Sentences with phrase «cell precursors into»

Ultimately, this activity increases cellular regeneration, or self - renewal, turning white blood cell precursors into leukemia stem cells.

Not exact matches

But researchers reporting online April 14 in Nature Cell Biology claim they have found precursor stem cells in newborn and adult mice that could be prodded into producing new eggs.

In newborn mammals, the SVZ is the biggest depot for the precursor cells that migrate to populate various brain regions, and differentiate into multiple cell types.

The scientists then progressed these endoderm cells two more steps, first into pancreatic precursor cells, and then into fully - functional pancreatic beta cells.

If these precursor cells can be coaxed into becoming fully functioning sperm cells, the technique could allow infertile men to father their own children, and even allow women to produce their own sperm.

Tanyi and colleagues made each patient's vaccine by sifting through the patient's own peripheral blood mononuclear cells for suitable precursor cells, and then growing these, in the lab, into a large population of dendritic cells.

Using normal kidney development as a roadmap, the BWH investigators developed an efficient method to create kidney precursor cells that self assemble into structures which mimic complex structures of the kidney.

The rats were then divided into eight treatment groups of 15 animals each to test slightly differing combinations of chemicals that would allow the precursor cells to take on their desired roles.

Even though the reproductive age for humans is around 15 — 45 years old, the precursor cells that go on to produce human eggs or sperm are formed much earlier, when the fertilized egg grows into a tiny ball of cells in the mother's womb.

These immortal precursor cells could then be «grown up» in petri dishes and differentiated into normal fat cells.

When human stem cells develop into beta cells in a dish, they only reach a precursor stage, unable to fully mature; this prevents them from effectively producing insulin in response to glucose.

«Insights into the development of sperm and egg cell precursors in the embryo.»

This is all it takes for a so - called precursor fat cell to have its «epigenetic recipe» on how to correctly develop into a mature fat cell, reprogrammed.

With a cell - by - cell assessment of gene activity they are monitoring how precursor cells shape and organize themselves into something loosely resembling a functioning liver.

In theory, if the precursor cells can be pushed to mature into adulthood, they may become capable of producing myelin.

The green glowing center of this Arabidopsis root contains a protein that helps transform immature precursor cells into some of the specialized cells that make up the plant's root tip.

They used immortalized myeloid precursor cells — so - called ERHoxb8 cells — which multiply almost endlessly in a test tube and, under certain conditions, can develop into immune cells.

The team went on to show that supplementing heavy stable isotope - labeled forms of these precursors led to incorporation of heavy amino acids into proteins produced in enzyme expressing cells.

Over the past several decades, Benfey and colleagues have shown that Short - root acts as a master switch, initiating the process that transforms general purpose precursor cells into the specialized cells found in certain parts of the Arabidopsis root.

In the first, surgeons will inject ES - cell - derived neuronal - precursor cells into the brains of individuals with Parkinson's disease.

Zhou's team will coax ES cells to develop into precursors to neurons, and will then inject them into the striatum, a central region of the brain implicated in the disease.

Activating RXR triggered a cascade of changes in muscle precursor cells and white fat that ultimately converted them into brown fat - like cells.

Precursor cells can turn into other kinds of neurons, and could accumulate dangerous mutations during their many divisions, says Loring.

Each cell will split into two daughter cells, precursors to full neurons, both of which migrate out of the niche.

The experiment shows that precursor cells can develop into functional organs when placed within the body of an adult mammal, says Takebe, who hopes to use the technique to grow organs in nonhuman primates and eventually in humans.

TOKYO — A Japanese group has generated functional human livers by creating liver precursor cells in the laboratory and then transplanting them into mice to complete the developmental process.

UVA scientists were surprised to discover that the heart's inner lining forms from the same stem cells, known as «precursor cells,» that turn into blood.

Researchers at the Stanford University School of Medicine have succeeded in transforming skin cells directly into oligodendrocyte precursor cells, the cells that wrap nerve cells in the insulating myelin sheaths that help nerve signals propagate.

