Sentences with phrase «cell receptor sequencing»

Robins received the honor along with his brother Chad Robins, co-founder and chief executive officer of Adaptive, a Seattle - based spinoff of Fred Hutch that offers high - throughput T - and B - cell receptor sequencing to customers in academia and industry.

Using an unsupervised learning algorithm, the team was able to convert the T - cell receptor sequencing data into numeric distances based on similarities in the receptor sequences and cluster them by functional specificity.

Not exact matches

«We were looking at the amino acid sequences of T cell receptors when Tomer asked what the corresponding epitope was for a particular receptor,» Thomas said.

The tools included TCRdist, which researchers used to calculate the similarity and differences of key features of T cell receptors, such as amino acid sequences in important regions for antigen recognition.

Roswell Park Cancer Institute (RPCI) researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

Here, Patil et al. have carried out single RNA - seq and sequenced the T cell receptors (TCRs) of CD4 + T cells from human blood to identify precursors that give rise to CD4 - CTLs.

The team used a statistical model of T cell receptor formation to analyze receptor DNA sequences in blood samples from adult pairs of identical twins.

These cells also shared stretches of genetic sequence that code for the same antigen receptors.

To do this, they incorporated the gene sequence of each receptor into cultured cells and then probed the cells to determine if they were activated by one or more of 25 different bitter - tasting chemicals.

Now, Skehel, along with colleagues at Harvard, Yale, and Emory University in Atlanta, Georgia, has used that sequence to build the virus's hemagglutinin (HA)-- a protein that latches onto receptors on the host cell surface — and determine its structure.

«T - cell receptors that are very similar, with slight differences in their sequences, may be recognizing the same antigen.»

The Johns Hopkins team tested ImmunoMap's ability to correlate immune responses on receptor sequencing data from T - cells in the tumors of 34 patients with cancer enrolled in a nationwide clinical trial of the immunotherapy drug nivolumab.

Roswell Park Comprehensive Cancer Center researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

Then they compiled and compared the detailed sequence — the order of the chemical building blocks — of the peptides that bound to each T - cell receptor.

Toll - like receptor 9 signaling activates NF - κB through IFN regulatory factor - 8 / IFN consensus sequence binding protein in dendritic cells.

In this context, the Lingwood laboratory studies B cell antibody responses to both HIV and influenza with the goal of 1) understanding how antigenic sites of vulnerability are initially perceived by specific germline B cell receptor (BCR) sequences and 2) how that recognition process can direct antibody affinity maturation toward production of broadly neutralizing anti-viral responses.

Infant T cell repertoire analysis combines quantitative PCR to determine relative frequency of T cell receptor chain families with deep sequencing (LINK TO URI GSC) of the CDR3 region to evaluate clonal diversity within each family.

Join her to learn how immunoSEQ ® Assay combines bias - controlled multiplex PCR with high - throughput sequencing and expert bioinformatics to deliver accurate, quantitative sequencing results for millions of T and B cell receptors.

Association of phosphatidylinositol 3 - kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.

To identify and track clonal T cell receptor (TRB) gene rearrangements using next - generation sequencing with the Illumina MiSeq ®

SAN DIEGO, March 28, 2017 (GLOBE NEWSWIRE)-- Invivoscribe ® Technologies Inc., a global company with decades of experience providing internationally standardized clonality and biomarker testing solutions for the fields of oncology, personalized molecular diagnostics ®, and personalized molecular medicine ®, reports that its next - generation sequencing (NGS) LymphoTrack ® Assay kits are being used by its LabPMM ® clinical laboratories, pharmaceutical partners, and cancer centers to identify and monitor chimeric antigen receptor T - cells (CAR - T) and engineered T - cell receptors in peripheral blood of subjects in support of immuno - therapeutic drug development and treatment regimen development for both hematologic and solid tumors.

We sequenced T - cell receptor Vβ genes in expanded microbe - reactive T - cell lines to determine their clonal diversity.

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