Sentences with phrase «cell precursors»
"Cell precursors" refers to immature cells that have the potential to develop into specific types of cells in the body. They are like the building blocks from which mature cells are formed. Full definition
City of Hope today announced that it is a certified treatment center to administer tisagenlecleucel (commercial name Kymriah) chimeric antigen receptor (CAR) T cell therapy — the first CAR T cell therapy approved by the U.S. Food and Drug Administration (FDA)-- to patients up to 25 years of age with B cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse.
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Malaysian scientists have provided evidence that a widely used chemical is more toxic to certain blood cell precursors in the bone marrow than to others.
One company, Melbourne, Australia — based Mesoblast, is already in late - stage clinical trials, treating hundreds of chronic heart failure patients with stem cell precursors drawn from healthy donors» hip bones.
The other kind is peritubular — that is, located on the surface of the seminiferous tubules that house sperm cell precursors.
The patient, a 53 - yr - old male diagnosed with early T - cell precursor leukemia (ETP - ALL), was not responding to previous rounds of chemotherapy.
Ultimately, this activity increases cellular regeneration, or self - renewal, turning white blood cell precursors into leukemia stem cells.
Usually imprinting marks are erased in the germ cell precursor cells and then rewritten in the eggs or sperm.
Why leukemic cells and normal blood cell precursors respond so differently to this treatment requires further investigation.
But, as these B - cell precursors went down a developmental path toward becoming B cells, Xist RNA first seemed to disappear, then reappear, but only as diffuse pinpricks across the nucleus instead of being localized to the inactive X.
«Insights into the development of sperm and egg cell precursors in the embryo.»
«A few years ago, researchers showed that it's possible to do this, completely bypassing the stem cell precursor state,» says Mertens.
The thymus, a strawberry - size gland in the chest, produces a steady stream of T cell precursors in our youth.
Importantly, the findings suggest that, if Merkel cell carcinoma does arise from Merkel cell progenitors, then Atoh1 - positive Merkel cell precursors could be the cells of origin.
The antibody fragment was selected because it uniquely binds to the cell membranes of red blood cell precursors while avoiding other types of blood cells that control clotting and vessel growth.
Researchers at University of California San Diego School of Medicine have now unraveled how pre-leukemic white blood cell precursors become leukemia stem cells.
The dorsal region spontaneously developed three layers along the dorsal - ventral axis: the ventricular zone, a Purkinje - cell precursor zone, and a rhombic lip zone.
The mice do, however, have a small number of gut neurons from an unexpected source — cells called Schwann cell precursors (SCPs).
By carefully guiding the cells» choices at each fork in the road, Loh and Chen were able to generate bone cell precursors that formed human bone when transplanted into laboratory mice and beating heart muscle cells, as well as 10 other mesodermal - derived cell lineages.
Her newest project, funded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, will look at the crucial time when malaria is transmitted — when reproductive cell precursors known as gametocytes develop.
The existence of ES cell precursors to this lineage is supported by the observed heterogeneous expression of other PrEn genes, Lefty1, Cerl, and Gata6 in the ICM of blastocyst stage embryos, the stage from which ES cells are derived [17], [44]--[46].
In a study published earlier this year, the same Belmonte and Gage lab team demonstrated that a few ES cells in a culture dish tended to lose stemness and evolve into muscle cell precursors, most likely goaded by a muscle differentiation factor known as BMP.
Besponsa is approved for adults with hard - to - treat or recurring forms of B - cell precursor acute lymphoblastic leukemia (ALL), which nearly 6,000 Americans are diagnosed with each year.
By the time a man is 40, each of his sperm cell precursors, called spermatogonia, has divided approximately 660 times, or about 23 times a year after puberty, in order to give rise to sperm.
In theory it is possible to transform either somatic cells (most cells of the body) or cells of the germline (such as sperm cells, ova, and their stem cell precursors).
In March, the U.S. Food and Drug Administration (FDA) approved BLINCYTO for the treatment of adults and children with B - cell precursor acute lymphoblastic leukemia in first or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1 percent.
The drug, which was first approved last August for patients under 25 with B - cell precursor acute lymphoblastic leukemia, is now OK» ed to treat large B - cell lymphoma.
Nadeau stumbled upon one study, in mice, describing how environmental factors can tag Foxp3 with chemical markers that tell T - cell precursors to switch the gene on or off.
«Common chemical highly toxic to blood cell precursors.»
Much like chemotherapy's well - known ability to decrease red and white blood cell precursors transiently, methotrexate or cyclophosphamide depleted fat cell precursors, leading to much decreased fat storage.
They observed that the fly was born alive but without wings; so the removal of this molecule caused the death of all cell precursors of this tissue (if histone 1 is removed from the entire fly, the embryo dies).
The US Food and Drug Administration has approved blinatumomab (Blincyto) for patients in remission from B - cell precursor ALL with MRD.
A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.
The FDA also recently approved blinatumomab (Blincyto) for the treatment of B - cell precursor ALL in adult and pediatric patients.
The US Food and Drug Administration (FDA) has approved inotuzumab ozogamicin (Besponsa) for the treatment of relapsed or refractory B - cell precursor acute lymphoblastic leukemia (ALL) in the adult population.
The genetic basis of early T - cell precursor acute lymphoblastic leukaemia Nature, 481 (7380), 157 - 163 DOI: 10.1038 / nature10725
Other CAR T - cell therapies approved in 2017 include tisagenlecleucel for the treatment of children and young adults up to 25 years of age with relapsed or refractory B - cell precursor acute lymphoblastic leukemia and axicabtagene ciloleucil (aci - cel; Yescarta) for adults with relapsed or refractory DLBCL.
Modeling the evolution of ETV6 - RUNX1 - induced B - cell precursor acute lymphoblastic leukemia in mice.
The FDA has approved inotuzumab ozogamicin (Besponsa) for the treatment of adults with relapsed or refractory B - cell precursor acute lymphoblastic leukemia.
They usually are the result of acquired (not inherited) genetic mutations that occur only in the red blood cell precursors that lead to ringed sideroblasts.
The tour offered viewers the chance to see the most comprehensive survey to date of her sculpture series Cells (twenty - eight of them), alongside «cell precursors», other sculptures, drawings and paintings.