Sentences with phrase «cell precursors in»

He is a pioneer of the field called «adult stem cell biology» and has isolated of various blood cell precursors in mice.

«Insights into the development of sperm and egg cell precursors in the embryo.»

Not exact matches

In March, the U.S. Food and Drug Administration (FDA) approved BLINCYTO for the treatment of adults and children with B - cell precursor acute lymphoblastic leukemia in first or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1 percenIn March, the U.S. Food and Drug Administration (FDA) approved BLINCYTO for the treatment of adults and children with B - cell precursor acute lymphoblastic leukemia in first or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1 percenin first or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1 percent.

Usually imprinting marks are erased in the germ cell precursor cells and then rewritten in the eggs or sperm.

The suggestion is that a small number of such cells within tumours may be the precursors to the other cancer cells in those tumours.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of PennsylvaniIn preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvaniin PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

This protein is expressed at relatively high levels in proliferating precursors and non-neuronal cells but down - regulated in developing neurons by a brain - enriched regulatory RNA called miR - 9.

One company, Melbourne, Australia — based Mesoblast, is already in late - stage clinical trials, treating hundreds of chronic heart failure patients with stem cell precursors drawn from healthy donors» hip bones.

Nadeau stumbled upon one study, in mice, describing how environmental factors can tag Foxp3 with chemical markers that tell T - cell precursors to switch the gene on or off.

During normal brain development in the first weeks of life, precursor cells in the SVZ in the piglets give birth to neurons that migrate primarily to the prefrontal cortex, the team reports today in Science Translational Medicine.

«Esophageal cancer «cell of origin» identified: In mice, basal progenitor cells give rise to Barrett's esophagus, a precursor to cancer.»

But researchers reporting online April 14 in Nature Cell Biology claim they have found precursor stem cells in newborn and adult mice that could be prodded into producing new eggs.

Ductal carcinoma in situ (DCIS) is a precursor of breast cancer where the cancerous cells are contained within the milk - making ducts.

The brains of the human babies with CHD that died in the first month of life also showed a depletion of neural precursor cells in the SVZ.

In newborn mammals, the SVZ is the biggest depot for the precursor cells that migrate to populate various brain regions, and differentiate into multiple cell types.

In theory it is possible to transform either somatic cells (most cells of the body) or cells of the germline (such as sperm cells, ova, and their stem cell precursors).

Columbia University Medical Center (CUMC) researchers have identified cells in the upper digestive tract that can give rise to Barrett's esophagus, a precursor to esophageal cancer.

That's consistent with earlier in vitro findings that Zika can infect and damage human neural precursor cells.

These egg - generating cells are germline stem cells — precursors that become either eggs or sperm depending on whether they end up in ovaries or testes.

Tanyi and colleagues made each patient's vaccine by sifting through the patient's own peripheral blood mononuclear cells for suitable precursor cells, and then growing these, in the lab, into a large population of dendritic cells.

In 1868, however, the German pathologist Ernst Neumann discovered immature precursor cells in bone marrow, which turned out to be the actual site of blood cell formation, also known as hematopoiesiIn 1868, however, the German pathologist Ernst Neumann discovered immature precursor cells in bone marrow, which turned out to be the actual site of blood cell formation, also known as hematopoiesiin bone marrow, which turned out to be the actual site of blood cell formation, also known as hematopoiesis.

In a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipIn a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tips.

«The effect of the precursors that boost NAD is to counteract the decline that occurs with normal aging, to reactivate SIRT1, and to restore function in endothelial cells to give rise to more blood vessels.»

With careful observation and experiments with mouse oocytes, the precursors of eggs, they've detected molecular signals that create an asymmetry in the machinery that drives meiosis, the cell - division process that gives rise to gametes.

Klingelhutz and his team immortalized immature precursor fat cells by adding in two genes from HPV (the virus that causes cervical cancer) along with a gene for part of an enzyme that controls the length of cells» telomeres — the pieces of DNA that protect chromosome tips from deterioration.

In PLAT - 02, the CAR T cells are reprogrammed to recognize and target the CD19 protein that is expressed by most precursor B acute lymphoblastic leukemia cells.

And in the third paper, published online today in Science, developmental biologists and stem cell researchers Hugo Snippert, Arnout Schepers, Hans Clevers, and their colleagues at the Hubrecht Institute in Utrecht, the Netherlands, used mice with multicolored intestines to look at the kinds of cells that form intestinal adenomas, a precursor to intestinal cancer.

