Sentences with phrase «cell progenitors derived»

Writing in Journal of Immunology, lead author and BSI member, Professor Graham Anderson explains, «Post-transplantation, T - cell progenitors derived from the bone marrow transplant can struggle to enter the thymus, as if the doorway to the thymus is closed.

The Company's technology is based on pancreatic beta cell progenitors derived from human pluripotent stem cells.

Not exact matches

The neural progenitor cells used were derived from iPSCs (induced pluripotent stem cells), which were in turn derived from donor skin cells.

Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to replace or regenerate cells destroyed by a variety of diseases.

In a series of experiments reported in PLOS ONE in August, the Tufts researchers showed that exosomes from PC12 cells (neuron - like progenitor cells derived from rats) at various stages of their own differentiation could, in turn, cause hMSCs to become neuron - like cells.

As a consequence, neural progenitor cells derived from these kids proliferate faster than controls, explaining the big brain phenotype.»

This image shows induced pluripotent stem cell - derived neural progenitor cells after neuronal differentiation.

Geron Corp., which earlier got permission to administer stem cell — derived oligodendrocyte progenitors to treat spinal injury, has been bogged down in delays and may not begin its trial until late next year.

Next steps include pursuing therapies, including antibodies and herb - derived treatments, that target the misguided progenitor cells, instead of only targeting the cancerous breast tissue they produce, Ko said.

For that, they quantified how 85 nanoparticles delivered DNA barcodes to eight cell populations in the spleen, and found that cell types derived from myeloid progenitors tended to be targeted by similar nanoparticles.

In addition, we were able to differentiate these cells into neurons — and that's a characteristic of all neural crest - derived tissue and its progenitors»

Researchers from Massachusetts Eye and Ear have, for the first time, identified rapidly proliferating cells (known as «neural crest - derived progenitor cells») in the corneal endothelium of specimens from normal corneas and from corneas with Fuchs» Endothelial Corneal Dystrophy (FECD), a condition in which the cells responsible for keeping the cornea clear die prematurely — often leading to blindness.

Most of these trials involve stem cell - derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

This is a reconstitution of glomeruli by propagated nephron progenitors derived from human iPS cells.

Further testing of this culture method on kidney progenitor cells derived from human iPS cells resulted in four times the total amount of cells over 8 days.

Ten people will receive injections into the injury site of hESC - derived oligodendrocyte progenitor cells, which stimulate the growth of new and severed nerves and recoat damaged nerves with myelin.

In contrast, the growth of clones derived from progenitor cells becomes checked by increasing levels of apoptosis, leading to the formation of benign lesions.

Most of these trials involve stem cell — derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

Many clinical trials have used bone marrow - derived cells, and the benefits here appear to come mostly from the â $ œparacrine» nurse function. A more ambitious approach is to use progenitor - type cells, which may have to come from iPS cells or cardiac stem cells isolated via biopsy - like procedures.

Human bone marrow (BM)- derived progenitor and stem cells administered with an appropriate scaffold represents a potentially exciting alternative treatment option [2], but only if we can discover a safe and rapid strategy to enhance the relatively low inherent osteogenic potential of BM.

AMSBIO has introduced a new range of neural progenitor cells, and cerebral cortical neurons, derived from human induced pluripotent stem (iPS) cells.

New research in SCTM describes a safe and effective new strategy for the treatment of type 1 diabetes using induced pluripotent stem cell - derived progenitors

NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals models.

Maturation of human embryonic stem cell - derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice.

For quality control, researchers want to figure out how to ensure that the stem - cell - derived cardiac muscle or neural progenitor or pancreas cells (or whatever) are as pure as possible.

Ethanol - mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells - derived neural progenitor cells.

The chemokine receptor CXCR - 4 is expressed on CD34 + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell - derived factor - 1.

Transcription Factor - Induced Lineage Selection of Stem Cell - Derived Neural Progenitor Cells

Mesenchymal stem cells (MSCs) got their name because they're thought to primarily contain progenitors in the mesenchyme, which is a collection of cells mostly derived from mesoderm.

