from the lining of the circulatory system.

In the cases, just this last couple of elections, where stem cell politics, for example, has been played out in the electoral process, stem cell research is [has] done better than the winning candidates for offices; and I think, apart from that, I think that we do have a serious problem in general education of the sciences and that accounts for the reluctance of a large segment of the population to accept the principles of evolution and think that there is still a debate about it, which there isn't — and that's a problem we need to solve, — but I still think there is an incredible constituency for science in this country.

Therefore, adult stem cells become exhausted in aged individuals due to telomere length shortening that results in increased healing times and organ tissue degradation from inadequate cell populations.

Dr Saraswat explained that the impact of endometriosis — a relatively common condition in which cells from the lining of the uterus (endometrium) are found elsewhere in the pelvic area — is relatively unknown in pregnancy in general populations of women, with most studies performed in infertile women having assisted reproduction.

For that, they quantified how 85 nanoparticles delivered DNA barcodes to eight cell populations in the spleen, and found that cell types derived from myeloid progenitors tended to be targeted by similar nanoparticles.

Conservation work to defeat the disease has including removing infected individuals from the population and new research in Evolutionary Applications explains how this gives us a unique opportunity to understand how human selection alters the evolution of cancerous cells.

DFTD is an asexually reproducing clonal cell line, which during the last 16 years has been exposed to negative effects as infected devils, approximately 33 % of the population, have been removed from one site, the Forestier Peninsula, in Tasmania between 2006 and 2010.

«When we got those results everybody was really excited about it, because pulling out epigenetic changes from a cell population during an infection in vivo is really pretty remarkable,» Tarrio said.

Therefore, researchers from the CNIO's Experimental Oncology Group have focused their work on identifying a stromal cell population that fosters tumour growth, to later discover why they have this capacity and reverse it.

On the other hand, if the same mutation occurs in a different cell population located farther away from the SVZ, it will give rise to other subtypes,» said Chen.

Lepidoptera genetics is notorious for the fact that chromosome counts can vary between populations of the same species and occasionally even within cells from the same individual, he explains.

The team also demonstrated the utility of the platform by applying it to examine a growth - modulating feedback circuit whose dynamics is qualitatively altered by circuit - host couplings and revealing the behaviors of a toggle switch across scales from single - cell dynamics to population structure and to spatial ecology.

With the results from both Korea and the UK the presence of both diet and microbe - induced populations of pTreg cells may be required for the development of complete tolerance to food antigens.