Researchers at University of California San Diego School of Medicine have now unraveled how pre-leukemic white blood
cell precursors become leukemia stem cells.
Not exact matches
Smell neurons begin as identical
precursor cells, immature
cells that have not yet «decided» which type of nerve
cell they will
become.
If these
precursor cells can be coaxed into
becoming fully functioning sperm
cells, the technique could allow infertile men to father their own children, and even allow women to produce their own sperm.
These egg - generating
cells are germline stem
cells —
precursors that
become either eggs or sperm depending on whether they end up in ovaries or testes.
In response to muscle damage, these stem
cells divide to generate
precursor cells that
become the fibres that make up our muscles.
Because the
cells that give rise to sperm divide frequently — about 23 times a year — they are much more likely to accumulate genetic copying errors than the female
precursor cells, oocytes, which divide only twice before
becoming eggs.
In theory, if the
precursor cells can be pushed to mature into adulthood, they may
become capable of producing myelin.
«At least part of the problem is that the
precursor myelin - producing
cells are recruited to that area, but they fail to
become adult
cells capable of producing nerve
cell insulation.
Monje first
became interested in neurons» role supporting tumors while working on childhood glioma, a cancer that strikes in the
precursors to glial
cells in the developing brain.
One concerning discovery was that the stem
cells that Zika was found to infect, called cortical neural
precursors,
become factories for viral replication.
Jeanne Loring, a stem -
cell biologist at the Scripps Research Institute in La Jolla, California, who is also planning stem -
cell trials for Parkinson's, is concerned that the Australian and Chinese trials use neural
precursors and not ES -
cell - derived
cells that have fully committed to
becoming dopamine - producing
cells.
By adding vitamin D to a petri dish full of osteoclast
precursors, they discovered that the hormone blocked a signal called RANK ligand that tells these
cells to
become osteoclasts.
In these droplets he can simulate how the chemical
precursors to life
became the
cells we know today.
Subsequently, some aerobic (or oxygen - breathing) protists merged with photosynthetic bacteria, which
became chloroplasts and other plastids, to create free - swimming green algae and the
precursors of today's plant
cells.
«We can take human brown fat
precursor cells, grow them in Petri dishes and then culture them to
become energy - dissipating
cells,» says Dr. Tseng.
They then experimented with varying combinations of well - known signaling molecules, including WNT, BMP and Hedgehog, as a way to coax these
cells to
become ever - more - specialized
precursor cells.
For example, there is no equivalent of indefinitely self - renewing embryonic stem
cells in the human embryo — these are instead transient
cells that very quickly specialise to
become the
precursors of tissues in the embryo.
Fortunately, we've found a way round this to allow us to commit the
precursor cells to
become the right dopamine
cells without the other
cells appearing after grafting.»
«They are the closest
precursor to functional heart
cells, and, in a single step, they can rapidly and efficiently
become heart
cells, both in a dish and in a live heart.
When the embryo is at the 16 -
cell stage (called a morula), it is a solid sphere of
cells and already the
precursors of the trophoblast
cells are defined; the external, relatively larger
cells mostly
become the trophoblast
cells.
«You take stem
cells and programme them to
become «neural
precursor cells».
In his laboratory mice, Dr. Ding has now used chemical reprogramming to turn fibroblasts into neural «
precursor»
cells with the potential to
become new oligodendrocytes.
In terms of mechanism, the authors found that the presence of H. hepaticus, even as it triggers inflammation via Th17
cells, also indirectly turns on genes that instruct immature
precursor T
cells to
become Tregs.
The piece mentioned that some of the funds would support ViaCyte and our efforts to develop and test the VC - 01 ™ product, comprised of an implantable device that holds
precursor cells that upon implant in a patient are expected to differentiate to
become pancreatic islet
cells that produce insulin and other blood sugar - regulating hormones.
In their paper, co-authors Lei Sun and Huangming Xie describe for the first time the cellular network that determines whether a
precursor cell becomes a muscle
cell or brown fat
cell and miR - 193b - 365's role in this network.
These
precursor cells, although they haven't accumulated lipids, can potentially
become fat
cells.