Sentences with phrase «cell progenitors in»

Not exact matches

It's blood in a newborn baby's umbilical cord that's rich in a type of stem cell called hematopoietic progenitor cells (HPCs).

Transient Silencing of 14 -3-3sigma promotes proliferation of p63 - positive progenitor cells isolated from human breastmilk in mammary epithelial cell culture.

«We've shown that SIF - seq can be used to identify enhancers active in cardiomyocytes, neural progenitor cells, and embryonic stem cells, and we think that it has the potential to be expanded for use in a much wider variety of cell types,» Dickel says.

«What's really exciting about this was that the activity differences were detected at a critical time in brain development: when neural progenitor cells are proliferating and expanding in number, just prior to producing neurons,» Silver said.

The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

The findings, from the Emory / Johns Hopkins / Florida State team that showed this spring that neural progenitor cells are particularly vulnerable to Zika infection, were published in Nucleic Acid Research.

The neural progenitor cells used were derived from iPSCs (induced pluripotent stem cells), which were in turn derived from donor skin cells.

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

«Suppressing a progenitor from creating the subtype of dendritic cells implicated in causing lupus, for example, could be an efficient way of treating autoimmune diseases while minimising the impact on the rest of the immune system.

Both Zika strains were able to infect and cause cell death in neural progenitor cells.

We were able to show that progenitor cells in our model and in patients with essential thrombocythemia, had a signature of excessive thrombopoietin stimulation.

By using genetic «signatures», we were able to compare the blood progenitor cells responsible for overproducing megakaryocytes in our model, to progenitor cells in people with essential thrombocythemia.

This type of stem cell, called an oligodendrocyte progenitor cell, is found in the brain and spinal cord.

But it was another three decades before Klassen — who has used retinal progenitor cells to restore vision in mice, cats, dogs and pigs — could conduct human trials involving retinitis pigmentosa.

In June 2015, she became the first patient in North America to receive an eye injection of about half a million retinal progenitor cellIn June 2015, she became the first patient in North America to receive an eye injection of about half a million retinal progenitor cellin North America to receive an eye injection of about half a million retinal progenitor cells.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

An example of epigenetic modifications leading to cancer progenitor cell formation possibly occurs in leukemia development.

«Esophageal cancer «cell of origin» identified: In mice, basal progenitor cells give rise to Barrett's esophagus, a precursor to cancer.»

The same observations were made in organoids (artificially grown masses of cells that resemble an organ) created from unique basal progenitor cells that were isolated from the gastroesophageal junction in mice and humans.

«All of the known cells in this tissue remained the same, but we found a previously unidentified zone populated by unique basal progenitor cells,» he said.

These progenitor cells are often drug resistant and can initiate cancer development and are possibly involved in cancer relapse.

Studies in cancer patients indicate reduced rates of relapse when patients are pretreated with epigenetic drugs due to its far - reaching capabilities; killing progenitor cells at the site of the tumor, in circulation, or at a distant site.

In humans, basal progenitors can undergo multiple rounds of cell division, thereby substantially increasing neuron number and ultimately the size of the neocortex.

Strikingly, sustaining Pax6 expression in mouse basal progenitors increased their capacity to undergo multiple rounds of cell division, as typically observed in primates.

«The discovery of the novel progenitor represents a fundamental advance in this field and potentially to the liver regeneration field using cell therapy,» said the study's senior author, Valerie Gouon - Evans, PharmD, PhD, Assistant Professor, in the Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, at the Icahn School of Medicine at Mount Sicell therapy,» said the study's senior author, Valerie Gouon - Evans, PharmD, PhD, Assistant Professor, in the Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, at the Icahn School of Medicine at Mount SiCell Institute, at the Icahn School of Medicine at Mount Sinai.

«If you see consistent phenotypes in different models, the things that are happening are probably important,» says Guo - li Ming of Johns Hopkins University School of Medicine in Baltimore, Maryland, who led the earlier studies of Zika in human neural progenitor cells.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

LPA receptors are all over neural progenitor cells, which go on to form neurons and other types of cells in a young brain.