Ovine bone - and marrow - derived progenitor cells and their potential for scaffold - based bone tissue engineering applications in vitro and in vivo.

At the International Society for Stem Cell Research 2017 Annual Meeting (June 14 - 17, 2017; Boston, USA), Asterias Biotherapeutics, Inc (CA, USA) will present new 9 - month efficacy and safety data from their ongoing SCiStar Phase I / IIa trial of human embryonic stem cell - derived oligodendrocyte progenitor ceCell Research 2017 Annual Meeting (June 14 - 17, 2017; Boston, USA), Asterias Biotherapeutics, Inc (CA, USA) will present new 9 - month efficacy and safety data from their ongoing SCiStar Phase I / IIa trial of human embryonic stem cell - derived oligodendrocyte progenitor cecell - derived oligodendrocyte progenitor cells.

Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.

Review of «Antitumor Effects of CD40 Ligand - Expressing Endothelial Progenitor Cells Derived From Human Induced Pluripotent Stem Cells in a Metastatic Breast Cancer Model» from Stem Cells TM by Stuart P. Atkinson.

Endothelial progenitor cells derived from induced pluripotent stem cells which target tumors can be modified to carry an anti-tumorigenic «payload» and promoter tumor growth inhibitionsy

Preclinical Safety of Human Embryonic Stem Cell - Derived Oligodendrocyte Progenitors Supporting Clinical Trials In Spinal Cord Injury.

Cytokine expression by human marrow - derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL - 1 alpha.

Immunological properties of human embryonic stem cell - derived oligodendrocyte progenitor cells.

We find that crustacean limb regeneration relies lineage - committed progenitor cells: muscles derive from satellite - like stem cells, whereas epidermis regenerates from existing epidermal cells.

To carry out pre-clinical testing of stem cell - derived mesDA and striatal GABAergic progenitors in rodent models of PD and HD with the goal to generate efficient and safe candidate cells for clinical use;

Human Embryonic Stem Cell - Derived Oligodendrocyte Progenitor Cell Transplants Improve Recovery After Cervical Spinal Cord Injury.

Osteogenic induction of human bone marrow - derived mesenchymal progenitor cells in novel synthetic polymer - hydrogel matrices.

The researchers conclude that this could be owing to the bone marrow - derived MSCs being able to act as progenitor cells, similar to alveolar epithelial type II cells.

The FDA has approved the use of stem cell - based products, including cord blood - derived hematopoietic progenitor cells (blood forming stem cells) for many diseases.

To highlight the potentially important role of 3D culture conditions, the authors compared 2D monolayers of hepatocyte progenitors, fetal liver stromal cells, or adult bone marrow - derived stromal progenitor cells to their 3D counterparts cultured on liver extracellular matrix (3D - ECM) constructs.

Our therapy is based on pancreatic beta cell progenitors (Pro-Islet (TM)-RRB- derived from human pluripotent stem cells.

AST - OPC1, an oligodendrocyte progenitor cell population derived from human embryonic stem cells, has been shown in preclinical testing in animals and in vitro to have three potentially reparative functions that address the complex pathologies observed in demyelination disorders, such as spinal cord injuries, and multiple neurodegenerative diseases, including multiple sclerosis and white matter stroke.

The Company's lead product is based on the production of pancreatic progenitors derived from human pluripotent stem cells.

It has also been shown that fibroblasts [43], [60] and placenta - derived progenitor cells [43] are unable to maintain visual functions long - term, further indicating that the rescue effects seen in the RCS rat model are not the result of a non-specific event.

In the CNS, transplanted human neural progenitor cells derived from prenatal cortex (hNPCctx) display characteristics important for cell - based rescue of degenerating neurons.

The PEC - Direct product candidate delivers stem cell - derived PEC - 01 pancreatic progenitor cells in a device designed to allow direct vascularization of the cells, and is being developed for type 1 diabetes patients that have severe hypoglycemic episodes, extreme glycemic lability, and / or impaired awareness of hypoglycemia.