New research provides critical insights into how normal breast precursor cells may be genetically vulnerable to develop into cancer.

It involves injecting short segments of an insulin precursor molecule into the blood, helping to train immune cells to stop attacking the insulin - producing pancreatic cells.

Then, they implanted the neuron precursor cells into the ears of gerbils with damaged ear neurons and followed the animals for 10 weeks.

These neural precursor cells will develop into neurons when they reach the gut.

The first step of our program is to apply the previously established lab - culture conditions that first commit human ES (hES) and iPS cells into retinal precursors.

By carefully guiding the cells» choices at each fork in the road, Loh and Chen were able to generate bone cell precursors that formed human bone when transplanted into laboratory mice and beating heart muscle cells, as well as 10 other mesodermal - derived cell lineages.

They used pharmaceutical drugs to catch and maintain heart stem cells at the cardiac precursor state before they developed into fully - functional heart cells.

Interneuron cell - based therapy in AD and related models: During brain development, embryonic interneuron precursors are generated in the medial ganglionic eminence (MGE) and retain a remarkable capacity for migration and integration in adult host brains, where they fully mature into functional inhibitory interneurons.

There are some data that suggest the pathogens themselves can produce amyloid precursor protein (APP), which is processed into amyloid - β by the cell (2).

In his laboratory mice, Dr. Ding has now used chemical reprogramming to turn fibroblasts into neural «precursor» cells with the potential to become new oligodendrocytes.

We next examined the question of whether the precursor cells from which hGDAsBMP were derived were also capable of promoting behavioral recovery after DLF transection and found that pre-differentiation of these precursor cells into astrocytes was essential to promote significant functional recovery.

Izpisua Belmonte and colleagues published work in the journal Nature last year reporting that they had been able to integrate human stem cells into early - stage mouse embryos so that the human stem cells began the first stages of differentiation — they appeared to begin the process of generating precursors of the body's various tissues and organs.

We show that subpopulations of human astrocytes, generated by activation of different signaling pathways in the same population of human glial precursor cells, have markedly different effects when transplanted into the injured spinal cord.

One of the striking differences in outcome between our studies and work on oligodendrocyte and oligodendrocyte - precursor replacement lies in the finding that differentiation of precursor cells into a specific astrocyte subtype prior to transplantation provides a much greater level of benefit than transplantation of the precursor cells themselves.

These results provide a defined population of human astrocytes suitable for further pre-clinical development for treatment of SCI, and demonstrate that pre-differentiation into astrocytes prior to transplantation provides a much greater functional recovery than transplantation of precursor cells themselves.

In order to trace and measure viral genomes, O'Hare's team use DNA precursors to feed into cells.

The underlying mechanisms accounting for why hGDAsBMP are so much more beneficial in terms of neuroprotection and functional recovery than either hGDAsCNTF or undifferentiated precursor cells when transplanted into spinal cord injured rats remain to be investigated, but it is likely that multiple cellular functions are involved.

While our data do not provide insight into the dynamics of the entire Nanog low population, it suggests that a sub-fraction of low Nanog cells represents PrEn precursors, in addition to the already characterized PrEc precursor population.

Moreover, in PrEn precursors, the Nanog low population can itself be split based on the expression of Oct4 or SSEA - 1 into a state expressing reasonably high level of PrEn genes (V+S −), and a less differentiated cell type exhibiting a PrEn bias, but with similar regenerative capacities to the Nanog high population (V+S +).

Second, the aging thymus gland, where precursor stem cells are transformed into effective T - cells, slowly shrinks with age, losing the cells that are responsible for educating emerging immunological warriors.

Now, ViaCyte is testing the VC - 01 ™ product candidate made up of macro-encapsulated pancreatic progenitor cells, precursor cells that are expected to differentiate into mature cells that produce insulin and other hormones.

The work, published in Cell Stem Cell on September 14, 2017, offers insight into why an imbalance between these precursor cells and neurons might contribute to mental illness or age - related brain disease.