The LPA receptor is expressed in the brain of human fetuses, just as in mice, and in the same types of neural progenitor cells.

The new method, described in the journal Stem Cells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem cCells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem ccells and muscle progenitors directly from human pluripotent stem cellscells.

Additionally, work in a mouse model revealed similar cells, indicating that the progenitors are conserved from mouse to human, and therefore, they must be «important cells with promising potential for cell therapy in treating liver disease,» explained Dr. Gouon - Evans.

In conjunction with the laboratory of Matthew J. Evans, PhD, from the Department of Microbiology at Icahn School of Medicine at Mount Sinai, investigators demonstrated the functionality of the liver cells generated from the progenitors, as the liver cells can be infected by the hepatitis C virus, a property restricted to liver cells exclusively.

In the bone marrow, blood stem cells give rise to a large variety of mature blood cells via progenitor cells at various stages of maturation.

Some days, she spends mornings in surgery or the clinic and afternoons in the lab trying to use progenitor cells to improve wound healing.

When Busch turned on the marker in adult animals, it became visible that at least one third (approximately 5000 cells) of a mouse's hematopoietic stem cells produce differentiated progenitor cells.

Adapting a method previously used to make brain cells, Masatoshi Suzuki, an assistant professor of comparative biosciences in the School of Veterinary Medicine, has directed those universal stem cells to become both adult muscle cells and muscle progenitors.

In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cellIn a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cellin the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cellin mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cellin the developing human brain, in mouse cortical progenitor cellin mouse cortical progenitor cells.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

The researchers then used a 3 - D cell culture system to coax their mutant and healthy hPSCs down the differentiation pathway into becoming kidney progenitor cells and finally the proximal tubule cells found in kidney nephrons.

«Starting with pluripotent stem cells that are not muscle cells, but can become all existing cells in our body, allows us to grow an unlimited number of myogenic progenitor cells,» said Nenad Bursac, professor of biomedical engineering at Duke University.

«We knew that ANG was involved in promoting cell growth so it was not unexpected to find that ANG stimulates proliferation of myeloid progenitor cells,» said Guo - fu Hu, PhD, Investigator in the Molecular Oncology Research Institute at Tufts Medical Center, and the paper's senior author.

They grew human hippocampal progenitor cells in a dish and added sertraline.

In the paper, the researchers show for the first time that ANG simultaneously reduces proliferation of stem cells and promotes proliferation of myeloid progenitor cells that give rise to mature myeloid cells.

In fact, only 4 percent of stem cell transfers produced nascent embryos compared with 8 percent of progenitor cells and 35 percent of granulocytes.

In a series of experiments reported in PLOS ONE in August, the Tufts researchers showed that exosomes from PC12 cells (neuron - like progenitor cells derived from rats) at various stages of their own differentiation could, in turn, cause hMSCs to become neuron - like cellIn a series of experiments reported in PLOS ONE in August, the Tufts researchers showed that exosomes from PC12 cells (neuron - like progenitor cells derived from rats) at various stages of their own differentiation could, in turn, cause hMSCs to become neuron - like cellin PLOS ONE in August, the Tufts researchers showed that exosomes from PC12 cells (neuron - like progenitor cells derived from rats) at various stages of their own differentiation could, in turn, cause hMSCs to become neuron - like cellin August, the Tufts researchers showed that exosomes from PC12 cells (neuron - like progenitor cells derived from rats) at various stages of their own differentiation could, in turn, cause hMSCs to become neuron - like cellin turn, cause hMSCs to become neuron - like cells.

The findings were published in an article, «Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells,» in the August 11, 2016 issue of the journal Cell.

They may arise from either embryonic progenitors or bone marrow cells in adults.

Moreover, a substantial increase in circulating endothelial progenitor cells, which repair damaged blood vessels, was noted after consuming bread made from the ancient grain Verna.

«While these tumors appear to be muscle cells under the microscope, and clinicians had thought that they arose from muscle progenitor cells, that didn't explain why the tumors can occur in tissues that don't have skeletal muscle, like bladder, prostate and liver,» he continued.