Sentences with phrase «cell receptor molecule»

The fact the sperm cell receptor molecules are found alongside desensitisation proteins — just as they are in the nose — strongly suggests that they detect odours, says Snyder.

Not exact matches

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

The protein expressed by the gene is thought to bind to serotonin receptor molecules and ferry them to the cell surface, positioning them to receive serotonin's signals from neighboring cells.

Receptors are «molecular switches» — when a specific molecule binds to them, they change shape and send a signal to the cell to perform a certain function.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

The key actors here likely are mu - opioid receptors, molecules on cell membranes that allow opioids to bind to them and interact with the cell itself, he says.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

The investigators also discovered that neutrophils secrete a molecule called S100A8 / S100A9 that interacts with a receptor named RAGE (the Receptor for Advanced Glycation Endproducts) on bone marroreceptor named RAGE (the Receptor for Advanced Glycation Endproducts) on bone marroReceptor for Advanced Glycation Endproducts) on bone marrow cells.

The unaltered hemagglutinin is akin to a key that unlocks a so - called receptor molecule in cells lining the upper airways of humans and other mammals.

Major histocompatibility complex class II (MHC II) molecules capture peptides within the endocytic pathway to generate T cell receptor (TCR) ligands.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

Lanza also designed the nanoparticles to carry targeting molecules that home in on and bind to cancer cells that carry the complementary receptor, like a lock and key.

Different drug molecules make it possible to affect the function of these receptors and, consequently, to prevent cell activation and mediator release.

The receptor then triggers the release inside the cell of a second signal: a molecule called cyclic AMP (cAMP).

Endocannabinoids act on a group of cell - surface molecules called cannabinoid receptors that help to regulate appetite, mood and memory.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

When G - CSF activates its receptor, it ultimately activates proteins called STATs; the team engineered the cells to churn out the light - generating protein luciferase, which would be turned on by the STAT molecules.

When THC strikes specific cannabinoid receptors, it triggers domino chains of interacting molecules in neurons that culminate in both unusually elevated and abnormally low levels of various neurotransmitters (the molecules that brain cells use to communicate with one another).

Zwiebel and colleagues scanned the mosquito genome looking for genes similar to those that generate fruit fly odorant receptors, proteins that project from nerve cells and initiate a biochemical cascade when they encounter certain molecules in the air.

Studying these receptor molecules in detail is extremely difficult, because they almost always stop working if removed from the cell membrane.

«Plasmodium falciparum malaria parasites have evolved several key - like molecules to enter into human red blood cells through different door - like host receptors.

Current thinking regarding type III hypersensitivity is that immune cells within tissues sense the presence of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that activate the endothelial cells lining adjacent blood vessels to promote the recruitment of neutrophils.

The engineered protein has two ends: one activates T cells by binding to a surface molecule called the CD3 receptor, and the other — based on an antibody called VRC07 — powerfully binds to more than 90 percent of HIV strains.

The odorant receptor molecules sit on the surface of sensory nerve cells in our nose.

Palovarotene is a retinoic acid receptor (RAR) agonist, a molecule that binds a cell membrane receptor to trigger molecular events that regulate cell function.

It is comprised of lipid signaling molecules called endocannabinoids — which can be thought of as the body's own «natural cannabis» — that bind to cannabinoid receptors located on cells throughout the body.

Liu and her team found that without gp96 - a molecule inside most cells that helps Toll - like receptors and integrins fold and function properly - pAPCs in the gut were more inflammatory.

The ability to track markers inside and outside a cell simultaneously, and to map them atop images showing the cell's shape, is also helping researchers study the metabolic effects of signaling molecules, such as G - protein - coupled receptors.

The research provides the first link between oxytocin — dubbed the «love hormone» — and anandamide, which has been called the «bliss molecule» for its role in activating cannabinoid receptors in brain cells to heighten motivation and happiness.

Known as the phosphatidylserine receptor, or PSR - 1, the molecule can locate and clear out apoptotic cells that are pre-programmed to die as well as necrotic cells that have been injured and are causing inflammation, said CU - Boulder Professor Ding Xue, who led one study and co-authored the other.

In experiments in mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two weeks.

The MSRs were then coated with lipids that formed a thin supported lipid bilayer (SLB), which resembles the outer membrane of APCs and that the researchers then functionalized with a pair of T cell - stimulating antibodies that remain mobile in the lipid layer and can bind to receptor / co-receptor molecules on the surface of T cells.

«The NILR1 is the genetic code for a receptor protein that is localized to the surface of plant cells and is able to bind and recognize other molecules,» says Prof. Florian Grundler, chair at the Department of Molecular Phytomedicine at the University of Bonn.

When a THC molecule binds to one of these CB1 receptors, it changes form, triggering a cascade of various signals inside the cell.

If the antigen receptor binds a body molecule too tightly, the developing T cell might eventually cause an autoimmune disease; in this case negative selection is triggered, and the cell dies.

In particular, Nguyen and Ehrenstein discovered that adalimumab increases the expression of TNF on the surface of patient monocytes and promotes the association of these TNF molecules with receptor proteins on the surface of regulatory T cells.

During their maturation process, T cells in the thymus undergo various tests requiring T cell's antigen receptor to bind the body's own molecules.

A normal cell has chemical receptors on its surface that link up with specific molecules generated by the body and control the timing of such functions as eating and sleeping.

Dogs can do that because their noses contain 900 different types of olfactory receptors, chemical detectors in cells that respond to many different kinds of odor molecules in particular ways.

The study shows that activating the bile acid receptor TGR5 with molecules that mimic the action of bile acids (so called «mimetics») induces a remodeling of white fat cells into beige fat cells.

So to garner enough iron to survive, bacteria secrete small molecules called siderophores to seek out iron in the environment and bring it back into the cell through siderophore - specific receptors.

To address such obstacles, Roybal, now an assistant professor at the University of California, San Francisco and his colleague Leonardo Morsut turned to a signaling molecule on T cells called the Notch receptor, known to be involved in several developmental and biological processes.

In collaboration with researchers at the Lead Discovery Centre of the Max Planck Society in Germany, they developed an inhibitor molecule directed against the receptors that are regulated by Cbl - b in NK cells, the so called TAM - receptors.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

Receptors are protein structures that molecules bind with to induce cells to respond.

These designer proteins bind tightly to CGRP molecules or their receptors on trigeminal nerve cells, preventing cell activation.

His and Ferkey's new study found that PRMT - 5 helps a methyl molecule attach to dopamine receptors called D2 - like receptors in nerve cells.

The group has already identified several candidate molecules which activate GDNF receptors in immortalized cells and shown that one of them promoted survival of dopamineric neurons in vitro.

«Tfh cells control the whole process of generating high affinity antibodies, and ICOS is a receptor molecule strongly required for Tfh cells to work.

The scientists also found that endothelial cells themselves give the signal for their own death: To do this, the vascular wall cells have a receptor molecule called Death Receptor 6 (DR6) on their receptor molecule called Death Receptor 6 (DR6) on their Receptor 6 (DR6) on their surface.