Sentences with phrase «cell receptors for»

Dogs with myasthenia gravis either don't have the normal number of skeletal muscle cell receptors for the neurotransmitter acetylcholine when they are born (congenital myasthenia gravis), or the receptors that they do have are defective or have been damaged at some point after their birth (acquired myasthenia gravis).

T4 can be converted to triiodothyronine (T3), the active hormone that has a metabolic effect on the body, or it can be converted to reverse T3, an inactive form of T3 that actually blocks the cell receptors for thyroid hormones, thus blocking the effect of T3.

A type of sphingosine 1 - phosphate, and cell receptors for it, also were observed in the cells in the regenerating muscle fibers.

Without cell receptors for sphingosine 1 - phosphate, an embryo would fail to develop.

Grouping T cell receptors for a given epitope revealed underlying common features that characterized the bulk of the repertoire,» said first author Pradyot Dash, D.V.M., Ph.D., a staff scientist in Thomas» laboratory.

For the CRISPR trial, a UPenn - led team wants to remove T cells from patients and use a harmless virus to give the cells a receptor for NY - ESO - 1, a protein that is often present on certain tumors but not on most healthy cells.

It does so by hooking onto a protein called LAMP1 — a previously undiscovered interior cell receptor for the virus.

The affinity of B cell receptor for antigen and the expression level of Bach2 are inversely correlated in germinal center B cells.

Not exact matches

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

Hormone binds to cells that have receptors for it.

At this time, trials and plans for its other CD19 - directed chimeric antigen receptor (CAR) T - cell product candidates, including JCAR017, are not affected.

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

All an evolutionary storyteller has to do is to start with the apparently simplest version, ignore the neural equipment that has to be present for an organism to make any use of a «photon receptor,» and spin a charming tale about how a tiny primitive light - sensing cell might grow up to be a full - fledged eye.

Specifically, when capsaicin frequently binds to receptors within the human central nervous system's TRPV1 channel (the sensory receptor system for pain and heat detection), these receptors deplete and this depletion results in a whole host of benefits for the central nervous system at large, including terminating cancer cells, increasing the metabolic rate and digestive efficiency, increasing circulatory blood flow, and combatting inflammation, and making you feel better about the world.

These protein and fat sources are extraordinarily critical for rebuilding healthy cell membranes with normalized insulin receptor activity.

Every cell in the body have vitamin D receptors, which means that D - vitamin is very important for optimal health and the immune system.

These cells are sparse up until 38 weeks, increasing gradually after that time, and increasing 300-fold after labor has begun.7 The relative scarcity of oxytocin receptor sites is one of the main lines of defense for keeping the uterus quiescent throughout the entire preterm period — but it is not the only one.

Since dendritic cells have a receptor for CCL21, they manage to sense the direction — by «smelling» the higher concentration of the mediator.

«Once this novel tumor - homing agent binds to the EphA2 receptor, the oncogene functions as a cancer - specific molecular Trojan horse for paclitaxel, carrying the drug inside the cancel cell, killing the cell, and thwarting metastasis,» said Maurizio Pellecchia, a professor of biomedical sciences at UCR's School of Medicine who led the research.

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

For some years now, a new class of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor cell receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer cells with the antibody and triggers their deaFor some years now, a new class of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor cell receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer cells with the antibody and triggers their deafor a chemical substance that enters the cancer cells with the antibody and triggers their death.

«We were looking at the amino acid sequences of T cell receptors when Tomer asked what the corresponding epitope was for a particular receptor,» Thomas said.

The tools included TCRdist, which researchers used to calculate the similarity and differences of key features of T cell receptors, such as amino acid sequences in important regions for antigen recognition.

These are receptors on immune cells, which control for example effector T - cells by dampening their activation if damage to healthy cells is imminent.

The investigators also discovered that neutrophils secrete a molecule called S100A8 / S100A9 that interacts with a receptor named RAGE (the Receptor for Advanced Glycation Endproducts) on bone marroreceptor named RAGE (the Receptor for Advanced Glycation Endproducts) on bone marroReceptor for Advanced Glycation Endproducts) on bone marrow cells.

Since genes for the T - cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig - like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B - cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains.

«Fibroblast growth factor receptor inhibitors are new therapies being developed in clinical trials for patients whose cancer cells have genetic alterations in this family of genes,» says Roychowdhury, a member of the OSUCCC — James Translational Therapeutics Program.

The activating receptor NKp46 is important for keeping the responses of natural killer cells in check.

We designed chimeric antigen receptor (CAR) T cells that specifically target podoplanin (PDPN), a key protein for the progression of solid tumors, including GBM.»

Called TSH for short, this hormone attaches to a receptor on the thyroid cell surface, triggering a series of signals that provoke the gland to pump out thyroid hormones.

Not only did the cells churn out CRH, they also harbored cell surface receptors for the hormone.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

He determined that epithelial cells lining the brain's blood vessel walls contain a surface protein, or receptor, that can snag insulin, the hormone essential for metabolizing carbohydrates and fats.

The current paper shows that treating with retinoids simultaneously with anti-estrogen therapies may pull cofactors for progesterone receptors away from their posts, disallowing their ability to open DNA at the point of CK5 and keeping the growth of dangerous CK5 + cells in check.

Besides docking to white blood cell receptors called CD4, the scientists found that HIV also enters cells via receptors — such as CCR5 — normally reserved for immune messengers called chemokines.

Work is now continuing to study what transmitter substance and what receptor on the surface of the cell are responsible for the newly discovered timing mechanism.

By studying the receptor for thrombopoietin, called Mpl, on blood cells in the bone marrow, the team pinpointed the cells involved in making platelets after thrombopoietin stimulation, and made an unexpected discovery.

A potential adrenalinelike drug for weight control must target only the fat - cell receptors to avoid dangerous side effects in the cardiovascular system.

It is thus impossible for every receptor cell to send a separate message to the brain, and the concept that the array of receptor cells is equivalent to the grain of a photographic emulsion must be abandoned.»

Without the right receptor, the virus can not attach tightly enough to invade the cell and co-opt it for replication.

The accuracy for human eye and hair color is much higher at 0.9, and chronological age — based on T cell receptors — is the same.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

Patricia McGowan of University College Dublin, Ireland, treated triple - negative cells taken from seven patients with a compound that inhibits receptors important for the cell division and spread of this form of cancer.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

The mutation, in a gene called HTR2B, prevents production of the serotonin 2B receptor, a key docking point in brain cells for the neurotransmitter serotonin.

«Cell - surface receptor offers promising breakthrough for pancreatic cancer patients.»

Although SB 247464 doesn't work with human cells, the discovery will spur the pharmaceutical industry's search for protein - mimicking drugs, says Mark Goldsmith, who studies cytokine receptors at the University of California, San Francisco.

Although the men with the mutant genes produced FSH, support cells for the sperm - producing cells in their testes lacked the receptors for the hormone.

The most common, found in nearly two - thirds of the samples, were abnormalities in genes responsible for the androgen receptor — a cell structure that sends growth signals in response to the male hormone androgen.

Zwiebel and colleagues scanned the mosquito genome looking for genes similar to those that generate fruit fly odorant receptors, proteins that project from nerve cells and initiate a biochemical cascade when they encounter certain molecules in the air.