It was known that a precursor of macrophages — roving cells deployed by the immune system to consume bacteria and dead cells — speeds up fat deposition in scarred arteries.

Even though the reproductive age for humans is around 15 — 45 years old, the precursor cells that go on to produce human eggs or sperm are formed much earlier, when the fertilized egg grows into a tiny ball of cells in the mother's womb.

He and his colleagues report online in Nature that in mouse papilloma tumors, a precursor to skin cancer, most of the tumor growth came from a few cells, which in some ways resembled the stem cells that maintain healthy skin.

Islet autoimmunity, detected by antibodies that appear when the immune system attacks the islet cells in the pancreas that produce insulin, is a precursor to type 1 diabetes.

In cell - based tests, Banfi and his colleagues showed that Noxo1 and Nox3 work together to produce superoxide, a precursor of oxygen free radicals.

These immortal precursor cells could then be «grown up» in petri dishes and differentiated into normal fat cells.

These results placed the resident OPC population in the focus of interest: what are the signals that control and enable the activation of these precursor cells in the adult zebrafish spinal cord?

• Fred Gage and his colleagues at the Salk Institute in La Jolla, California, harvested brain cells from human cadavers and used them to form neural progenitor cells, precursors to adult human brain cells.

Though the diesel product itself is not very dangerous to E. coli, several of its precursors, like fatty acids and ethanol, can harm the cell in high concentrations.

When human stem cells develop into beta cells in a dish, they only reach a precursor stage, unable to fully mature; this prevents them from effectively producing insulin in response to glucose.

We identified distinct clusters of CD4 - CTL effector and precursor cells in the TEMRA subset; the precursor cells shared TCR clonotypes with CD4 - CTL effectors and were distinguished by high expression of the interleukin - 7 receptor.

The team showed in mouse models that these two types of cells originate from a common precursor stem cell in the embryo.

The study introduced here focused on a population of support cells in the spinal cord that helps to protect surviving nerve cells (neurons) after injury: oligodendrocytes and their precursor cells.

In response to muscle damage, these stem cells divide to generate precursor cells that become the fibres that make up our muscles.

«We now know that precursors cells can be reprogrammed in a way that function is impaired at the final stage of their development, but so far no one has discovered how to reverse the process.

For example, antibody studies showed that it is located in the Golgi apparatus and endosomes, two structures within cells in which b - amyloid is known to be cleaved from its large precursor protein.

Precursor cells are cells that have not yet matured to undertake a specific function in the body, e.g. the function of a muscle or fat cell.

In the current study, Dr. Rudnicki and his team discovered that muscle stem cells also express the dystrophin protein, and without this protein, they produce ten-fold fewer muscle precursor cells, which in - turn generate fewer functional muscle fibreIn the current study, Dr. Rudnicki and his team discovered that muscle stem cells also express the dystrophin protein, and without this protein, they produce ten-fold fewer muscle precursor cells, which in - turn generate fewer functional muscle fibrein - turn generate fewer functional muscle fibres.

Previously, researchers have shown that treating cells with neuregulin - 1, for example, dampens levels of amyloid precursor protein, a molecule that generates amyloid beta, which aggregate and form plaques in the brains of Alzheimer's patients.

In theory, if the precursor cells can be pushed to mature into adulthood, they may become capable of producing myelin.

Researchers at the Cells - in - Motion Cluster of Excellence at the University of Münster (Germany) have now developed a method enabling them to better evaluate and study the activity of inflammatory cells in mice: they have succeeded in genetically modifying precursors of immune cells, then increasing their numbers in a test tube and finally tracking them spatially and temporally in living organCells - in - Motion Cluster of Excellence at the University of Münster (Germany) have now developed a method enabling them to better evaluate and study the activity of inflammatory cells in mice: they have succeeded in genetically modifying precursors of immune cells, then increasing their numbers in a test tube and finally tracking them spatially and temporally in living organcells in mice: they have succeeded in genetically modifying precursors of immune cells, then increasing their numbers in a test tube and finally tracking them spatially and temporally in living organcells, then increasing their numbers in a test tube and finally tracking them spatially and temporally in living organisms.

Scientists have already reported progress in growing precursor cells for eggs and sperm from both iPS and embryonic stem cell lines.